Original Research Papers

 2017 and in press 


Bai C, Capell T, Sandmann G, Christou P, Zhu C (2017) Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous ß-carotene hydroxylase activity in rice endosperm. Transgenic Res 26 (1) 13–23.  DOI

Banakar R, Alvarez Fernández Á, Abadía J, Capell T, Christou P (2017) The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport. Plant Biotechnol J 15 (4) 423–432.  DOI

Bauerschlag D, Meinhold-Heerlein I, Maass N, Bleilevens A, Bräutigam K, Al Rawashdeh W, Di Fiore S, Haugg AM, Gremse F, Steitz J, Fischer R, Stickeler E, Barth S, Hussain AF (2017) Detection and specific elimination of EGFR+ ovarian cancer cells using a near infrared photoimmunotheranostic approach. Pharm Res 34 (4) 696–703.  DOI 

Baumann A, Skaljac M, Lehmann R, Vilcinskas A, Franta Z (2017) Urate oxidase produced by Lucilia sericata medicinal maggots is localized in Malpighian tubes and facilitates allantoin production. Insect Biochem Mol Biol 83, 44–53.  DOI

Berges N, Arens K, Kreusch V, Fischer R, Di Fiore S (2017) Toward discovery of novel microtubule targeting agents: A SNAP-tag-based high-content screening assay for the analysis of microtubule dynamics and cell cycle progression. SLAS Discov 22 (4) 387–398.  DOI

Berman J, Zorrilla-López U, Medina V, Farré G, Sandmann G, Capell T, Christou P, Zhu C (2017) The Arabidopsis thaliana ORANGE (AtOR) gene promotes carotenoid and ketocarotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools. Plant Cell Rep (online first).  DOI

Bingsohn L, Knorr E, Billion A, Narva KE, Vilcinskas A (2017) Knockdown of genes in the Toll pathway reveals new lethal RNAi targets for insect pest control. Insect Mol Biol 26 (1) 92102.  DOI

Bolouri Moghaddam MR, Vilcinskas A, Rahnamaeian M (2017) The insect-derived antimicrobial peptide metchnikowin targets Fusarium graminearum ß(1,3) glucanosyltransferase Gel1, which is required for the maintenance of cell wall integrity. Biol Chem 398 (4) 491–498.  DOI

Busse N, Kraume M, Czermak P (2017) Modeling the design and operational mode of a continuous membrane reactor for enzymatic lignin modification. Biochem Eng J 124, 88–98.  DOI

Buyel JF, Gruchow H, Wehner M (2017) A rapid laser probing method facilitates the non-invasive and contact-free determination of leaf thermal properties. J Vis Exp (119) e54835.  DOI  

Chouman K, Woitok M, Mladenov R, Kessler C, Weinhold E, Hanz G, Fischer R, Meinhold-Heerlein I, Bleilevens A, Gresch G, Haugg AM, Zeppernick F, Bauerschlag D, Maass N, Stickeler E, Kolberg K, Hussain AF (2017) Fine tuning antibody conjugation methods using SNAP-tag technology. Anti-Cancer Agents Med Chem (online first).  DOI

Commisso M, Anesi A, Dal Santo S, Guzzo F (2017) Performance comparison of electrospray ionization and atmospheric pressure chemical ionization in untargeted and targeted liquid chromatography/mass spectrometry based metabolomics analysis of grapeberry metabolites. Rapid Commun Mass Spec 31 (3) 292–300.  DOI

Ece S, Lambertz C, Fischer R, Commandeur U (2017) Heterologous expression of a Streptomyces cyaneus laccase for biomass modification applications. AMB Express 7, 86.  DOI  

Fan R, Ebrahimi M, Czermak P (2017) Anaerobic membrane bioreactor for continuous lactic acid fermentation. Membranes 7 (2) 26.  DOI

Fan R, Ebrahimi M, Quitmann H, Czermak P (2017) Lactic acid production in a membrane bioreactor system with thermophilic Bacillus coagulans: online monitoring and process control using an optical sensor. Separation Sci Technol 52 (2) 352–363.  DOI

Fasani E, DalCorso G, Varotto C, Li M, Visioli G, Mattarozzi M, Furini A (2017) The MTP1 promoters from Arabidopsis halleri reveal cis-regulating elements for the evolution of metal tolerance. New Phytol 214 (4) 1614–1630.  DOI

Grein TA, Schwebel F, Kress M, Loewe D, Dieken H, Salzig D, Weidner T, Czermak P (2017) Screening different host cell lines for the dynamic production of measles virus. Biotechnol Prog (online first).  DOI

Havenith H, Kern K, Rautenberger P, Spiegel H, Szardenings M, Ueberham E, Lehmann J, Buntru M, Vogel S, Treudler R, Fischer R, Schillberg S (2017) Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants. Biotechnol J 12 (2) 1600441.  DOI

Houdelet M, Galinski A, Holland T, Wenzel K, Schillberg S, Buyel JF (2017) Animal component-free Agrobacterium tumefaciens cultivation media for better GMP-compliance increases biomass yield and pharmaceutical protein expression in Nicotiana benthamiana. Biotechnol J 12 (4) (online first).  DOI

Kapusi E, Corcuera-Gomes M, Melnik S, Stoger E (2017) Heritable genomic fragment deletions and small indels in the putative ENGase gene induced by CRISPR/Cas9 in barley. Front Plant Sci 8, 540.  DOI 

Kumar M, Ladyman MK, Mai N, Temple T, Coulon F (2017) Release of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) from polymer-bonded explosives (PBXN-109) into water by artificial weathering. Chemosphere 169, 604–608.  DOI

Leber J, Barekzai J, Blumenstock M, Pospisil B, Salzig D, Czermak P (2017) Microcarrier choice and bead-to-bead transfer for human mesenchymal stem cells in serum-containing and chemically defined media. Process Biochem (online first).  DOI

Luna-Ramirez K, Tonk M, Rahnamaeian M, Vilcinskas A (2017) Bioactivity of natural and engineered antimicrobial peptides from venom of the scorpions Urodacus yaschenkoi and U. manicatus. Toxins (Basel) 9 (1) 22.  DOI

Melnik S, Neumann AC, Karongo R, Dirndorfer S, Stübler M, Ibl V, Niessner R, Knopp D, Stoger E (2017) Cloning and plant-based production of antibody MC10E7 for a lateral flow immunoassay to detect [4-arginine]microcystin in fresh water. Plant Biotechnol J (online first).  DOI 

Mukherjee K, Grizanova E, Chertkova E, Lehmann R, Dubovskiy I, Vilcinskas A (2017) Experimental evolution of resistance against Bacillus thuringiensis in the insect model host Galleria mellonella results in epigenetic modifications. Virulence (online first).  DOI

Nesler A, DalCorso G, Fasani E, Manara A, Di Sansebastiano GP, Argese E, Furini A (2017) Functional components of the bacterial CzcCBA efflux system reduce cadmium uptake and accumulation in transgenic tobacco plants. New Biotechnol 35, 54–61.  DOI

Özdemir S, Heerd D, Quitmann H, Zhang Y, Fraatz MA, Zorn H, Czermak P (2017) Process parameters affecting the synthesis of natural flavors by shiitake (Lentinula edodes) during the production of a non-alcoholic beverage. Beverages 3 (2) 20.  DOI

Schreiber C, Müller H, Birrenbach O, Klein M, Heerd D, Weidner T, Salzig D, Czermak P (2017) A high-throughput expression screening platform to optimize the production of antimicrobial peptides. Microbial Cell Fact 16 (1) 29.  DOI

