Description
Description
Description
Description
Twyman
Research
Management Ltd
Description
Specialist consultants in scientific project development, management and presentation

Review Articles (published before 2015)

 2014 


Angiari S, Constantin G (2014) Regulation of T-cell trafficking by mucin TIM-1. Trends Mol Med 20 (12) 675–684.


Arcalis E, Ibl V, Peters J, Melnik S, Stoger E (2014) The dynamic behavior of storage organelles in developing cereal seeds and its impact on the production of recombinant proteins. Front Plant Sci 5, 00439.


Chen J, Vandelle E, Bellin D, Delledonne M (2014) Detection and function of nitric oxide during the hypersensitive response in Arabidopsis thaliana: Where there's a will there's a way. Nitric Oxide 43, 81–88.


DalCorso G, Manara A, Piasentin S, Furini A (2014) Nutrient metal elements in plants. Metallomics 6 (10) 1770–1788.


Farré G, Blancquaert D, Capell T, Van Der Straeten D, Christou P, Zhu C (2014) Engineering complex metabolic pathways in plants. Annu Rev Plant Biol 65, 187–223.


Fischer R, Buyel JF, Schillberg S, Twyman RM (2014) Molecular farming in plants: the long road to the market. Biotechnol Agr Forest 68, 27–41.


Merlin M, Gecchele E, Capaldi S, Pezzotti M, Avesani L (2014) Comparative evaluation of recombinant protein production in different biofactories: The green perspective. Biomed Res Int 2014, 136419.


Miralpeix B, Sabalza M, Twyman RM, Christou P, Capell T (2014) Strategic patent analysis in plant biotechnology: terpenoid indole alkaloid metabolic engineering as a case study. Plant Biotechnol J 12 (2) 117–134.


Ritala A, Häkkinen ST, Schillberg S (2014) Molecular pharming in plant cell cultures – great future ahead? Pharma Bioproc 2 (3) 223–226.


Sabalza M, Christou P, Capell T (2014) Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks. Biotechnol Lett 36 (12) 2367–2379.


Salgado D, Fischer R, Schillberg S, Twyman RM, Rasche S (2014) Comparative evaluation of heterologous production systems for recombinant pulmonary surfactant protein D. Front Immunol 5, 623.


Shukla S, Dickmeis C, Nagarajan AS, Fischer R, Commandeur U, Steinmetz NF (2014) Molecular farming of fluorescent virus-based nanoparticles for optical imaging in plants, human cells and mouse models. Biomater Sci 2, 784–797.


Stoger E, Fischer R, Moloney M, Ma JK (2014) Plant molecular pharming for the treatment of chronic and infectious diseases. Annu Rev Plant Biol 65, 743–768.


Vamvaka E, Twyman RM, Christou P, Capell T (2014) Can plant biotechnology help to break the HIV-malaria link? Biotechnol Adv 32 (2) 575–582.


Visioli G, D’Egidio S, Sanangelantoni AM (2014) The rhizobiome of hyperaccumulators: future perspectives based on omics analysis and advanced microscopy. Front Plant Sci 5, 752.


Worden N, Girke T, Drakakaki G (2014) Endomembrane dissection using chemically induced bioactive clusters. Methods Mol Biol 1056, 159–168.



 2013 

 

Albajes R, Cantero-Martínez C, Capell T, Christou P, Farre A, Galceran J, López-Gatius F, Marin S, Martín-Belloso O, Motilva Ma J, Nogareda C, Peman J, Puy J, Recasens J, Romagosa I, Romero Ma P, Sanchis V, Savin R, Slafer GA, Soliva-Fortuny R, Viñas I, Voltas J (2013) Building bridges: an integrated strategy for sustainable food production throughout the value chain. Mol Breeding 32 (4) 743–770.


Angiari S, Constantin G (2013) Selectins and their ligands as potential immunotherapeutic targets in neurological diseases. Immunotherapy 5 (11) 1207–1220.


Arjó G, Portero M, Piñol C, Viñas J, Matias-Guiu X, Capell T, Bartholomaeus A, Parrott W, Christou P (2013) Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats. Transgenic Res 22 (2) 255–267.

