Management Ltd
Specialist consultants in scientific project development, management and presentation

Review Articles, 2015-2019

 2019 and in press 

Armario Najera V, Twyman RM, Christou P, Zhu C (2019) Applications of multiplex genome editing in higher plants. Curr Opin Bitotechnol 59, 93102.  DOI

Buyel JF (2019) Plant molecular farming – integration and exploitation of side streams to achieve sustainable biomanufacturing. Front Plant Sci 9, 1893.  DOI

Fischer R, Holland T, Sack M, Schillberg S, Stoger E, Twyman RM, Buyel JF (2019) Glyco-engineering of plant-based expression systems. Adv Biochem Eng/Biotechnol (online first, 2/8/2018).  DOI

Jansing J, Schiermeyer A, Schillberg S, Fischer R, Bortesi L (2019) Genome editing in agriculture: technical and practical considerations. Int J Mol Sci 20 (12) 2888.  DOI

Röder J, Dickmeis C, Commandeur U (2019) Small, smaller, nano: New applications for Potato virus X in nanotechnology. Front Plant Sci 10, 158.  DOI 

Schillberg S, Raven N, Spiegel H, Rasche S, Buntru M (2019) Critical analysis of the commercial potential of plants for the production of recombinant proteins. Front Plant Sci 10, 720.  DOI

Schmitz C, Auza LG, Koberidze D, Rasche S, Fischer R, Bortesi L (2019) Conversion of chitin to defined chitosan oligomers: current status and future prospects. Marine Drugs 17 (8) 452.  DOI

Steinmetz NF (2019) Biological and evolutionary concepts for nanoscale engineering. EMBO Rep 20 (8) e48806.  DOI

Vilcinskas A (2019) Evolutionary ecology of parasitic fungi and their host insects. Fungal Ecol 38, 12–20.  DOI

Vilcinskas A (2019) Pathogens associated with invasive or introduced insects threaten the health and diversity of native species. Curr Opin Insect Sci 33, 43–48.  DOI


Buyel JF (2018) Plants as sources of natural and recombinant anticancer agents. Biotechnol Adv 36 (2) 506520.  DOI

Fasani E, Manara A, Martini F, Furini A, DalCorso G (2018) The potential of genetic engineering of plants for the remediation of soils contaminated with heavy metals. Plant Cell Env 41 (5) 12011232.  DOI

Hoffmann D, Ebrahimi M, Gerlach D, Salzig D, Czermak P (2018) Reassessment of inclusion body-based production as a versatile opportunity for difficult-to-express recombinant proteins. Crit Rev Biotechnol 38 (5) 729744.  DOI

Holland T, Buyel JF (2018) Bioreactor-based production of glycoproteins in plant cell suspension cultures. Methods Mol Biol 1674, 129146.  DOI

Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G (2018) Functional morphology of the blood–brain barrier in health and disease. Acta Neuropathol 135, 311–336.  DOI

Martins MH, Borges ML, Gonçalves T (2018) Attitudes towards inclusion in higher education in a Portuguese university. Int J Incl Ed 22 (5) 527542.  DOI

Petry F, Weidner T, Czermak P, Salzig D (2018) Three-dimensional bioreactor technologies for the cocultivation of human mesenchymal stem/stromal cells and beta cells. Stem Cells Int 2018, 2547098.  DOI

Pohlscheidt M, Kiss R, Gottschalk U (2018) An introduction to recent trends in the biotechnology industry: development and manufacturing of recombinant antibodies and proteins. Adv Biochem Eng/Biotechnol 165, 18.  DOI

Schubert M, Spiegel H, Schillberg S, Nölke G (2018) Aspergillus-specific antibodies – targets and applications. Biotechnol Adv 36 (4) 11671184.  DOI

Zhu C, Farré G, Zanga D, Lloveras J, Michelena A, Ferrio JP, Voltas J, Slafer G, Savin R, Albajes R, Eizaguirre M, Lopez C, Cantero-Martínez C, Díaz-Gómez J, Nogareda C, Moreno JA, Angulo E, Estany J, Pena RN, Tor M, Portero-Otin M, Eritja N, Arjó G, Serrano JCE, Matias-Guiu X, Twyman RM, Sandmann G, Capell T, Christou P (2018) High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition. Phytochem Rev 17 (2) 195209.  DOI