Stolze A, Wanke A, van Deened N, Greyer R, Prüfer D, Schulze Gronover C (2017) Development of rubber-enriched dandelion varieties by metabolic engineering of the inulin pathway. Plant Biotechnol J 15 (6) 740–753.  DOI

Vandelle E, Puttilli MR, Chini A, Devescovi G, Venturi V, Polverari A (2017) Application of chemical genomics to plant–bacteria communication: a high-throughput system to identify novel molecules modulating the induction of bacterial virulence genes by plant signals. Methods Mol Biol 1610, 297–314.  DOI

Vilcinskas A, Vogel H (2017) Seasonal phenotype-specific transcriptional reprogramming during metamorphosis in the European map butterfly Araschnia levana. Ecol Evol 6 (11) 34763485.  DOI

Vogel H, Schmidtberg H, Vilcinskas A (2017) Comparative transcriptomics of three ladybird species supports a role for immunity in invasion biology. Dev Comp Immunol 67, 452–456.  DOI

Vogel H, Shukla SP, Engl T, Weiss B, Fischer R, Steiger S, Heckel DG, Kaltenpoth M, Vilcinskas A (2017) The digestive and defensive basis of carcass utilization by the burying beetle and its microbiota. Nature Commun 8, 15186.  DOI

Will T, Schmidtberg H, Vilcinskas A (2017) Heat shock protein 83 plays pleiotropic roles in embryogenesis, longevity and fecundity in the pea aphid Acyrthosiphon pisum. Dev Genes Evo 227 (1) 1–9.  DOI

Zitzmann J, Weidner T, Czermak P (2017) Optimized expression of the antimicrobial peptide Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells. Cytotechnology 69 (2) 371–379.  DOI

Zheng Z, Tharmalingam N, Liu Q, Jayamani E, Kim W, Fuchs BB, Zhang R, Vilcinskas A, Mylonakis E (2017) The synergistic efficacy of Aedes aegypti antimicrobial peptide cecropin A2 and tetracycline against Pseudomonas aeruginosa. Antimicrob Agents Chemother (online first).  DOI



Addai-Mensah O, Seidel M, Amidu N, Maskus DJ, Kapelski S, Breuer G, Franken C, Owusu-Dabo E, Frempong M, Rakotozandrindrainy R, Schinkel H, Reimann A, Klockenbring T, Barth S, Fischer R, Fendel R (2016) Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria. Malaria J 15 (1) 65.  DOI

Allegro G, Pastore C, Valentini G, Muzzi E, Filippetti I (2016) Influence of berry ripeness on accumulation, composition and extractability of skin and seed flavonoids in cv. Sangiovese (V. vinifera L). J Sci Food Agric 96 (13) 4553–4559.  DOI

Amoury M, Bauerschlag D, Zeppernick F, von Felbert V, Berges N, Di Fiore S, Mintert I, Bleilevens A, Maass N, Bräutigam K, Meinhold-Heerlein I, Stickeler E, Barth S, Fischer R, Hussain AF (2016) Photoimmunotheranostic agents for triple-negative breast cancer diagnosis and therapy that can be activated on demand. Oncotarget 7 (34) 54925–54936.  DOI

Andreolli M, Lampis S, Brignoli P, Vallini G (2016) Trichoderma longibrachiatum Evx1 is a fungal biocatalyst suitable for the remediation of soils contaminated with diesel fuel and polycyclic aromatic hydrocarbons. Environ Sci Pollut Res Int 23 (9) 9134–9143.  DOI

Andreolli M, Lampis S, Zapparoli G, Angelini E, Vallini G (2016) Diversity of bacterial endophytes in 3 and 15 year-old grapevines of Vitis vinifera cv. Corvina and their potential for plant growth promotion and phytopathogen control. Microbiol Res 183, 42–52.  DOI

Arfi ZA, Hellwig S, Drossard J, Fischer R, Buyel JF (2016) Polyclonal antibodies for the specific detection of tobacco host cell proteins can be generated more efficiently following RuBisCO depletion and the removal of endotoxins. Biotechnol J 11 (4) 507–518.  DOI

Ariani P, Regaiolo A, Lovato A, Giorgetti A, Porceddu A, Camiolo S, Wong D, Castellarin S, Vandelle E, Polverari A (2016) Genome-wide characterisation and expression profile of the grapevine ATL ubiquitin ligase family reveal biotic and abiotic stress-responsive and development-related members. Sci Rep 6, 38260.  DOI 

Bai C, Capell T, Berman J, Medina V, Sandmann G, Christou P, Zhu C (2016) Bottlenecks in carotenoid biosynthesis and accumulation in rice endosperm are influenced by the precursor–product balance. Plant Biotechnol J 14 (1) 195–205.  DOI

Baysal C, Bortesi L, Zhu C, Farré G, Schillberg S, Christou P (2016) CRISPR/Cas9 activity in the rice OsBEIIb gene does not induce off-target effects in the closely related paralog OsBEIIa. Mol Breeding 36, 108.  DOI

Beckert A, Wiesner J, Schmidtberg H. Lehmann R, Baumann A, Vogel H, Vilcinskas A (2016) Expression and characterization of a recombinant i-type lysozyme from the harlequin ladybird beetle Harmonia axyridis. Insect Mol Biol 25 (3) 202–215.  DOI

Berman J, Sheng Y, Gomez Gomez L, Veiga T, Ni X, Farré G, Capell T, Guitián J, Guitián P, Sandmann G, Christou P, Zhu C (2016) Red anthocyanins and yellow carotenoids form the color of orange-flower gentian (Gentiana lutea var. aurantiaca).  PLOS One 11 (9) e0162410.  DOI 

Bialon M, Grezella C, Schellenberg L, Sieben T, Pham AT, Fischer R, Barth S, Püttmann C, Stein C (2016) A monoclonal antibody that discriminates between SNAP-tagged and CLIP-tagged proteins. Monoclon Antib Immunodiagn Immunother  35 (3) 141–147.  DOI

Bingsohn L, Knorr E, Vilcinskas A (2016) The model beetle Tribolium castaneum can be used as an early-warning system for transgenerational epigenetic effects caused by pharmaceuticals. Comp Biochem Biophys 185–186, 57–64.  DOI

Boes A, Spiegel H, Kastilan R, Bethke S, Voepel N, Chudobová I, Bolscher JM, Dechering KJ, Fendel R, Buyel J, Reimann A, Schillberg S, Fischer R (2016) Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail. Malaria J 15 (1) 279.  DOI

Busse N, Fuchs F, Kraume M, Czermak P (2016) Treatment of enzyme initiated delignification reaction mixtures with ceramic ultrafiltration membranes - experimental investigations and modeling approach. Separation Sci Technol 51 (9) 15467–1565.  DOI

Buyel JF (2016) Numeric simulation can be used as a quality-by-design approach for host cell protein precipitation during the heat treatment of tobacco leaves. Biochem Eng J (109) 118–126.  DOI

Buyel JF (2016) Procedure to evaluate the efficiency of flocculants for the removal of dispersed particles from plant extracts. J Vis Exp (110) e53940.  DOI

Buyel JF, Gruchow HM, Fischer R (2016) Depth filters containing diatomite achieve more efficient particle retention than filters solely containing cellulose fibers. Front Plant Sci 6, 1134.  DOI

Buyel JF, Gruchow HM, Tödter N, Wehner M (2016) Determination of the thermal properties of leaves by non-invasive contact-free laser probing. J Biotechnol 217, 100–108.  DOI

Buyel JF, Hubbuch J, Fischer R (2016) Comparison of tobacco host cell protein removal methods by blanching intact plants or by heat treatment of extracts. J Vis Exp (114) e54343.   DOI