 

Arcalis E, Stadlmann J, Rademacher T, Marcel S, Sack M, Altmann F, Stoger E (2013) Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins. Plant Mol Biol 83 (1-2) 105–117.

 

Barth S (2013) The SNAP-tag technology a versatile tool with many applications. Curr Pharm Des 19 (30) 5404–5405.

 

Berman J, Zhu C, Pérez-Massot E, Arjó G, Zorrilla-López U, Masip G, Banakar R, Sanahuja G, Farré G, Miralpeix B, Bai C, Vamvaka E, Sabalza M, Twyman RM, Bassié L, Capell T, Christou P (2013) Can the world afford to ignore biotechnology solutions that address food insecurity? Plant Mol Biol 83 (1–2) 5–19.

 

Brandt A, Vilcinskas A (2013) The fruit fly Drosophila melanogaster as a model for aging research. Adv Biochem Eng Biotechnol 135, 63–77.

Buiatti M, Christou P, Pastore G (2013) The application of GMOs in agriculture and in food production for a better nutrition: two different scientific points of view. Genes Nutr 8 (3) 255–270.


Christou P (2013) From medicinal plants to medicines in plants: plant factories for the production of valuable pharmaceuticals. Curr Pharm Des 19 (31) 5469–5470.

 

Christou P (2013) Plant genetic engineering and agricultural biotechnology 1983-2013. Trends Biotechnol 31 (3) 125–127.


Commisso M, Strazzer P, Toffali K, Stocchero M, Guzzo F (2013) Untargeted metabolomics: an emerging approach to determine the composition of herbal products. Comp Struct Biotechnol J 4 (5) e210301007.


Dalcorso G, Fasani E, Furini A (2013) Recent advances in the analysis of metal hyperaccumulation and hypertolerance in plants using proteomics. Frontiers Plant Sci 4, 280.


DalCorso G, Manara A, Furini A (2013) An overview of heavy metal challenge in plants: from roots to shoots. Metallomics 5 (9) 1117–1132. 

 

Fischer R, Ostafe R, Twyman RM (2013) Cellulases from insects. Adv Biochem Eng Biotechnol 136, 51–64.

 

Fischer R, Schillberg S, Buyel JF, Twyman RM (2013) Commercial aspects of pharmaceutical protein production in plants. Curr Pharm Des 19 (31) 5471–5477.

 

Gonçalves S, Romano A (2013) Micropropagation of Lavandula spp. Methods Mol Biol 11013, 189–198.

 

Gottschalk U (2013) Antibody–drug conjugates: the success of failure. Pharma Bioprocessing 1 (4) 311–313.


Gottschalk U (2013) Biomanufacturing: time for change? Pharma Bioprocessing 1 (1) 7–9.


Gottschalk U, Brorson K, Shukla AA (2013) Innovation in biomanufacturing: the only way forward. Pharma Bioprocessing 1 (2) 144–157.


Grevenstuk T, Romano A (2013) Aluminium speciation and internal detoxification mechanisms in plants: where do we stand? Metallomics 5(12) 1584–1594.


Hehmann-Titt G, Schiffer S, Berges N, Melmer G, Barth S (2013) Improving the therapeutic potential of human granzyme B for targeted cancer therapy. Antibodies 2 (1) 19–49.


Hofbauer A, Stoger E (2013) Subcellular accumulation and modification of pharmaceutical proteins in different plant tissues. Curr Pharm Des 19 (31) 5495–5502.

 

Hristodorov D, Fischer R, Linden L (2013) With or without sugar? (A)glycosylation of therapeutic antibodies. Mol Biotechnol 54 (3) 1056–1068.


Knorr E, Bingsohn L, Kanost MR, Vilcinskas A (2013) Tribolium castaneum as a model for high-throughput RNAi screening. Adv Biochem Eng Biotechnol 136, 163–178.


Kollewe C, Vilcinskas A (2013) Production of recombinant proteins in insect cells. Am J Biochem Biotechnol 9 (3) 255–271.


Masip G, Sabalza M, Pérez-Massot E, Banakar R, Cebrian D, Twyman RM, Capell T, Albajes R, Christou P (2013) Paradoxical EU agricultural policies on genetically engineered crops. Trends Plant Sci 18 (6) 312–324.