Buyel JF, Twyman RM, Fischer R (2017) Very-large-scale production of antibodies in plants: the biologization of manufacturing. Biotechnol Adv 35 (4) 458665.  DOI

Díaz-Gómez J, Twyman RM, Zhu C, Farré G, Serrano JCE, Portero-Otin M, Muñoz P, Sandmann G, Capell T, Christou P (2017) Biofortification of crops with nutrients: factors affecting utilization and storage. Curr Opin Biotechnol 44, 115123.  DOI

Edgue G, Twyman RM, Beiss V, Fischer R, Sack M (2017) Antibodies from plants for bionanomaterials. WIRES Nanomed Nanobiotechnol 9 (6) e1462.  DOI

Galante E, Temple T, Ladyman M, Gill PP (2017) The UK Ministry of Defence Project Orientated Environmental Management System (POEMS). Prop Expl Pyrotech 42 (1) 36–43.  DOI

Grau T, Vilcinskas A, Joop G (2017) Sustainable farming of the mealworm Tenebrio molitor for the production of food and feed. Z Naturforsch C 72 (910) 337349.  DOI

Hilscher J, Bürstmayr H, Stoger E (2017) Targeted modification of plant genomes for precision crop breeding. Biotechnol J 12 (1) 1600173.  DOI

Merlin M, Pezzotti M, Avesani L (2017) Edible plants for oral delivery of biopharmaceuticals. Br J Clin Pharmacol 83 (1) 7181.  DOI

Naqvi S, Moerschbacher BM (2017) The cell factory approach toward biotechnological production of high-value chitosan oligomers and their derivatives: an update. Crit Rev Biotechnol 37 (1) 1125.  DOI

Oppermann T, Busse N, Czermak P (2017) Mannheimia haemolytica growth and leukotoxin production for vaccine manufacturing – a bioprocess review. Elec J Biotechnol 28, 95–100.  DOI

Pietronigro EC, Della Bianca V, Zenaro E, Constantin G (2017) NETosis in Alzheimer’s disease. Front Immunol 8, 211.  DOI

Schetelig MF, Lee KZ, Otto S, Talmann L, Stökl J, Degenkolb T, Vilcinskas A, Halitschke R (2017) Environmentally sustainable pest control options for Drosophila suzukii. J Appl Entomol 142 (2) 3–17.  DOI

Steinmetz NF (2017) Enter the Nanoman. Nature Nanotechnol 12, 928.  DOI

Talmann L, Wiesner J, Vilcinskas A (2017) Strategies for the construction of insect P450 fusion enzymes. Z Naturforsch C 72 (910) 405415.  DOI

Tonk M, Vilcinskas A (2017) The medical potential of antimicrobial peptides from insects. Curr Top Med Chem 17 (5) 554–575.  DOI

Verheggen FJ, Vogel H, Vilcinskas A (2017) Behavioral and immunological features promoting the invasive performance of the Harlequin ladybird Harmonia axyridis. Front Ecol Evol 5, 156.  DOI

Vilcinskas A (2017) The impact of parasites on host insect epigenetics. Adv Insect Physiol 53, 145–165.  DOI

Zenaro E, Constantin G (2017) Targeting neuroinflammation in the treatment and prevention of Alzheimer’s disease. Drugs Future 42 (1) 2142.  DOI

Zenaro E, Piacentino G, Constantin G (2017) The blood–brain barrier in Alzheimer’s disease. Neurobiol Dis 107, 41–56.  DOI

Zhu C, Bortesi L, Baysal C, Twyman RM, Fischer R, Capell T, Schillberg S, Christou P (2017) Characteristics of genome editing mutations in cereal crops. Trends Plant Sci 22 (1) 3852.  DOI

Zischewski J, Fischer R, Bortesi L (2017) Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases. Biotechnol Adv 35 (1) 95–104.  DOI



Bellin D, Delledonne M, Vandelle E (2016) Detection of peroxynitrite in plants exposed to bacterial infection. Methods Mol Biol 1424, 191–200.  DOI

