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Lambertz C, Eckert C, Fischer R, Commandeur U (2016) Kluyveromyces lactis as an expression host for enzymes that degrade lignocellulosic biomass. Cellulose Chem Tech 50 (3–4) 385–389. DOI
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Menzel S, Holland T, Boes A, Spiegel H, Fischer R, Buyel JF (2016) Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant-derived malaria vaccine candidates. Front Plant Sci 7, 159. DOI
Merlin M, Gecchele E, Arcalis E, Remelli S, Brozzetti A, Pezzotti M, Avesani L (2016) Enhanced GAD65 production in plants using the MagnICON transient expression system: optimization of upstream production and downstream processing. Biotechnol J 11 (4) 542–553. DOI
Mladenov R, Hristodorov D, Cremer C, Gresch G, Grieger E, Schenke L, Klose D, Amoury M, Woitok M, Jost E, Brümmendorf TH, Fendel R, Fischer R, Stein C, Thepen T, Barth S (2016) CD64-directed microtubule associated protein tau kills leukaemic blasts ex vivo. Oncotarget 7 (41) 67166–67174. DOI
Moghaddam MRB, Tonk M, Schreiber C, Salzig D, Czermak P, Vilcinskas A, Rahnamaeian M (2016) The potential of the Galleria mellonella innate immune system is maximized by the co-presentation of diverse antimicrobial peptides. Biol Chem 397 (9) 939–945. DOI
Moreno JA, Díaz-Gómez J, Nogareda C, Angulo E, Sandmann G, Portero-Otin M, Serrano JCE, Twyman RM, Capell T, Zhu C, Christou P (2016) The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage. Sci Rep 6, 35346. DOI
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Niesen J, Hehmann-Titt G, Woitok M, Fendel R, Barth S, Fischer R, Stein C (2016) A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor. Cancer Lett 374 (2) 229–240. DOI
Niesen J, Sack M, Seidel M, Fendel R, Barth S, Fischer R, Stein C (2016) SNAP-tag technology: a useful tool to determine affinity constants and other functional parameters of novel antibody fragments. Bioconjug Chem 27 (8) 1931–1941. DOI
Nogareda C, Moreno JA, Angulo E, Sandmann G, Portero M, Capell T, Zhu C, Christou P (2016) Carotenoid-enriched corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis. Plant Biotechnol J 14 (1) 97–108. DOI
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Pöppel AK, Kahl M, Baumann A, Wiesner J, Gökçen A, Beckert A, Preissner KT, Vilcinskas A, Franta Z (2016) A Jonah-like chymotrypsin from the therapeutic maggot Lucilia sericata plays a role in wound debridement and coagulation. Insect Biochem Mol Biol 70, 138–147. DOI
Rahnamaeian M, Cytrynska M, Zdybicka-Barabas A, Vilcinskas A (2016) The functional interaction between abaecin and pore-forming peptides indicates a general mechanism of antibacterial potentiation. Peptides 78, 17–23. DOI
Rasche S, Herwartz D, Schuster F, Fischer R, Schillberg S (2016) More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments. Sci Rep 6, 23371. DOI
Salzig D, Leber J, Merkewitz K, Lange MC, Köster N, Czermak P (2016) Attachment, growth and detachment of human mesenchymal stem cells in a chemically defined medium. Stem Cells Int 2016, 5246584. DOI
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Spohner SC, Czermak P (2016) Heterologous expression of Aspergillus terreus fructosyltransferase in Kluyveromyces lactis. New Biotechnol 33 (4) 473–479. DOI
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Vaas LAI, Witt G, Windshügel B, Bosin A, Serra G, Bruengger A, Winterhalter M, Gribbon P, Levy-Petelinkar CJ, Kohler M (2016) Electronic laboratory notebooks in a public–private partnership. PeerJ Comp Sci 2, e83.
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Vamvaka E, Arcalis E, Ramessar K, Evans A, O’Keefe BR, Shattock RJ, Medina V, Stoger E, Christou P, Capell T (2016) Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnol J 14 (6) 1427–1437.
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Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O’Keefe BR, Christou P, Capell T (2016) Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro. Plant Cell Rep 35 (6) 1309–1319.