Melnik S, Stoger E (2013) Green factories for biopharmaceuticals. Curr Med Chem 20 (8) 1038–1046.

 

Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM, Capell T, Christou P (2013) Metabolic engineering of plant secondary products: which way forward? Curr Pharm Des 19 (31) 5622–5639.

 

Mukherjee K, Raju R, Fischer R, Vilcinskas A (2013) Galleria mellonella as a model host to study gut microbe homeostasis and brain infection by the human pathogen Listeria monocytogenes. Adv Biochem Eng Biotechnol 135, 27–39.


Paul MJ, Teh AYT, Twyman RM, Ma JKC (2013) Target product selection - where can molecular pharming make the difference? Curr Pharm Des 19 (31) 5478–5485.

 

Pérez-Massot E, Banakar R, Gómez-Galera S, Zorrilla-López U, Sanahuja G, Arjó G, Miralpeix B, Vamvaka E, Farré G, Rivera SM, Dashevskaya S, Berman J, Sabalza M, Yuan D, Bai C, Bassie L, Twyman RM, Capell T, Christou P, Zhu C (2013) The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints. Genes and Nutrition 8 (1) 29–41.

 

Sabalza M, Vamvaka E, Christou P, Capell T (2013) Seeds as a production system for molecular pharming applications: status and prospects. Curr Pharm Des 19 (31) 5543–5552.

 

Schillberg S, Raven N, Fischer R, Twyman RM, Schiermeyer A (2013) Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures. Curr Pharm Des 19 (31) 5531–5542.

 

Schott M, Wehrenfennig C, Gasch T, Vilcinskas A. Insect antenna-based biosensors for in situ detection of volatiles. Adv Biochem Eng Biotechnol136,101–122.

 

Shukla AA, Gottschalk U (2013) Single-use disposable technologies for biopharmaceutical manufacturing. Trends Biotechnol 31 (3) 147–154.

 

Steinmetz NF (2013) Viral nanoparticles in drug delivery and imaging. Mol Pharm 10 (1) 1–2.

 

Stöger E (2013) Editorial: from plant biotechnology to bio-based products. Biotechnol J. 8 (10) 1122–1123.


Twyman RM, Schillberg S, Fischer R (2013) Optimizing the yield of recombinant pharmaceutical proteins in plants. Curr Pharm Des 19 (31) 5486–5494.


Vilcinskas A (2013) Evolutionary plasticity of insect immunity. J Insect Physiol 59 (2) 123–129.

 

Will T, Vilcinskas A (2013) Aphid-proof plants: biotechnology-based approaches for aphid control. Adv Biochem Eng Biotechnol 136, 179–203.

 

Zenaro E, Rossi B, Angiari S, Constantin G (2013) Use of imaging to study leukocyte trafficking in the central nervous system. Immunol Cell Biol 91 (4) 271–280.


Zhu C, Sanahuja G, Yuan D, Farré G, Arjó G, Berman J, Zorrilla-López U, Banakar R, Bai C, Pérez-Massot E, Bassie L, Capell T, Christou P (2013) Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies. Plant Biotechno J 11 (2) 129–141.

 

Zorrilla-López U, Masip G, Arjó G, Bai C, Banakar R, Bassie L, Berman J, Farré G, Miralpeix B, Pérez-Massot E, Sabalza M, Sanahuja G, Vamvaka E, Twyman RM, Christou P, Zhu C, Capell T (2013) Engineering metabolic pathways in plants by multigene transformation. Int J Dev Biol. 57 (6-8) 565–576.



 2012 

 

Buiatti M, Christou P, Pastore G (2012) The application of GMOs in agriculture and in food production for a better nutrition: two different scientific points of view. Genes Nutr 8 (3) 255–270.


Farré G, Naqvi S, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RM, Capell T, Zhu C, Christou P (2012) Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway. Methods Mol Biol 847, 419–435.


Farré G, Zorrilla U, Zhu C, Christou P, Capell T (2012) Increasing the vitamin E content of food by in-plant production. CAB Reviews 7, 030, 1–10.