Bode L, Contractor N, Barile D, Pohl N, Prudden AR, Boons GJ, Jin YS, Jennewein S (2016) Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application. Nutr Rev 74 (10) 635644.  DOI

Boes A, Reimann A, Twyman RM, Fischer R, Schillberg S, Spiegel H (2016) A plant-based transient expression system for the rapid production of malaria vaccine candidates. Methods Mol Biol 1404, 597619.  DOI

Bolouri Moghaddam MR, Vilcinskas A, Rahnamaeian M (2016) Cooperative interaction of antimicrobial peptides with the interrelated immune pathways in plants. Mol Plant Pathol 17 (3) 464–471.  DOI

Bortesi L, Zhu C, Zischewski J, Perez L, Bassié L, Nadi R, Forni G, Lade SB, Soto E, Jin X, Medina V, Villorbina G, Muñoz P, Farré G, Fischer R, Twyman RM, Capell T, Christou P, Schillberg S (2016) Patterns of CRISPR/Cas9 activity in plants, animals and microbes. Plant Biotechnol J 14 (12) 22032216.  DOI

Damm T, Commandeur U, Fischer R, Usadel B, Klose H (2016) Improving the utilization lignocellulosic biomass by polysaccharide modification. Process Biochem 51 (2) 288–296.  DOI

Degenkolb T, Vilcinskas A (2016) Metabolites from nematophagous fungi and nematicidal natural products from fungi as an alternative for biological control. Part I: metabolites from nematophagous ascomycetes. Appl Microbiol Biotechnol 100 (9) 3799–3812.  DOI

Degenkolb T, Vilcinskas A (2016) Metabolites from nematophagous fungi and nematicidal natural products from fungi as alternatives for biological control. Part II: metabolites from nematophagous basidiomycetes and non-nematophagous fungi. Appl Microbiol Biotechnol 100 (9) 3813–3824.  DOI

Díaz-Gómez J, Marín S, Capell T, Sanchis V, Ramos AJ (2016) The impact of Bacillus thuringiensis technology on the occurrence of fumonisins and other mycotoxins in maize. World Mycotox J 9 (3) 475–486.  DOI

Gonçalves S, Romano A (2016) The medicinal potential of plants of from the genus Plantago (Plantaginaceae). Indust Crops Products 83, 231–226.  DOI

Humpert D, Ebrahimi M, Czermak P (2016) Membrane technology for the recovery of lignin: a review. Membranes 6 (3) 42.  DOI

Lambertz C, Ece S, Fischer R, Commandeur U (2016) Progress and obstacles in the production and application of recombinant lignin-degrading peroxidases. Bioengineered 7 (3) 145154.  DOI

Lee KL, Twyman RM, Fiering S, Steinmetz NF (2016) Virus-based nanoparticles as platform technologies for modern vaccines. WIREs Nanomed Nanobiotechnol 8 (4) 554578.  DOI

Mylonakis E, Podsiadlowski L, Muhammed M, Vilcinskas A (2016) Diversity, evolution and medical applications of insect antimicrobial peptides. Phil Trans 371 (1695) 20150290.  DOI

Peschen D, Schillberg S, Fischer R (2016) Antibody-mediated pathogen resistance in plants. Methods Mol Biol 1385, 273–291.  DOI

Pietronigro E, Zenaro E, Constantin G (2016) Imaging of leukocyte trafficking in Alzheimer's disease. Front Immunol 7, 33.  DOI

Rossi B, Constantin G (2016) Live imaging of immune responses in experimental models of multiple sclerosis. Front Immunol 7, 506.  DOI

Santos RB, Abranches R, Fischer R, Sack M, Holland T (2016) Putting the spotlight back on plant suspension cultures. Front Plant Sci 7, 297.  DOI

Schmitz C, Fritsch L, Fischer R, Schillberg S, Rasche S (2016) Statistical experimental designs for the production of secondary metabolites in plant cell suspension cultures. Biotechnol Lett 38 (12) 2007–2014.  DOI

