Twyman Research Management
Specialist consultants in
scientific project development,
management and presentation
to Twyman Research Management
Twyman Research Management Ltd is a UK company that specializes in scientific project development, management and presentation, including the preparation of research proposals, project management and reporting, project dissemination and complementary activities, and expert assistance with the preparation, editing and revision of scientific manuscripts.
We have been working for more than 20 years to develop and manage research projects and improve the quality of scientific publications.
Article of the Month
Plants flower in response to various environmental cues including the day length, a phenomenon known as photoperiodism. Some plants flower only when days are short, others only when days are long, and others like tobacco (Nicotiana tabacum) can flower regardless of the day length (day neutral). This is controlled by FLOWERING LOCUS T (FT) proteins, some acting as activators and some as repressors. In December's article of the month, Schmidt et al. analyze the role of the NtFT5 gene and report that it is an indispensable major floral activator during long days. They show that tobacco plants with only one functional copy of this gene remain in the vegetative growth phase for longer, producing about 10% more biomass before flowering and also producing more seeds. NtFT5 could therefore be used as a means to increase the yields of other crop species.
Article details: Schmidt FJ et al. (2019) The major floral promoter NtFT5 in tobacco (Nicotiana tabacum) is a promising target for crop improvement. Front Plant Sci 474877.
Image shows flowering tobacco plants.
Image credit: H Zell (CC BY-SA 3.0).
Helicobacter pylori is a common bacterial pathogen in humans, causing chronic gastritis, ulcers and even stomach cancer. It is difficult to eradicate, and treatment usually involves multiple antibiotics, which can encourage the spread of antibiotic-resistant strains. In November's article of the month, Menchicchi et al. show that colloidal nanoparticles with an oily emulsion core and a coating of low-molecular-weight dextran sulfate can inhibit the adhesion of H. pylori to stomach cells, without signs of toxicity against gastrointestinal cell lines. These nanoparticles could therefore be developed as a complementary therapy against H. pylori, helping to reduce antibiotic use and prevent the emergence of multidrug-resistant bacteria.
Article details: Menchicchi B et al. (2019) Low-molecular-weight dextran sulfate nanocapsules inhibit the adhesion of Helicobacter pylori to gastric cells. ACS Appl Bio Mater 2 (11) 4777–4789.
Image shows the bacterium Helicobacter pylori.
Image credit: AJC1 (CC BY-SA 2.0).
Plant viruses are harmless to humans but have many favorable properties allowing them to be developed as imaging reagents, drug carriers and vaccines. In October's article of the month, Wang et al. show that the immunostimulatory properties of Cowpea mosaic virus in a mouse model of ovarian cancer differ according to whether they are presented as complete virus particles (including genomic RNA) or as empty protein shells. The two different forms trigger overlapping immune responses, with both types of particles promoting the secretion of cytokines and the stimulation of immune cells, but only the RNA-containing particles recruiting tumor-infiltrating neutrophils and other antigen-presenting cells to the tumor site. The detailed investigation of immune responses to different plant virus formulations will allow the development of tailored vaccines and adjuvants for cancer therapy.
Article details: Wang C et al. (2019) Cowpea mosaic virus nanoparticles and empty virus-like particles show distinct but overlapping immunostimulatory properties. J Virol 93 (21) e00129-19.