Fischer R, Schillberg S, Hellwig S, Twyman RM, Drossard J (2012) GMP issues for recombinant plant-derived pharmaceutical proteins. Biotechnol Adv 30 (2) 434–439.

 
Gómez-Galera S, Twyman RM, Sparrow PA, Van Droogenbroeck B, Custers R, Capell T, Christou P (2012) Field trials and tribulations -- making sense of the regulations for experimental field trials of transgenic crops in Europe. Plant Biotechnol J 10 (5) 511–523.


Gonçalves S, Romano A (2012) In vitro culture of lavenders (Lavandula spp.) and the production of secondary metabolites. Biotechnol Adv 31 (2) 166–174.


Gottschalk U, Brorson K, Shukla AA (2012) The need for innovation in biomanufacturing. Nature Biotechnol 30 (6) 489–492.


Ibl V, Stoger E (2012) The formation, function and fate of protein storage compartments in seeds. Protoplasma 249 (2) 379–392.


Khan I, Twyman RM, Arcalis E, Stoger E (2012) Using storage organelles for the accumulation and encapsulation of recombinant proteins. Biotechnol J 7 (9) 1099–1108.

 
Lico C, Santi L, Twyman RM, Pezzotti M, Avesani L (2012) The use of plants for the production of therapeutic human peptides. Plant Cell Rep 31 (3) 439–451.


Stoger E (2012) Plant bioreactors - the taste of sweet success. Biotechnol J 7 (4) 475–476.

 


 2011 

 

Bai C, Twyman RM, Farré G, Sanahuja G, Christou P, Capell T, Zhu C (2011) A golden era - pro-vitamin A enhancement in diverse crops. In Vitro Cell Dev Biol Plants 47 (2) 205221.


Farre G, Bai C, Twyman RM, Capell C, Christou P, Zhu C (2011) Nutritious crops producing multiple carotenoids - a metabolic balancing act. Trends Plant Sci 16 (10) 532–450.


Farré G, Naqvi S, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RM, Capell T, Zhu C, Christou P (2011) Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway. Methods Mol Biol 847, 419–435.


Farre G, Twyman RM, Zhu C, Capell T, Christou P (2011) Nutritionally enhanced crops and food security: scientific achievements versus political expediency. Curr Opin Biotechnol 22 (2) 245–251.

Naqvi S, Ramessar K, Farre G, Sabalza M, Miralpeix B, Twyman RM, Capell T, Christou P, Zhu C (2011) High value products from transgenic maize. Biotechnol Adv 29 (1) 40–53.

Noll GA, Muller B, Twyman RM, Prüfer D (2011) Native and artificial forisomes: functions and applications. Appl Microbiol Biotechnol 89 (6) 1675–1682.

Peters J, Stoger E (2011) Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies. Hum Vaccines 7 (3) 367–374.

Pokorski JK, Steinmetz NF (2011) The art of engineering viral nanoparticles. Mol Pharm 8 (1) 29–43.

Sabalza M, Miralpeix B, Twyman RM, Capell T, Christou P (2011) EU legitimizes GM crop exclusion zones. Nature Biotechnol 29 (4) 315–317.

Safarnejad MR, Salehi-Jouzani GR, Tabatabaie M, Twyman RM, Schillberg S (2011) Antibody-mediated resistance against plant pathogens. Biotechnol Adv 29 (6) 961–971.

Sanahuja G, Subhasappa RB, Twyman RM, Capell T, Christou P (2011) Bacillus thuringiensis - a century of research, development and commercial applications. Plant Biotechnol J 9 (3) 283–300.


Vandelle E, Delledonne M (2011) Peroxynitrite formation and function in plants. Plant Sci 181 (5) 534–539.


Yildiz I, Shukla S, Steinmetz NF (2011) Applications of viral nanoparticles in medicine. Curr Opin Biotechnol 22 (6) 901–908.

Yuan D, Bassie L, Sabalza M, Miralpeix B, Dashevskaya S, Farré G, Rivera SM, Subhasappa RB, Bai C, Sanahuja G, Arjo G, Avilla E, Zorrilla-Lopez U, Ugido N, Lopez A, Almacellas D, Zhu C, Capell T, Hahne G, Twyman RM, Christou P (2011) The potential impact of plant biotechnology on the Millennium Development Goals. Plant Cell Reports 30 (3) 249–265.