Camiolo S, Melito S, Porceddu A (2016) New insights into the interplay between codon bias determinants in plants. DNA Res 22 (6) 461–470.  DOI

Commisso M, Toffali K, Strazzer P, Stocchero M, Ceoldo S, Baldan B, Levi M, Guzzo F (2016) Impact of phenylpropanoid compounds on heat stress tolerance in carrot cell cultures. Front Plant Sci 7, 1439.  DOI

Costa MP, Feitosa ACS, Oliveira FCE, Cavalcanti BC, da Silva EN, Dias GG, Sales FAM, Sousa BL, Barroso-Neto IL, Pessoa C, Caetano EWS,  Di Fiore S , Fischer R, Ladeira LO, Freire VN (2016) Controlled release of nor-ß-lapachone by PLGA microparticles: a strategy for improving cytotoxicity against prostate cancer cells. Molecules 21 (7) 873.  DOI

Cremonini E, Zonaro E, Donini M, Lampis S, Boaretti M, Dusi S, Melotti P, Lleo MM, Vallini G (2016) Biogenic selenium nanoparticles: characterization, antibacterial antimicrobial activity and effects on human dendritic cells and fibroblasts. Microb Boitechnol 9 (6) 758–771.  DOI

Dal Santo S, Commisso M, D’Incà E, Anesi A, Stocchero M, Zenoni S, Ceoldo S, Tornielli GB, Pezzotti M, Guzzo F (2016) The terroir concept interpreted through grape berry metabolomics and transcriptomics. J Vis Exp (116) e54410.  DOI

Dal Santo S, Fasoli M, Negri S, D’Incà E, Vicenzi N, Guzzo F, Tornielli GB, Pezzotti M, Zenoni S (2016) Plasticity of the berry ripening program in a white grape variety. Front Plant Sci 7, 970.  DOI

Dal Santo S, Palliotti A, Zenoni S, Tornielli GB, Fasoli M, Paci P, Tombesi S, Frioni T, Silvestroni O, Bellincontro A, d'Onofrio C, Matarese F, Gatti M, Poni S, Pezzotti M (2016) Distinct transcriptome responses to water limitation in isohydric and anisohydric grapevine cultivars. BMC Genom 17 (1) 815.  DOI

Damm T, Spiegel H, Barth S, Fischer R, Naehring J (2016) Development of a cystatin C specific bioassay for integration into an implantable biochip system. PLOS One 11 (1) e0147177.  DOI

de Bruin NMWJ, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, Häußler A, Tegeder I, Geisslinger G, Parnham MJ (2016) Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav Brain Res 300, 160–174.  DOI

Degenkolb T Götze L, von Döhren H, Vilcinskas A, Brückner H (2016) Sequences of stilboflavin C: Towards the peptaibiome of the filamentous fungus Stilbella (=Trichoderma) flavipes. J Peptide Sci 22 (8) 517–524.  DOI

Deidda A, Buffa F, Linaldeddu BT, Pinna C, Scanu B, Deiana V, Satta A, Franceschini A, Floris I (2016) Emerging pests and diseases threaten Eucalyptus camaldulensis plantations in Sardinia, Italy. iForest 9, 883–891.  DOI

Ebrahimi M, Busse N, Kerker S, Schmitz O, Hilpert M, Czermak P (2016) Treatment of the bleaching effluent from sulfite pulp production by ceramic membrane filtration. Membranes 6 (1) 7.  DOI 

Elía M, Savin R, Slafer GA (2016) Fruiting efficiency in wheat: physiological aspects and genetic variation among modern cultivars. Field Crops Res 191, 83–90.  DOI

Eritja N, Arjo G, Santacana M, Gatius S, Ramírez-Núnez O, Arcal L, Serrano JCE, Pamplona R, Dolcet X, Piñol C, Christou P, Matias-Guiu X, Portero-Otín M (2016) Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice. Biochim Biophys Acta 1862 (4) 526–535.  DOI

Fan R, Ebrahimi M, Quitmann H, Aden M, Czermak P (2016) An innovative optical sensor for the online monitoring and control of biomass concentration in a membrane bioreactor system for lactic acid production. Sensors 16 (3) 411.  DOI

Fasoli M, Dell'Anna R, Dal Santo S, Balestrini R, Sanson A, Pezzotti M, Monti F, Zenoni S (2016) Pectins, hemicelluloses and celluloses show specific dynamics in the internal and external surfaces of grape berry skin during ripening. Plant Cell Physiol 57 (6) 1332–1349.  DOI

Franta Z, Vogel H, Lehmann R, Rupp O, Goesmann A, Vilcinskas A (2016) Next generation sequencing identifies five major classes of potentially therapeutic enzymes secreted by Lucilia sericata medical maggots. BioMed Res Int 2016, 8285482.  DOI

Fritsch L, Soeur R, Hansen C, Fischer R, Schillberg S,  Schröper F (2016) Next-generation sequencing of amplicons is a rapid and reliable method for the detection of polymorphisms relevant for barley breeding. Mol Breeding 36, 83.  DOI

Fuenzalida JP, Nareddy PK, Moreno-Villoslada I, Moerschbacher BM, Swamy MJ, Pan S, Ostermeier M, Goycoolea FM (2016) On the role of alginate structure in complexing with lysozyme and application for enzyme delivery. Food Hydrocoll 53, 239–248.  DOI

Gaida SM, Liedtke A, Jentges AH, Engels B, Jennewein S (2016) Metabolic engineering of Clostridium cellulolyticum for the production of n-butanol from crystalline cellulose. Microb Cell Fact 15 (1) 6.  DOI

Grein TA, Leber J, Blumenstock M, Petry F, Weidner T, Salzig D, Czermak P (2016) Multiphase mixing characteristics in a microcarrier-based stirred tank bioreactor suitable for human mesenchymal stem cell expansion. Process Biochemistry 51 (9) 1109–1119.  DOI

Hoang KP, Teo TM, Ho TX, Le VS (2016) Mechanisms of sex determination and transmission ratio distortion in Aedes aegypti. Parasites & Vectors 9, 49.  DOI

Hofbauer A, Melnik S, Tschofen M, Arcalis E, Phan HT, Gresch U, Lampel J, Conrad U, Stoger E (2016) The encapsulation of hemagglutinin in protein bodies achieves a stronger immune response in mice than the soluble antigen. Front Plant Sci 7, 142.  DOI

Hristodorov D, Mladenov R, Fischer R, Barth S, Thepen T (2016) Fully-human MAP-fusion protein selectively targets and eliminates proliferating CD64+ M1 macrophages. Immunol Cell Biol 94 (5) 470478.  DOI

Hussain J, Chen J, Locato V, Sabetta W, Behera S, Cimini S, Griggio F, Martínez-Jaime S, Graf A, Bouneb M, Pachaiappan R, Fincato P, Blanco E, Costa A, De Gara L, Bellin D, Concetta de Pinto M, Vandelle E (2016) Constitutive cyclic GMP accumulation in Arabidopsis thaliana compromises systemic acquired resistance induced by an avirulent pathogen by modulating local signals. Sci Rep 6, 36423.  DOI

Jacobs CGC, Steiger S, Heckel DG, Vilcinskas A, Vogel H (2016) Sex, offspring and carcass determine antimicrobial peptide expression in the burying beetle. Sci Rep 6, 25409.  DOI  

Joop G, Vilcisnlkas A (2016) Coevolution of parasitic fungi with and their insect hosts. Zoology 119 (4) 350358.  DOI