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Vamvaka E, Twyman RM, Murad AM, Melnik S, Teh AYH, Arcalis E, Altmann F, Stoger E, Rech E, Ma JKC, Christou P, Capell T (2016) Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12. Plant Biotechnol J 14 (1) 97–108. DOI
Vasilev N, Boccard J, Lang G, Grömping U, Fischer R, Goepfert S, Rudaz S, Schillberg S (2016) Structured plant metabolomics for the simultaneous exploration of multiple factors. Sci Rep 6, 37390.
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Visser F, Müller B, Rose J, Prüfer D, Noll GA (2016) Forizymes – functionalised artificial forisomes as a platform for the production and immobilisation of single enzymes and multi-enzyme complexes. Sci Rep 6, 30839.
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Wiesner J, Hintz M, Reichenberg A, Ortmann R, Schlitzer M, Ziemann C, Fuhst R, Vilcinskas A, Jomaa H (2016) FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence 7 (6) 718–728. DOI
Woitok M, Klose D, Niesen J, Richter W, Abbas M, Stein C, d, Fendel R, Bialon M, Püttmann C, Fischer R, Barth S, Kolberg K (2016) The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F. Cancer Lett 381 (2) 323–330. DOI
Zanga D, Capell T, Zhu C, Christou P, Thangaraj H (2016) Freedom-to-operate analysis of a transgenic multivitamin corn variety. Plant Biotechnol J 14 (5) 1225–1240. DOI
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Abdellatef E, Will T, Koch A, Imani J, Vilcinskas A, Kogel KH (2015) Silencing the expression of the salivary sheath protein causes transgenerational feeding suppression in the aphid Sitobion avenae. Plant Biotechnol J 13 (6) 849–857. DOI
Anesi A, Stocchero M, Dal Santo S, Commisso M, Zenoni S, Ceoldo S, Tornielli GB, Siebert TE, Herderich M, Pezzotti M, Guzzo F (2015) Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome. BMC Plant Biol 15, 191.
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Baumann A, Lehmann R, Beckert A, Vilcinskas A, Franta Z (2015) Selection and evaluation of tissue specific reference genes in Lucilia sericata during an immune challenge. PLOS One 10 (8) e0135093. DOI
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Beiss V, Spiegel H, Boes A, Kapelski S, Scheuermayer M, Edgue G, Sack M, Fendel R, Reimann A, Schillberg S, Pradel G, Fischer R (2015) Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein. Biotechnol Bioeng 112 (7) 1297–1305. DOI
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Brehm H, Hristodorov D, Pardo A, Mladenov R, Niesen J, Fischer R, Tur MK, Barth S (2015) Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein. Cancer Lett 365 (2) 149–155.
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Bruckman MA, Randolph LN, Gulati NM, Stewart PL, Steinmetz NF (2015) Silica-coated Gd(DOTA)-loaded protein nanoparticles enable magnetic resonance imaging of macrophages. J Mater Chem B 2015 (3) 7503–7510.
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Buyel JF (2015) Controlling the interplay between Agrobacterium tumefaciens and plants during the transient expression of proteins. Bioengineered 6 (4) 242–244. DOI
Buyel JF, Buyel JJ, Hasse C, Fischer R (2015) The impact of Pseudomonas syringae type III effectors on transient protein expression in tobacco. Plant Biol 17 (2) 484–492. DOI
Buyel JF, Fischer R (2015) A juice extractor can simplify the downstream processing of plant-derived biopharmaceutical proteins compared to blade-based homogenizers. Process Biochem 5 (5) 859–866. DOI
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Buyel JF, Gruchow HM, Fischer R (2015) Depth filters containing diatomite achieve more efficient particle retention than filters solely containing cellulose fibers. Front Plant Sci 6, 1134. DOI
Buyel JF, Opdensteinen P, Fischer R (2015) Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins. Biotechnol J 10 (4) 584–591. DOI
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Chocarro C, Lloveras J (2015) The effect of row spacing on alfalfa seed and forage production under irrigated Mediterranean agricultural conditions. Grass Forage Sci 70 (4) 651–660. DOI
Cremer C, Braun H, Mladenov R, Hein L, Cong X, Jost E, Brümmendorf TH, Fischer R, Carloni P, Barth S, Nachreiner T (2015) Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo. Cancer Immunol Immunother 64 (12) 1575–1586. DOI
Cremer C, Vierbuchen T, Hein L, Fischer R, Barth S, Nachreiner T (2015) Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential. J Immunother 38 (3) 85–95. DOI
Dickmeis C, Honickel MM, Fischer R, Commandeur U (2015) Production of hybrid chimeric PVX particles using a combination of TMV and PVX-based expression vectors. Front Bioeng Biotechnol 3, 189. DOI
Epping J, van Deenen N, Niephaus E, Stolze A, Fricke J, Huber C, Eisenreich W, Twyman RM, Prüfer D, Schulze Gronover C (2015) A rubber transferase activator is necessary for natural rubber biosynthesis in dandelion. Nature Plants 1, 15048.