 2010 and earlier 

Farré G, Ramessar K, Twyman RM, Capell T, Christou P (2010) The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption. Curr Opin Plant Biol 13 (2) 219–225.


Farré G, Sanahuja G, Naqvi S, Bai C, Capell T, Zhu C, Christou P (2010) Travel advice on the road to carotenoids in plants. Plant Sci 179 (1–2) 28–48.

Gómez-Galera S, Rojas E, Sudhakar D, Zhu C, Pelacho AM, Capell T, Christou P (2010) Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Res 19 (2) 165–180.

Naqvi S, Farré G, Sanahuja G, Capell T, Zhu C, Christou P (2010) When more is better: multigene engineering in plants. Trends Plant Sci 15 (1) 48–56.

Peremarti A, Twyman RM, Gómez-Galera S, Naqvi S, Farré G, Sabalza M, Miralpeix B, Dashevskaya S, Yuan D, Ramessar K, Christou P, Zhu C, Bassie L, Capell T (2010) Promoter diversity in multigene transformation. Plant Mol Biol 73 (4-5) 363–378.

Ramessar K, Capell T, Twyman RM, Christou P (2010) Going to ridiculous lengths - the absurd coexistence regulations applied to GE crops in Europe. Nature Biotechnol 28 (2) 133136.


Ramessar K, Sabalza M, Miralpeix B, Capell T, Christou P (2010) Can microbicides turn the tide against HIV? Curr Pharm Des 16 (4) 468–485.


Schiermeyer A, Schillberg S (2010) Pharmaceuticals. Biotechnol Agr For 64, 221–235.


Steinmetz NF (2010) Viral nanoparticles as platforms for next-generation therapeutics and imaging devices. Nanomedicine 6 (5) 634–641.

Zhu C, Bai C, Sanahuja G, Yuan D, Farré G, Naqvi S, Shi L, Capell T, Christou P (2010) The regulation of carotenoid pigmentation in flowers. Arch Biochem Biophys 504 (1) 132141.


Barth S (2009) Recombinant immunotoxins - the next generation. Curr Pharm Des 15 (23) 2650–2651.


Gottschalk U (2009) Disposables in downstream processing. Adv Biochem Eng Biotechnol 115, 171–183.


Heinig U, Jennewein S (2008) Taxol: A complex diterpenoid natural product with an evolutionarily obscure origin. Afr J Biotechnol 8 (8) 2.


Hetzel C, Bachran C, Tur MK, Fuchs H, Stöcker M (2009) Improved immunotoxins with novel functional elements. Curr Pharm Des 15 (23) 2700–2711.

Ramessar K, Capell T, Twyman RM, Quemada H, Christou P (2009) Calling the tunes on transgenic crops - the case for regulatory harmony. Mol Breeding 23 (1) 99–112.

Sparrow PAC, Twyman RM (2009) Biosafety and risk assessment of plant-made pharmaceuticals. Methods Mol Biol 483, 341–353.

Truniger V, Aranda MA (2009) Recessive resistance to plant viruses. Adv Virus Res 75, 119–159.


Tur MK, Neef I, Jäger G, Teubner A, Stöcker M, Melmer G, Barth S (2009) Immunokinases, a novel class of immunotherapeutics for targeted cancer therapy. Curr Pharm Des 15 (23) 2693–2699.


Twyman RM, Ramessar K, Quemada H, Capell T, Christou P (2009) Plant biotechnology: the importance of being accurate. Trends Biotechnol 27 (11) 609–612.

Wullner U, Neef I, Tur MK, Barth S (2009) Targeted delivery of short interfering RNAs - strategies for in vivo delivery. Recent Pat Anticancer Drug Discov 4 (1) 1–8.

Gottschalk U (2008) Bioseparation in antibody manufacturing: the good, the bad and the ugly. Biotechnol Prog 24 (3) 496–503.

Kohli A, Christou P (2008) Stable transgenes bear fruit. Nature Biotechnol 26 (6) 653–654.