Klose D, Saunders U, Barth S, Fischer R, Jacobi AM, Nachreiner T (2016) Novel fusion proteins for the antigen-specific staining and elimination of B cell receptor-positive cell populations demonstrated by a tetanus toxoid fragment C (TTC) model antigen. BMC Biotechnol 16 (1) 18.  DOI

Köster N, Schmiermund A, Grubelnig S, Leber J, Ehlicke F, Czermak P, Salzig D (2016) Single-step RNA extraction from in different hydrogels embedded mesenchymal stem cells for quantitative RT-PCR analysis. Tissue Eng Part C 22 (6) 552560.  DOI

Manara A, DalCorso G, Furini A (2016) The role of the atypical kinases ABC1K7 and ABC1K8 in abscisic acid responses. Front Plant Sci 7, 366.  DOI

Manara A, DalCorso G, Guzzo F, Furini A (2016) Loss of the atypical kinases ABC1K7 and ABC1K8 changes the lipid composition of the chloroplast membrane. Plant Cell Physiol 56 (6) 11931204.  DOI

Melcher RLG, Moerschbacher BM (2016) An improved microtiter plate assay to monitor the oxidative burst in monocot and dicot plant cell suspension cultures. Plant Methods 12, 5.  DOI  

Menzel S, Holland T, Boes A, Spiegel H, Fischer R, Buyel JF (2016) Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant-derived malaria vaccine candidates. Front Plant Sci 7, 159.  DOI

Merlin M, Gecchele E, Arcalis E, Remelli S, Brozzetti A, Pezzotti M, Avesani L (2016) Enhanced GAD65 production in plants using the MagnICON transient expression system: optimization of upstream production and downstream processing. Biotechnol J 11 (4) 542–553.  DOI

Mladenov R, Hristodorov D, Cremer C, Gresch G, Grieger E, Schenke L, Klose D, Amoury M, Woitok M, Jost E, Brümmendorf TH, Fendel R, Fischer R, Stein C, Thepen T, Barth S (2016) CD64-directed microtubule associated protein tau kills leukaemic blasts ex vivo. Oncotarget 7 (41) 67166-67174.  DOI

Moghaddam MRB, Tonk M, Schreiber C, Salzig D, Czermak P, Vilcinskas A, Rahnamaeian M (2016) The potential of the Galleria mellonella innate immune system is maximized by the co-presentation of diverse antimicrobial peptides. Biol Chem 397 (9) 939945.  DOI

Moreno JA, Díaz-Gómez J, Nogareda C, Angulo E, Sandmann G, Portero-Otin M, Serrano JCE, Twyman RM, Capell T, Zhu C, Christou P (2016) The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage. Sci Rep 6, 35346.  DOI

Movahed N, Pastore C, Cellini A, Allegro G, Valentini G, Zenoni S, Cavallini E, D'Incà E, Tornielli GB, Filippetti I (2016) The grapevine VviPrx31 peroxidase as a candidate gene involved in anthocyanin degradation in ripening berries under high temperature. J Plant Res 129 (3) 513526.  DOI

Niesen J, Hehmann-Titt G, Woitok M, Fendel R, Barth S, Fischer R, Stein C (2016) A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor. Cancer Lett 374 (2) 229–240.  DOI

Niesen J, Sack M, Seidel M, Fendel R, Barth S, Fischer R, Stein C (2016) SNAP-tag technology: a useful tool to determine affinity constants and other functional parameters of novel antibody fragments. Bioconjug Chem 27 (8) 1931–1941.  DOI

Nogareda C, Moreno JA, Angulo E, Sandmann G, Portero M, Capell T, Zhu C, Christou P (2016) Carotenoid-enriched corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis. Plant Biotechnol J 14 (1) 97–108.  DOI

Pitek AS, Wen AM, Shukla S, Steinmetz NF (2016) The protein corona of plant virus nanoparticles influences their dispersion properties, cellular interactions, and in vivo fates. Small 12 (13) 1758–1769.  DOI 

Pöppel AK, Kahl M, Baumann A, Wiesner J, Gökçen A, Beckert A, Preissner KT, Vilcinskas A, Franta Z (2016) A Jonah-like chymotrypsin from the therapeutic maggot Lucilia sericata plays a role in wound debridement and coagulation. Insect Biochem Mol Biol 70, 138–147.  DOI

Rahnamaeian M, Cytrynska M, Zdybicka-Barabas A, Vilcinskas A (2016) The functional interaction between abaecin and pore-forming peptides indicates a general mechanism of antibacterial potentiation. Peptides 78, 17–23.  DOI

Rasche S, Herwartz D, Schuster F, Fischer R, Schillberg S (2016) More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments. Sci Rep 6, 23371.  DOI

Rossi B, Constantin G (2016) Live imaging of immune responses in experimental models of multiple sclerosis. Front Immunol 7, 506.  DOI

Salzig D, Leber J, Merkewitz K, Lange MC, Köster N, Czermak P (2016) Attachment, growth and detachment of human mesenchymal stem cells in a chemically defined medium. Stem Cells Int 2016, 5246584.  DOI

Schlich K, Beule L, Hund-Rinke K (2016) Single versus repeated applications of CuO and Ag nanomaterials and their effect on soil microflora. Env Poll 215, 322–330.  DOI

Schneider K, Schiermeyer A, Dolls A, Koch N, Herwartz D, Kirchhoff J, Fischer R, Russell SM, Cao Z, Corbin DR, Sastry-Dent L, Ainley WM, Webb SR, Schinkel H, Schillberg S (2016) Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut. Plant Biotechnol J 14 (4) 1151–1160.  DOI

Shiratori H, Feinweber C, Knothe C, Lötsch J, Geisslinger G, Resch E, Parnham M (2016) High-throughput analysis of global DNA methylation using methyl-sensitive digestion. PLOS One 11 (10) e0163184.  DOI

Spohner SC, Czermak P (2016) Heterologous expression of Aspergillus terreus fructosyltransferase in Kluyveromyces lactis. New Biotechnol 33 (4) 473–479.  DOI

Sreekanth KV, Alapan Y, ElKabbash M, Ilker E, Hinczewski M, Gurkan UA, De Luca A, Strangi G (2016) Extreme sensitivity biosensing platform based on hyperbolic metamaterials. Nature Materials 15, 621–627.  DOI

Tafferner N, Barthelmes J, Eberle M, Ferreiros N, Ulshöfer T, Henke M, deBruin N, Mayer CA, Foerch C, Geisslinger G, Parnham MJ, Schiffmann S (2016) Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur J Immunol 46 (3) 570–581.  DOI

Ur Rehman A, Kovacs Z, Ebrahimi M, Quitmann H, Czermak P (2016) Enzymatic production of fructo-oligosaccharides from inexpensive and abundant substrates using a membrane reactor system. Separation Sci Technol 51 (9) 1537–1545.  DOI

Vaas LAI, Witt G, Windshügel B, Bosin A, Serra G, Bruengger A, Winterhalter M, Gribbon P, Levy-Petelinkar CJ, Kohler M (2016) Electronic laboratory notebooks in a public–private partnership. PeerJ Comp Sci 2, e83.  DOI

Vamvaka E, Arcalis E, Ramessar K, Evans A, O’Keefe BR, Shattock RJ, Medina V, Stoger E, Christou P, Capell T (2016) Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV. Plant Biotechnol J 14 (6) 1427–1437.  DOI

Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O’Keefe BR, Christou P, Capell T (2016) Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro. Plant Cell Rep 35 (6) 1309–1319.  DOI

Vamvaka E, Twyman RM, Murad AM, Melnik S, Teh AYH, Arcalis E, Altmann F, Stoger E, Rech E, Ma JKC, Christou P, Capell T (2016) Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12. Plant Biotechnol J 14 (1) 97–108.  DOI