Spohner SC, Schaum V, Quitmann H, Czermak P (2016) Kluyveromyces lactis: An emerging tool in biotechnology. J Biotechnol 222, 104-116.  DOI

Tonk M, Vilcinskas A, Rahnamaeian M (2016) Insect antimicrobial peptides: potential tools for the prevention of skin cancer. Appl Microbiol Biotechnol 100 (17) 73977405.  DOI

Tschofen M, Knopp D, Hood EE, Stoger E (2016) Plant molecular farming – much more than medicines. Ann Rev Analyt Chem 9, 271294.  DOI

Vilcinskas A (2016) The role of epigenetics in host–parasite coevolution: lessons from the model host insects Galleria mellonella and Tribolium castaneum. Zoology 119 (4) 273280.  DOI



Angiari S (2015) Selectin-mediated leukocyte trafficking during the development of autoimmune disease. Autoimmun Rev 14 (11) 984–995.  DOI

Berman J, Zorrilla-López U, Farré G, Zhu C, Sandmann G, Twyman RM, Capell T, Christou P (2015) Nutritionally important carotenoids as consumer products. Phytochem Rev 14 (5) 727–743.  DOI

Bortesi L, Fischer R (2015) The CRISPR/Cas9 system for plant genome editing and beyond. Biotechnol Adv 33 (1) 41–52.  DOI

Buyel JF (2015) Process development strategies in plant molecular farming. Curr Pharm Biotechnol 16 (11) 966–982.  DOI

Buyel JF, Fischer R, Twyman RM (2015) Extraction and downstream processing of plant-derived recombinant proteins. Biotechnol Adv 33 (6.1) 902–913.  DOI

Farré G, Twyman RM, Zhu C, Capell T, Christou P (2015) Knowledge-driven approaches for engineering complex metabolic pathways in plants. Curr Opin Biotechnol 32, 54–60.  DOI

Fischer R, Vasilev N, Twyman RM, Schillberg S (2015) High-value products from plants: the challenges of process optimization. Curr Opin Biotechnol 32, 156–162.  DOI

Furini A, Manara A, DalCorso G (2015) Environmental phytoremediation: plants and microorganisms at work. Front Plant Sci 6, 520.  DOI

Koudelka KJ, Pitek AS, Manchester M, Steinmetz NF (2015) Virus-based nanoparticles as versatile nanomachines. Annu Rev Virol 2 (1) 379–401.  DOI

Laibach N, Post J, Twyman RM, Schulze Gronover C, Prüfer D (2015) The characteristics and potential applications of structural lipid droplet proteins in plants. J Biotechnol 201, 15–27.  DOI

Mukherjee K, Twyman RM, Vilcinskas A (2015) Insects as models to study the epigenetic basis of diseases. Prog Biophys Mol Biol 118 (1–2) 69–78.  DOI

Rahnamaeian M, Vilcinskas A (2015) Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens. Appl Microbiol Biotechnol 99 (21) 8847–8855.  DOI

Sack M, Hofbauer A, Fischer R, Stoger E (2015) The increasing value of plant-made proteins. Curr Opin Biotechnol 32, 163–170.  DOI

Shukla S, Steinmetz NF (2015) Virus-based nanomaterials as positron emission tomography and magnetic resonance contrast agents: from technology development to translational medicine. WIREs Nanomed Nanobiotechnol 7 (5) 708–721.  DOI

Venturini L, Delledonne M (2015) Symbiotic plant-fungi interactions stripped down to the root. Nature Genet 47 (4) 309–310.  DOI

Vilcinskas A (2015) Pathogens as biological weapons of invasive species. PLOS Pathogens 11 (4) e1004714.  DOI

Vilcinskas A, Schmidtberg H, Estoup A, Tayeh A, Facon B, Vogel H (2015) Evolutionary ecology of microsporidia associated with the invasive ladybird Harmonia axyridis. Insect Sci 22 (3) 313–324.  DOI

Visioli G, D’Egidio S, Sanangelantoni AM (2014) The rhizobiome of hyperaccumulators: future perspectives based on omics analysis and advanced microscopy. Front Plant Sci 5, 752.  DOI

For earlier review articles we have helped to prepare, please click here

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