Ramessar K, Capell T, Christou P (2008) Molecular pharming in cereal crops. Phytochem Rev 7 (3) 579–592.


Ramessar K, Capell T, Twyman RM, Quemada H, Christou P (2008) Trace and traceability - a call for regulatory harmony. Nature Biotechnol 26 (9) 975–978.


Ramessar K, Sabalza M, Capell T, Christou P (2008) Maize plants: An ideal production platform for effective and safe molecular pharming. Plant Sci 174 (4) 409–419.

Spök A, Twyman RM, Fischer R, Ma JKC, Sparrow PAC (2008) Evolution of a regulatory framework for plant-made pharmaceuticals. Trends Biotechnol 26 (9) 506–517.


Yusibov V, Rabindran S (2008) Recent progress in the development of plant derived vaccines. Expert Rev Vaccines 7 (8) 1173–1183.


Gómez-Galera S, Pelacho AM, Gena A, Capell T, Christou P (2007) The genetic manipulation of medicinal and aromatic plants. Plant Cell Rep 26 (10) 1689–1715.

Ramessar K, Peremarti A, Gómez-Galera S, Naqvi S, Moralejo M, Muroz P, Capell T, Christou P (2007) Biosafety and risk assessment framework for selectable marker genes in transgenic crop plants: a case of the science not supporting the politics. Transgenic Res 16 (3) 261–280.

Schillberg S, Twyman RM (2007) Pharma-Planta: Recombinant pharmaceuticals from plants for human health. European Academy 43, 13–30.

Sparrow PAC, Irwin JA, Dale PJ, Twyman RM , Ma JKC (2007) Pharma-Planta: Road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgenic Res 16 (2) 147–161.

Zhu C, Naqvi S, Gomez-Galera S, Pelacho AM, Capell T, Christou P (2007) Transgenic strategies for the nutritional enhancement of plants. Trends Plant Sci 12 (12) 548–555.

Christou P, Capell T, Kohli A, Gatehouse JA, Gatehouse AM (2006) Recent developments and future prospects in insect pest control in transgenic crops. Trends Plant Sci 11 (6) 302–308.

Kohli A, Melendi PG, Abranches R, Capell T, Stoger E, Christou P (2006) The quest to understand the basis and mechanisms that control expression of introduced transgenes in crop plants. Plant Signal Behav 1 (4) 185–195.

Nolke G, Fischer R, Schillberg S (2006) Antibody-based metabolic engineering in plants. J Biotechnol 124 (1) 271–283.

Yusibov V, Rabindran S, Commandeur U, Twyman RM, Fischer R (2006) The potential of plant virus vectors for vaccine production. Drugs in R&D 7 (4) 203–217.


Altpeter F, Baisakh N, Beachy R, Bock R, Capell T, Christou P, Daniell H, Datta K, Datta S, Dix PJ, Fauquet C, Huang N, Kohli A, Mooibroek H, Nicholson L, Nguyen TT, Nugent G, Raemakers K, Romano A, Somers DA, Stoger E, Taylor N, Visser R (2005) Particle bombardment and the genetic enhancement of crops: myths and realities. Mol Breeding 15 (3) 305–327.

Ma JKC, Barros E, Bock R, Christou P, Dale PJ, Dix PJ, Fischer R, Irwin J, Mahoney R, Pezzotti M, Schillberg S, Sparrow P, Stoger E,Twyman RM (2005) Molecular farming for new drugs and vaccines. Current perspectives on the production of pharmaceuticals in transgenic plants. EMBO Reports 6 (7) 593–599.

Ma JKC, Chikwamba R, Sparrow P, Fischer R, Mahoney R,Twyman RM (2005) Plant-derived pharmaceuticals - The road forward. Trends Plant Sci 10 (12) 580–585.

Schillberg S,Twyman RM , Fischer R (2005) Opportunities for recombinant antigen and antibody expression in transgenic plants - technology assessment. Vaccine 23 (15) 17641769.


Stoger E, Ma JK, Fischer R, Christou P (2005) Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotechnol 16 (2) 167–173.