Vasilev N, Boccard J, Lang G, Grömping U, Fischer R, Goepfert S, Rudaz S, Schillberg S (2016) Structured plant metabolomics for the simultaneous exploration of multiple factors. Sci Rep 6, 37390.  DOI

Visser F, Müller B, Rose J, Prüfer D, Noll GA (2016) Forizymes – functionalised artificial forisomes as a platform for the production and immobilisation of single enzymes and multi-enzyme complexes. Sci Rep 6, 30839.  DOI

Wiesner J, Hintz M, Reichenberg A, Ortmann R, Schlitzer M, Ziemann C, Fuhst R, Vilcinskas A, Jomaa H (2016) FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence 7 (6) 718–728.  DOI 

Woitok M, Klose D, Niesen J, Richter W, Abbas M, Stein C, d, Fendel R, Bialon M, Püttmann C, Fischer R, Barth S, Kolberg K (2016) The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F. Cancer Lett 381 (2) 323330.  DOI

Zanga D, Capell T, Zhu C, Christou P, Thangaraj H (2016) Freedom-to-operate analysis of a transgenic multivitamin corn variety. Plant Biotechnol J 14 (5) 1225–1240.  DOI

Zanga D, Capell T, Slafer GA, Christou P, Savin R (2016) A carotenogenic mini-pathway introduced into white corn does not affect development or agronomic performance. Sci Rep 6, 38288.  DOI

Zenoni S, Fasoli M, Guzzo F, Dal Santo S, Amato A, Anesi A, Commisso M, Herderich M, Ceoldo S, Avesani L, Pezzotti M, Tornielli GB (2016) Disclosing the molecular basis of the postharvest life of berry in different grapevine genotypes. Plant Physiol 172 (3) 18211843.  DOI



Abdellatef E, Will T, Koch A, Imani J, Vilcinskas A, Kogel KH (2015) Silencing the expression of the salivary sheath protein causes trans-generational feeding suppression in the aphid Sitobion avenae. Plant Biotechnol J 13 (6) 849–857. 

Anesi A, Stocchero M, Dal Santo S, Commisso M, Zenoni S, Ceoldo S, Tornielli GB, Siebert TE, Herderich M, Pezzotti M, Guzzo F (2015) Towards a scientific interpretation of the terroir concept: plasticity of the grape berry metabolome. BMC Plant Biol 15, 191.

Baumann A, Lehmann R, Beckert A, Vilcinskas A, Franta Z (2015) Selection and evaluation of tissue specific reference genes in Lucilia sericata during an immune challenge. PLOS One 10 (8) e0135093.

Beckert A, Wiesner J, Baumann A, Pöppel AK, Vogel H, Vilcinskas A (2015) Two c-type lysozymes boost the innate immune system of the invasive ladybird Harmonia axyridis. Dev Comp Immunol 49 (2) 303–312.

Beiss V, Spiegel H, Boes A, Kapelski S, Scheuermayer M, Edgue G, Sack M, Fendel R, Reimann A, Schillberg S, Pradel G, Fischer R (2015) Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein. Biotechnol Bioeng 112 (7) 1297–1305.

Boes A, Spiegel H, Edgue G, Kapelski S, Scheuermayer M, Fendel R, Remarque E, Altmann F, Maresch D, Reimann A, Pradel G, Schillberg S, Fischer R (2015) Detailed functional characterization of glycosylated and non-glycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant Biotechnol J 13 (2) 222–234.

Boes A, Spiegel H, Voepel N, Edgue G, Beiss V, Kapelski S, Scheuermayer M, Pradel G, Bolscher JM, Behet MC, Dechering KJ, Hermsen CC, Sauerwein RW, Schillberg S, Reimann A, Fischer R (2015) Analysis of a multi-component multi-stage malaria vaccine candidate – tackling the cocktail challenge. PLOS One 10 (7) e0131456.

Brehm H, Hristodorov D, Pardo A, Mladenov R, Niesen J, Fischer R, Tur MK, Barth S (2015) Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein. Cancer Lett 365 (2) 149–155. 

Bruckman MA, Randolph LN, Gulati NM, Stewart PL, Steinmetz NF (2015) Silica-coated Gd(DOTA)-loaded protein nanoparticles enable magnetic resonance imaging of macrophages. J Mater Chem B 2015 (3) 7503–7510. 

Buntru M, Vogel S, Stoff K, Spiegel H, Schillberg S (2015) A versatile coupled cell-free transcription-translation system based on tobacco BY-2 cell lysates. Biotechnol Bioeng 112 (5) 867–878.

Buyel JF (2015) Controlling the interplay between Agrobacterium tumefaciens and plants during the transient expression of proteins. Bioengineered 6 (4) 242–244.

Buyel JF, Buyel JJ, Hasse C, Fischer R (2015) The impact of Pseudomonas syringae type III effectors on transient protein expression in tobacco. Plant Biol 17 (2) 484492.

Buyel JF, Fischer R (2015) A juice extractor can simplify the downstream processing of plant-derived biopharmaceutical proteins compared to blade-based homogenizers. Process Biochem 5 (5) 859–866.

Buyel JF, Fischer R (2015) Synthetic polymers are more effective than natural flocculants for the clarification of tobacco leaf extracts. J Biotechnol 195, 37–42.

Buyel JF, Gruchow HM, Fischer R (2015) Depth filters containing diatomite achieve more efficient particle retention than filters solely containing cellulose fibers. Front Plant Sci 6, 1134.

Buyel JF, Opdensteinen P, Fischer R (2015) Cellulose-based filter aids increase the capacity of depth filters during the downstream processing of plant-derived biopharmaceutical proteins. Biotechnol J 10 (4) 584–591.

Chang S, Berman J, Sheng Y, Wang Y, Capell T, Shi L, Ni X, Sandmann G, Christou P, Zhu C (2015) Cloning and functional characterization of the maize (Zea mays L.) carotenoid epsilon hydroxylase gene. PLOS One 10 (6) e0128758.

Chocarro C, Lloveras J (2015) The effect of row spacing on alfalfa seed and forage production under irrigated Mediterranean agricultural conditions. Grass Forage Sci 70 (4) 651–660.

Cremer C, Braun H, Mladenov R, Hein L, Cong X, Jost E, Brümmendorf TH, Fischer R, Carloni P, Barth S, Nachreiner T (2015) Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo. Cancer Immunol Immunother 64 (12) 1575–1586.

Cremer C, Vierbuchen T, Hein L, Fischer R, Barth S, Nachreiner T (2015) Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential. J Immunother 38 (3) 85–95.

Dickmeis C, Honickel MM, Fischer R, Commandeur U (2015) Production of hybrid chimeric PVX particles using a combination of TMV and PVX-based expression vectors. Front Bioeng Biotechnol 3, 189.

Doutor C, Ribeiro MC, Fragoso A (2015) Technological Specialization courses in Higher Education: Reflecting on Students’ Motivations and Expectations. ATINER'S Conference Paper Series, EDU2014-1386. 

Epping J, Fricke J, van Deenen N, Niephaus E, Stolze A, Huber C, Eisenreich W, Twyman RM, Prüfer D, Schulze Gronover C (2015) Identification of a rubber transferase activator protein in Taraxacum brevicorniculatum. Nature Plants 1, 15048.

Ferrarini A, Xumerle L, Griggio F, Garonzi M, Cantaloni C, Centomo C, Vargas SM, Descombes P, Marquis J, Collino S, Franceschi C, Garagnani P, Salisbury BA, Harvey JM, Delledonne M (2015) The use of non-variant sites to improve the clinical assessment of whole-genome sequence data. PLOS One 10 (7) e0132180.