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Ferrarini A, Xumerle L, Griggio F, Garonzi M, Cantaloni C, Centomo C, Vargas SM, Descombes P, Marquis J, Collino S, Franceschi C, Garagnani P, Salisbury BA, Harvey JM, Delledonne M (2015) The use of non-variant sites to improve the clinical assessment of whole-genome sequence data. PLOS One 10 (7) e0132180. DOI
Filippetti I, Movahed N, Allegro G, Valentini G, Pastore C, Colucci E, Intrieri C (2015) Effect of post-veraison source limitation on the accumulation of sugar, anthocyanins and seed tannins in Vitis vinifera cv. Sangiovese berries. Aust J Grape Wine Res 21 (1) 90–100. DOI
Fitting J, Blume T, Ten Haaf A, Blau W, Gattenlöhner S, Tur MK, Barth S (2015) Generation of novel internalizing antibody fragments by phage display for immunotoxin-based treatment of acute myeloid leukemia. Monoclon Antib 7 (2) 390–402. DOI
Fritsch L, Fischer R, Schillberg S, Wamback C, Schröper F (2015) Next-generation sequencing is a robust strategy for the detection of zygosity in transgenic maize. Transgenic Res 24 (4) 615–623. DOI
Kaiser M, Pereira S, Pohl L, Ketelhut, Kemper B, Gorzelanny, Galla HJ, Moerschbacher BM, Goycoolea FM (2015) Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells. Sci Rep 5, 10048. DOI
Kapelski S, Boes A, Spiegel H, de Almeida M, Klockenbring T, Reimann A, Fischer R, Barth S, Fendel R (2015) Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody. Malaria J 14, 50. DOI
Kapelski S, de Almeida M, Fischer R, Barth S, Fendel R (2015) Antimalarial activity of granzyme B and its targeted delivery by a granzyme B–single-chain Fv fusion protein. Antimicrob Agents Chemother 59 (1) 669–672. DOI
Klinger J, Fischer R, Commandeur U (2015) Comparison of Thermobifida fusca cellulases expressed in Escherichia coli and Nicotiana tabacum indicates advantages of the plant system for the expression of bacterial cellulases. Front Plant Sci 6, 1047. DOI
Knorr E, Schmidtberg H, Arslan D, Bingsohn L, Vilcinskas A (2015) Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum. Biol Lett 11 (12) 20150885. DOI
Hamer SN, Cord-Landwehr S, Biarnés X, Planas A, Waegeman H, Moerschbacher BM, Kolkenbrock S (2015) Enzymatic production of defined chitosan oligomers with a specific pattern of acetylation using a combination of chitin oligosaccharide deacetylases. Sci Rep 5, 8716. DOI
Hristodorov D, Mladenov R, von Felbert V, Huhn M, Fischer R, Barth S, Thepen T (2015) Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies. Monoclon Antib 6 (5) 853–862. DOI
Laibach N, Hillebrand A, Twyman RM, Prüfer D, Schulze Gronover C (2015) Identification of a rubber elongation factor protein in Taraxacum brevicorniculatum that is localized on rubber particles and promotes rubber biosynthesis. Plant J 82 (4) 609–620. DOI