Stoger E, Sack M, Nicholson L, Fischer R, Christou P (2005) Recent progress in plantibody technology. Curr Pharm Des 11 (19) 2439–2457.

Twyman RM, Schillberg S, Fischer R (2005) Transgenic plants in the biopharmaceutical market. Expert Opin Emerg Drugs 10 (1) 185–218.


Wassenegger M (2005) The role of the RNAi machinery in heterochromatin formation. Cell 122 (1) 13–16.


Capell T, Christou P (2004) Progress in plant metabolic engineering. Curr Opin Biotechnol 15 (2) 148–154.

Capell T, Claparols I, Del Duca S, Bassie L, Miro B, Rodriguez-Montesinos J, Christou P, Serafini-Fracassini D (2004) Producing transglutaminases by molecular farming in plants: minireview article. Amino Acids 26 (4) 419–423.

Christou P, Twyman RM (2004) The potential of genetically enhanced plants to address food insecurity. Nutrition Res Rev 17 (1) 23–42.

Fischer R, Stoger E, Schillberg S, Christou P, Twyman RM (2004) Plant-based production of biopharmaceuticals. Curr Opin Plant Biol 7 (2) 152–158.

Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of recombinant proteins. Nature Biotechnol 22 (11) 1415–1422.


Nölke G, Fischer R, Schillberg S (2004) Antibody-based pathogen resistance in plants. J Plant Pathol 86 (1) 5–17.


Stoger E, Schillberg S, Twyman RM, Fischer R, Christou P (2004) Antibody production in transgenic plants. Methods Mol Biol 248, 301–318.

Twyman RM (2004) SNP discovery and typing technologies for pharmacogenomics. Curr Top Med Chem 4 (13) 1421–1429.

Commandeur U, Twyman RM, Fischer R (2003) The biosafety of molecular farming in plants. AgBiotechNet 5, ABN 110.

Fischer R, Twyman RM, Schillberg S (2003) Production of antibodies in plants and their use for global health. Vaccine 21 (7–8) 820–825.

Kohli A, Twyman RM, Abranches A, Wegel E, Shaw P, Christou P, Stoger E (2003) Transgene integration, organization and interaction in plants. Plant Mol Biol 52 (2) 247–258.

Ma JK, Drake PM, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4 (10) 794–805.

Nolke G, Fischer R, Schillberg S (2003) Production of therapeutic antibodies in plants. Expert Opin Biol Ther 3 (7) 1153–1162.

Schillberg S, Fischer R, Emans N (2003) Molecular farming of recombinant antibodies in plants. Cell Mol Life Sci 60 (3) 433–445.


Schillberg S, Fischer R, Emans N (2003) 'Molecular farming' of antibodies in plants. Naturwissenschaften 90 (4) 145–155.


Twyman RM, Primrose SB (2003) Techniques patents for SNP genotyping. Pharmacogenomics 4 (1) 67–79.

Twyman RM, Stoger E, Schillberg S, Christou P, Fischer R (2003) Molecular farming in plants: Host systems and expression technology. Trends Biotechnol 21 (12) 570–578.


Christou P (2002) No credible scientific evidence is presented to support claims that transgenic DNA was introgressed into traditional maize landraces in Oaxaca, Mexico. Transgenic Res 11 (1) iii–v.

Stoger E, Sack M, Fischer R, Christou P (2002) Plantibodies: applications, advantages and bottlenecks. Curr Opin Biotechnol 13 (2) 161–166.

Stoger E, Sack M, Perrin Y, Vaquero C, Torres E, Twyman RM, Christou P, Fischer R (2002) Practical considerations for pharmaceutical antibody production in different crop systems. Mol Breeding 9 (3) 149–158.


Twyman RM, Stoger E, Kohli A, Capell T, Christou P (2002) Selectable and screenable markers for rice transformation. Mol Methods Plant Analysis 22, 1–17.

Twyman RM, Stoger E, Kohli A, Christou P (2002) Foreign DNA: integration and expression in transgenic plants. Genet Eng Prin Methods 24,107–136.

Twyman RM, Jones EA (1995) The regulation of neuron-specific gene expression in the mammalian nervous system. J Neurogenet 10 (2) 67–101. 

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