Filippetti I, Movahed N, Allegro G, Valentini G, Pastore C, Colucci E, Intrieri C (2015) Effect of post-veraison source limitation on the accumulation of sugar, anthocyanins and seed tannins in Vitis vinifera cv. Sangiovese berries. Aust J Grape Wine Res 21 (1) 90–100.

Fitting J, Blume T, Ten Haaf A, Blau W, Gattenlöhner S, Tur MK, Barth S (2015) Generation of novel internalizing antibody fragments by phage display for immunotoxin-based treatment of acute myeloid leukemia. Monoclon Antib 7 (2) 390–402.

Fritsch L, Fischer R, Schillberg S, Wamback C, Schröper F (2015) Next-generation sequencing is a robust strategy for the detection of zygosity in transgenic maize. Transgenic Res 24 (4) 615–623.

Grumbach C, Czermak P (2015) A new test system for the in-line monitoring of autoclave exhaust treatment: A study of uncertainty. Filtration 15 (4) 213–222. 

Kaiser M, Pereira S, Pohl L, Ketelhut, Kemper B, Gorzelanny, Galla HJ, Moerschbacher BM, Goycoolea FM (2015) Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells. Sci Rep 5, 10048.

Kapelski S, Boes A, Spiegel H, de Almeida M, Klockenbring T, Reimann A, Fischer R,  Barth S, Fendel R (2015) Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody. Malaria J 14, 50.

Kapelski S, de Almeida M, Fischer R, Barth S, Fendel R (2015) Antimalarial activity of granzyme B and its targeted delivery by a granzyme B–scFv fusion protein. Antimicrob Agents Chemother 59 (1) 669–672.

Klinger J, Fischer R, Commandeur U (2015) Comparison of Thermobifida fusca cellulases expressed in Escherichia coli and Nicotiana tabacum indicates advantages of the plant system for the expression of bacterial cellulases. Front Plant Sci 6, 1047.

Knorr E, Schmidtberg H, Arslan D, Bingsohn L, Vilcinskas A (2015) Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum. Biol Lett 11 (12) 20150885.

Hamer SN, Cord-Landwehr S, Biarnés X, Planas A, Waegeman H, Moerschbacher BM, Kolkenbrock S (2015) Enzymatic production of defined chitosan oligomers with a specific pattern of acetylation using a combination of chitin oligosaccharide deacetylases. Sci Rep 5, 8716.

Hristodorov D, Mladenov R, von Felbert V, Huhn M, Fischer R, Barth S, Thepen T (2015) Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies. Monoclon Antib 6 (5) 853–862.

Laibach N, Hillebrand A, Twyman RM, Prüfer D, Schulze Gronover C (2015) Identification of a rubber elongation factor protein in Taraxacum brevicorniculatum which is localized on rubber particles and is important for rubber biosynthesis. Plant J 82 (4) 609–620.

Lampis S, Santi C, Ciurli A, Andreolli M, Vallini G (2015) Promotion of arsenic phytoextraction efficiency in the fern Pteris vittata by the inoculation of As-resistant bacteria: a soil bioremediation perspective. Front Plant Sci 6, 80.

Leufken CM, Moerschbacher BM, Dirks-Hofmeister ME (2015) Dandelion PPO-1/PPO-2 domain-swaps: The C-terminal domain modulates the pH optimum and the linker affects SDS-mediated activation and stability. Biochim Biophys Acta 1854 (2) 178–186.

Ma JKC, Drossard J, Lewis D, Altmann F, Boyle J, Christou P, Cole T, Dale P, van Dolleweerd CJ, Isitt V, Katinger D, Lobedan M, Mertens H, Paul MJ, Rademacher T, Sack M, Hundleby PAC, Stiegler G, Stoger E, Twyman RM, Vcelar B, Fischer R (2015) Regulatory approval and phase-I clinical trial of a monoclonal antibody produced in tobacco. Plant Biotechnol J 13 (8) 1106–1120.

Madhuprakash J, El Gueddari NE, Moerschbacher BM, Podile AR (2015) Catalytic efficiency of chitinase-D on insoluble chitinous substrates was improved by fusing auxiliary domains. PLOS One 10 (1) e0116823.

Madhuprakash J, El Gueddari NE, Moerschbacher BM, Podile AR (2015) Production of bioactive chitosan oligosaccharides using the hypertransglycosylating chitinase-D from Serratia proteamaculans. Bioresource Technol 198, 503–509.

Maskus DJ, Bethke S, Seidel M, Kapelski S, Addai-Mensah O, Boes A, Edgü G, Spiegel H, Reimann A, Fischer R, Barth S, Klockenbring T, Fendel R (2015) Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10. Malar J 14, 276.

Menchicchi B, Fuenzalida JP, Hensel A, Swamy MJ, David L, Rochas C, Goycoolea FM (2015) Biophysical analysis of the molecular interactions between polysaccharides and mucin. Biomacromolecules 16 (3) 924–935.

Mendonça D, Luna S, Bettencourt S, Lopes MS, Monteiro L, Neves JD, Monjardino P, da Câmara Machado A (2015) In vitro propagation of Picconia azorica (Tutin) Knobl. (Oleaceae) an Azorean endangered endemic plant species. Acta Physiol Plant 37, 47.

Milia G, Camiolo S, Avesani L, Porceddu A (2015) The dynamic loss and gain of introns during the evolution of the Brassicaceae. Plant J 82 (6) 915–924.

Mladenov R, Hristodorov D, Thepen T, Cremer C, Hein L, Niesen J, Brehm H, Brümmendorf T, Jost E, Fischer R, Stockmeyer B, Barth S, Stein C (2015) The Fc-alpha receptor is a new immunotherapeutic target antigen for the treatment of myeloid leukaemia. Int J Cancer 137 (11) 27292738.

Niesen J, Brehm H, Stein C, Berges N, Pardo A, Fischer R, Ten Haaf A, Gattenlöhner S, Tur MK, Barth S (2015) In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells. J Cancer Res Clin Oncol 141 (6) 1049–1061.

Niesen J, Stein C, Brehm H, Hehmann-Titt G, Fendel R, Melmer G, Fischer R,  Barth S (2015) Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activitu against different tumor entities. J Cancer Res Clin Oncol 141 (12) 2079–2095.

O'Keeffe C, Champion S, Allsop D (2015) Demonstrating the effect of forensic firearm countermeasures: Bullet characteristics generated due to barrel modifications. Forensic Sci Int 257, 13–19.

Popovic M, Prodanovic R, Ostafe R, Schillberg S, Fischer R, Gavrovic-Jankulovic M (2015) Yeast surface display is a novel tool for the rapid immunological characterization of plant plant-derived food allergens. Immunologic Res 61 (3) 230–239.

Pöppel AK, Vogel H, Wiesner J, Vilcinskas A (2015) Combinatorial activities of antimicrobial peptides expressed in medicinal maggots of the blow fly Lucilia sericata against bacteria.  Antimicrob Agents Chemother 59 (9) 2508–2514. 

Rahnamaeian M, Cytrynska M, Zdybicka-Barabas A, Dobslaff K, Twyman RM, Züchner T, Sadd B, Regoes R, Schmid-Hempel P, Vilcinskas A (2015) Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria. Proc R Soc B 282 (1806) 20150293.

Raven N, Rasche S, Kuehn C, Anderlei T, Klöckner W, Schuster F, Fischer R, Henquet M, Bosch D, Büchs J, Schillberg S (2015) Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200 L orbitally shaken disposable bioreactor. Biotechnol Bioeng 112 (2) 308–321.