Lampis S, Santi C, Ciurli A, Andreolli M, Vallini G (2015) Promotion of arsenic phytoextraction efficiency in the fern Pteris vittata by the inoculation of As-resistant bacteria: a soil bioremediation perspective. Front Plant Sci 6, 80. DOI
Leufken CM, Moerschbacher BM, Dirks-Hofmeister ME (2015) Dandelion PPO-1/PPO-2 domain-swaps: The C-terminal domain modulates the pH optimum and the linker affects SDS-mediated activation and stability. Biochim Biophys Acta 1854 (2) 178–186. DOI
Ma JKC, Drossard J, Lewis D, Altmann F, Boyle J, Christou P, Cole T, Dale P, van Dolleweerd CJ, Isitt V, Katinger D, Lobedan M, Mertens H, Paul MJ, Rademacher T, Sack M, Hundleby PAC, Stiegler G, Stoger E, Twyman RM, Vcelar B, Fischer R (2015) Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants. Plant Biotechnol J 13 (8) 1106–1120. DOI
Madhuprakash J, El Gueddari NE, Moerschbacher BM, Podile AR (2015) Catalytic efficiency of chitinase-D on insoluble chitinous substrates was improved by fusing auxiliary domains. PLOS One 10 (1) e0116823. DOI
Madhuprakash J, El Gueddari NE, Moerschbacher BM, Podile AR (2015) Production of bioactive chitosan oligosaccharides using the hypertransglycosylating chitinase-D from Serratia proteamaculans. Bioresource Technol 198, 503–509. DOI
Maskus DJ, Bethke S, Seidel M, Kapelski S, Addai-Mensah O, Boes A, Edgü G, Spiegel H, Reimann A, Fischer R, Barth S, Klockenbring T, Fendel R (2015) Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10. Malar J 14, 276. DOI
Menchicchi B, Fuenzalida JP, Hensel A, Swamy MJ, David L, Rochas C, Goycoolea FM (2015) Biophysical analysis of the molecular interactions between polysaccharides and mucin. Biomacromolecules 16 (3) 924–935. DOI
Mendonça D, Luna S, Bettencourt S, Lopes MS, Monteiro L, Neves JD, Monjardino P, da Câmara Machado A (2015) In vitro propagation of Picconia azorica (Tutin) Knobl. (Oleaceae) an Azorean endangered endemic plant species. Acta Physiol Plant 37, 47. DOI
Milia G, Camiolo S, Avesani L, Porceddu A (2015) The dynamic loss and gain of introns during the evolution of the Brassicaceae. Plant J 82 (6) 915–924. DOI
Mladenov R, Hristodorov D, Thepen T, Cremer C, Hein L, Niesen J, Brehm H, Brümmendorf T, Jost E, Fischer R, Stockmeyer B, Barth S, Stein C (2015) The Fc-alpha receptor is a new immunotherapeutic target antigen for the treatment of myeloid leukaemia. Int J Cancer 137 (11) 2729–2738. DOI
Niesen J, Brehm H, Stein C, Berges N, Pardo A, Fischer R, Ten Haaf A, Gattenlöhner S, Tur MK, Barth S (2015) In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells. J Cancer Res Clin Oncol 141 (6) 1049–1061. DOI
Niesen J, Stein C, Brehm H, Hehmann-Titt G, Fendel R, Melmer G, Fischer R, Barth S (2015) Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activitu against different tumor entities. J Cancer Res Clin Oncol 141 (12) 2079–2095.