Rettcher S, Jungk F, Kühn C, Krause HJ, Nölke G, Commandeur U, Fischer R, Schillberg S, Schröper F (2015) A simple and portable magnetic immunoassay for the rapid detection and sensitive quantitation of plant viruses. Appl Microbiol Biotechnol 81 (18) 3039–3048. 

Sack M, Rademacher T, Spiegel H, Boes A, Hellwig S, Drossard J, Stoger E, Fischer R (2015) From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants. Plant Biotechnol J 13 (8) 1094–1105.

Santos-Carballal B, Aaldering LJ, Ritzefeld M, Pereira S, Sewald N, Moerschbacher BM, Götte M, Goycoolea FM (2015) Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells. Sci Rep 5, 13567.

Schlich K, Hund-Rinke K (2015) The impact of silver nanomaterials on microbial activity differs among five soils with distinct physicochemical properties. Environ Poll 196 (1) 321–330.

Schott M, Klein B, Vilcinskas A (2015) Sniffer bees: Detection of illicit drugs by trained honeybees (Apis mellifera). PLOS One 10 (6) e0128528.

Schubert M, Houdelet M, Kogel KH, Fischer R, Schillberg S, Nölke G (2015) Thanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays). Transgenic Res 24 (5) 885-895.

Shukla S, DiFranco NA, Wen AM, Commandeur U, Steinmetz NF (2015) To target or not to target: active vs. passive tumor homing of filamentous nanoparticles based on Potato virus X. Cel Mol Bioeng 8 (3) 433–444. 

Shukla S, Eber FJ, Nagarajan AS, DiFranco NA, Schmidt N, Wen AM, Eiben S, Twyman RM, Wege C, Steinmetz NF (2015) The impact of aspect ratio on the biodistribution and tumor homing of rigid soft-matter nanoparticles. Adv Healthc Mater 4 (6) 874–882.

Sonnack L, Kampe S, Muth-Köhne E, Erdinger L, Henny N, Hollert H, Schäfers C, Fenske M (2015) Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos. Neurotoxicol Teratol 50, 33–42. 

Spohner S C, Zahn D, Schaum V, Quitmann H, Czermak P (2015)  Recombinant alpha-L-rhamnosidase from Aspergillus terreus in selective trimming of alpha-L-rhamnose from steviol glycosides. J Mol Cat B: Enzymatic 122 (12) 248–254. 

Spiegel H, Boes A, Kastilan R, Kapelski S, Edgue G, Beiss V, Chubodova I, Schillberg S, Reimann A, Fischer R (2015) The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines. Biotechnol J 10 (10) 1651–1659.

Spiegel H, Boes A, Voepel N, Beiss V, Edgue G, Rademacher T, Sack M, Schillberg S, Reimann A, Fischer R (2015) Application of a scalable plant transient gene expression platform for malaria vaccine development. Front Plant Sci 6, 1169.

Spiegel H, Schinkel H, Kastilan R, Dahm P, Boes A, Scheuermayer M, Chudobová I, Maskus D, Fendel R, Schillberg S, Reimann A, Fischer R (2015) Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites. Biotechnol Bioeng 112 (4) 659–667.

Stöveken J, Singh R, Kolkenbrock S, Zakrzewski M, Wibberg D, Eikmeyer FG, Pühler A, Schlüter A, Moerschbacher BM (2015) Successful heterologous expression of a novel chitinase identified by sequence analyses of the metagenome from a chitin-enriched soil sample. J Biotechnol 201, 60–68.

Ten Haaf A, Pscherer S, Fries K, Barth S, Gattenlöhner S, Tur MK (2015) Phage display-based on-slide selection of tumor-specific antibodies on formalin-fixed paraffin-embedded human tissue biopsies. Immunol Lett 166 (2) 65–78.

Tinazzi E, Merlin M, Bason C, Beri R, Zampieri R, Lico C, Bartoloni E, Puccetti A, Lunardi C, Pezzotti M, Avesani L (2015) Plant-derived chimeric virus particles for the diagnosis of primary Sjögren syndrome. Front Plant Sci 6, 1080.

Tonk M, Cabezas-Cruz A, Valdés JJ, Rego RO, Grubhoffer L, Estrada-Peña A, Vilcinskas A, Kotsyfakis M, Rahnamaeian M (2015) Ixodes ricinus defensins attack distantly-related pathogens. Dev Comp Immunol 53 (2) 358–365.

Tonk M, Knorr E, Cabezas-Cruz A, Valdés JJ, Kollewe C, Vilcinskas A (2015) Tribolium castaneum defensins are primarily active against Gram-positive bacteria. J Invertebrate Pathol 132, 208–215. 

van Rijn P, van Bezouwen LS, Fischer R, Boekema EJ, Böker A, Commandeur U (2015) Virus-SiO2 and virus-SiO2-Au hybrid particles with tunable morphology. Part Part Syst Charact 32 (1) 43–47.

Will T, Vilcinskas A (2015) The structural sheath protein of aphids is required for phloem feeding. Insect Biochem Mol Biol 57, 3440.

Zenaro E, Pietronigro E, Bianca VD, Piacentino G, Marongiu L, Budui S, Turano E, Rossi B, Angiari S, Dusi S, Montresor A, Carlucci T, Nanì S, Tosadori G, Calciano L, Catalucci D, Berton G, Bonetti B, Constantin G (2015) Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nature Med 21 (8) 880886. 


Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40 (4) 542–553.

Aragona M, Minio A, Ferrarini A, Valente MT, Bagnaresi P, Orrù L, Tononi P, Zamperin G, Infantino A, Valè G, Cattivelli L, Delledonne M (2014) De novo genome assembly of the soil-borne fungus and tomato pathogen Pyrenochaeta lycopersici. BMC Genomics 15, 313.

Avesani L, Merlin M, Gecchele E, Capaldi S, Brozzetti A, Falorni A, Pezzotti M (2014) Comparative analysis of different biofactories for the production of a major diabetes autoantigen. Transgenic Res 23 (2) 281–291.

Bai C, Rivera SM, Medina V, Alves R, Vilaprinyo E, Sorribas A, Canela R, Capell T, Sandmann G, Christou P, Zhu C (2014) An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation. Plant J 77 (3) 464–475.

Berges N, Hehmann-Titt G, Hristodorov D, Melmer G, Thepen T, Barth S (2014) Human cytolytic fusion proteins: modified versions of human granzyme B and angiogenin have the potential to replace bacterial toxins in targeted therapies against CD64+ diseases. Antibodies 3 (1) 92–115.

Bialon M, Schellenberg L, Herzog N, Kraus S, Jörißen H, Fischer R, Stein C, Nähring J, Barth S, Püttmann C (2014) Cloning murine antibody V-genes with non-degenerate primers and conversion to a recombinant antibody format. Monoclon Antib Immunodiagn Immunother 33 (6) 369–377.

Blohm L, Püttmann C, Holz S, Piechotta G, Albers J, Dammers C, Kleines M, Krüttgen A, Melmer G, Nähring J, Barth S, Nebling E (2014) Rapid detection of different human anti-HCV immunoglobulins on electrical biochips. Antib Technol J 2014 (4) 23–32.

Brehm H, Niesen J, Mladenov R, Stein C, Pardo A, Fey G, Helfrich W, Fischer R, Gattenlöhner S, Barth S (2014) A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues. Cancer Lett 352 (2) 228–235.

Breitenbach J, Bai C, Rivera SM, Canela R, Capell T, Christou P, Zhu C, Sandmann G (2014) A novel carotenoid, 4-keto-alpha-carotene, as an unexpected by-product during genetic engineering of carotenogenesis in rice callus. Phytochemistry 98, 85–91.