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O'Keeffe C, Champion S, Allsop D (2015) Demonstrating the effect of forensic firearm countermeasures: Bullet characteristics generated due to barrel modifications. Forensic Sci Int 257, 13–19. DOI
Popovic M, Prodanovic R, Ostafe R, Schillberg S, Fischer R, Gavrovic-Jankulovic M (2015) Yeast surface display is a novel tool for the rapid immunological characterization of plant plant-derived food allergens. Immunologic Res 61 (3) 230–239. DOI
Pöppel AK, Vogel H, Wiesner J, Vilcinskas A (2015) Combinatorial activities of antimicrobial peptides expressed in medicinal maggots of the blow fly Lucilia sericata against bacteria. Antimicrob Agents Chemother 59 (9) 2508–2514. DOI
Rahnamaeian M, Cytrynska M, Zdybicka-Barabas A, Dobslaff K, Twyman RM, Züchner T, Sadd B, Regoes R, Schmid-Hempel P, Vilcinskas A (2015) Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria. Proc R Soc B 282 (1806) 20150293. DOI
Raven N, Rasche S, Kuehn C, Anderlei T, Klöckner W, Schuster F, Fischer R, Henquet M, Bosch D, Büchs J, Schillberg S (2015) Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200 L orbitally shaken disposable bioreactor. Biotechnol Bioeng 112 (2) 308–321. DOI
Rettcher S, Jungk F, Kühn C, Krause HJ, Nölke G, Commandeur U, Fischer R, Schillberg S, Schröper F (2015) A simple and portable magnetic immunoassay for the rapid detection and sensitive quantitation of plant viruses. Appl Microbiol Biotechnol 81 (18) 3039–3048. DOI
Sack M, Rademacher T, Spiegel H, Boes A, Hellwig S, Drossard J, Stoger E, Fischer R (2015) From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants. Plant Biotechnol J 13 (8) 1094–1105. DOI
Santos-Carballal B, Aaldering LJ, Ritzefeld M, Pereira S, Sewald N, Moerschbacher BM, Götte M, Goycoolea FM (2015) Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells. Sci Rep 5, 13567. DOI
Schlich K, Hund-Rinke K (2015) Influence of soil properties on the effect of silver nanomaterials on microbial activity in five soils. Environ Poll 196 (1) 321–330. DOI
Schott M, Klein B, Vilcinskas A (2015) Sniffer bees: Detection of illicit drugs by trained honeybees (
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Schubert M, Houdelet M, Kogel KH, Fischer R, Schillberg S, Nölke G (2015) Thanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays). Transgenic Res 24 (5) 885–895. DOI
Shukla S, DiFranco NA, Wen AM, Commandeur U, Steinmetz NF (2015) To target or not to target: active vs. passive tumor homing of filamentous nanoparticles based on Potato virus X. Cel Mol Bioeng 8 (3) 433–444. DOI
Shukla S, Eber FJ, Nagarajan AS, DiFranco NA, Schmidt N, Wen AM, Eiben S, Twyman RM, Wege C, Steinmetz NF (2015) The impact of aspect ratio on the biodistribution and tumor homing of rigid soft-matter nanorods. Adv Healthc Mater 4 (6) 874–882. DOI
Sonnack L, Kampe S, Muth-Köhne E, Erdinger L, Henny N, Hollert H, Schäfers C, Fenske M (2015) Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos. Neurotoxicol Teratol 50, 33–42. DOI
Spohner SC, Zahn D, Schaum V, Quitmann H, Czermak P (2015) Recombinant alpha-L-rhamnosidase from Aspergillus terreus in selective trimming of alpha-L-rhamnose from steviol glycosides. J Mol Cat B: Enzymatic 122 (12) 248–254. DOI
Spiegel H, Boes A, Kastilan R, Kapelski S, Edgue G, Beiss V, Chubodova I, Schillberg S, Reimann A, Fischer R (2015) The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines. Biotechnol J 10 (10) 1651–1659. DOI
Spiegel H, Boes A, Voepel N, Beiss V, Edgue G, Rademacher T, Sack M, Schillberg S, Reimann A, Fischer R (2015) Application of a scalable plant transient gene expression platform for malaria vaccine development. Front Plant Sci 6, 1169. DOI
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Valdés O, Vergara CE, Camarada MB, Carrasco-Sánchez V, Nachtigall FM, Tapia J, Fischer R, González-Nilo FD, Santos LS. Synthesis and characterization of an insoluble polymer based on polyamidoamine: applications for the decontamination of metals in aqueous systems.J Environ Managemt 147, 321–329. DOI
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Will T, Vilcinskas A (2015) The structural sheath protein of aphids is required for phloem feeding. Insect Biochem Mol Biol 57, 34–40. DOI
Zenaro E, Pietronigro E, Bianca VD, Piacentino G, Marongiu L, Budui S, Turano E, Rossi B, Angiari S, Dusi S, Montresor A, Carlucci T, Nanì S, Tosadori G, Calciano L, Catalucci D, Berton G, Bonetti B, Constantin G (2015) Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nature Med 21 (8) 880–886. DOI
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