Bruckman MA, Randolph LN, Vanmeter A, Hern S, Shoffstall AJ, Taurog RE, Steinmetz NF (2014) Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and spheres in mice. Virology 449, 163–173.


Buntru M, Vogel S, Spiegel H, Schillberg S (2014) Tobacco BY-2 cell-free lysate: an alternative and highly-productive plant-based in vitro translation system. BMC Biotechnol 14 (1) 37.

Buyel JF, Gruchow HM, Boes A, Fischer R (2014) Rational design of a host cell protein heat precipitation step can simplify the subsequent purification of recombinant proteins from tobacco. Biochem Eng J 88, 162–170.

Buyel JF, Fischer R (2014) Characterization of complex systems using the design of experiments approach: transient protein expression in tobacco as a case study. J Vis Exp 83, e51216.

Buyel JF, Fischer R (2014) Downstream processing of biopharmaceutical proteins produced in plants: The pros and cons of flocculants. Bioengineered 5 (2) 138–142.

Buyel JF, Fischer R (2014) Flocculation increases the efficacy of depth filtration during the downstream processing of recombinant pharmaceutical proteins produced in tobacco. Plant Biotechnol J 12 (2) 240–252.

Buyel JF, Fischer R (2014) Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants. Biotechnol J 9 (4) 566–577.

Buyel JF, Fischer R (2014) Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves. Biotechnol J 9 (3) 415–425.

Cavallini E, Zenoni S, Finezzo L, Guzzo F, Zamboni A, Avesani L, Tornielli GB (2014) Functional diversification of grapevine MYB5a and MYB5b in the control of flavonoid biosynthesis in a petunia anthocyanin regulatory mutant. Plant Cell Physiol 55 (3) 517–534.

Company N, Nadal A, La Paz JL, Martínez S, Rasche S, Schillberg S, Montesinos E, Pla M (2014) The production of recombinant cationic alpha-helical antimicrobial peptides in plant cells induces the formation of protein bodies derived from the endoplasmic reticulum. Plant Biotechnol J 12 (1) 81–92.

Dickmeis C, Fischer R, Commandeur U (2014) Potato virus X-based expression vectors are stabilized for long-term production of proteins and larger inserts. Biotechnol J 9 (11) 1369–1379.

Dirks-Hofmeister ME, Singh R, Leufken CM, Inlow JK, Moerschbacher BM (2014) Structural diversity in the dandelion (Taraxacum officinale) polyphenol oxidase family results in different responses to model substrates. PLoS One 9 (6) e99759.

Freitak D, Schmidtberg H, Dickel F, Lochnit G, Vogel H, Vilcinskas A (2014) The maternal transfer of bacteria can mediate trans-generational immune priming in insects. Virulence 5 (4) 547–554.

Fuenzalida JP, Weikert T, Hoffmann S, Vila-Sanjurjo C, Moerschbacher BM, Goycoolea FM, Kolkenbrock S (2014) Affinity protein-based FRET tools for cellular tracking of chitosan nanoparticles and determination of the polymer degree of acetylation. Biomacromolecules 15 (7) 2532–2539.

Gasch T, Vilcinskas A (2014) The chemical defense in larvae of the earwig Forficula auricularia. J Insect Physiol 67, 1–8.

Garvey M, Klinger J, Klose H, Fischer R, Commandeur U (2014) Expression of recombinant cellulase Cel5A from Trichoderma reesei in tobacco plants. J Vis Exp 88, e51711.

Gecchele E, Schillberg S, Merlin M, Pezzotti M, Avesani L (2014) A downstream process allowing the efficient isolation of a recombinant amphiphilic protein from tobacco leaves. J Chromatogr B 960, 34–42.

Gökçen A, Vilcinskas A, Wiesner J (2014) Biofilm-degrading enzymes from Lysobacter gummosus. Virulence 5 (3) 378–387.

Groscurth S, Müller B, Visser F, Blob B, Menzel M, Rüping BA, Twyman RM, Prüfer D, Noll G (2014) Uncertain role of MtSEO-F3 in assembly of Medicago truncatula forisomes. Plant Signal Behav 9, e29581.

Häkkinen ST, Raven N, Henquet M, Laukkanen ML, Anderlei T, Pitkänen JP, Twyman RM, Bosch D, Oksman-Caldentey KM, Schillberg S, Ritala A (2014) Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody. Biotechnol Bioeng 111 (2) 336–346.

Havenith H, Raven N, Di Fiore S, Fischer R, Schillberg S (2014) Image-based analysis of cell-specific productivity for plant cell suspension cultures. Plant Cell Tiss Org Cult 117 (3) 393–399.

Honke N, Ohl K, Wiener A, Bierwagen J, Peitz J, Di Fiore S, Fischer R, Wagner N, Wüller S, Tenbrock K (2014) The p38-mediated rapid down-regulation of cell surface gp130 expression impairs interleukin-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients. Arthritis Rheumatol 66 (2) 470–478.

Hofbauer A, Peters J, Arcalis E, Rademacher T, Lampel J, Eudes F, Vitale A, Stoger E (2014) The induction of recombinant protein bodies in different subcellular compartments reveals a cryptic plastid-targeting signal in the 27-kDa gamma-zein sequence. Frontiers Bioeng Biotechnol 2, 67.

Hristodorov D, Mladenov R, Brehm H, Fischer R, Barth S, Thepen T (2014) Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody: A potential strategy to enhance anti-TNF therapy. Monoclon Antib 6 (5) 1283–1289.

Hristodorov D, Nordlohne J, Mladenov R, Huhn M, Fischer R, Thepen T, Barth S (2014) Human microtubule-associated protein tau mediates targeted killing of CD30+ lymphoma cells in vitro and inhibits tumour growth in vivo. Br J Haematol 164 (2) 251–257.

Hund-Rinke K, Schlich K (2014) The potential benefits and limitations of different test procedures to determine the effects of Ag nanomaterials and AgNO3 on microbial nitrogen transformation in soil. Env Sci Eur 26 (1) 28.

Ibl V, Kapusi E, Arcalis E, Kawagoe Y, Stoger E (2014) Fusion, rupture, and degeneration: the fate of in vivo-labelled PSVs in developing barley endosperm. J Exp Bot 65 (12) 32493261.

Ibl V, Stöger E (2014) Live cell imaging during germination reveals dynamic tubular structures derived from protein storage vacuoles of barley aleurone cells. Plants 3 (3) 442–457.

Jansen F, Gillessen B, Mueller F, Commandeur U, Fischer R, Kreuzaler F (2014) Metabolic engineering for p-coumaryl alcohol production in Escherichia coli by introducing an artificial phenylpropanoid pathway. Biotechnol Appl Biochem 61 (6) 646–654.

Juodeikiene G, Vidmantiene D, Basinskiene L, Cernauskas D, Klupsaite D, Petrauskas A, Bartkiene E, de Koe WJ (2014) Recent advances in the rapid acoustic screening of deoxynivalenol in wheat grains. World Mycotox J 7 (4) 517–525.

Kapelski S, Klockenbring T, Fischer R, Barth S, Fendel R (2014) Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum. J Leukoc Biol 96 (6) 1131–1142.

Livi CM, Blanzieri E (2014) Protein-specific prediction of mRNA binding using RNA sequences, binding motifs and predicted secondary structures. BMC Bioinformatics 15 (1) 123.

Lovato A, Faoro F, Gambino G, Maffi D, Bracale M, Polverari A, Santi L (2014) Construction of a synthetic infectious cDNA clone of Grapevine Algerian latent virus (GALV-Nf) and its biological activity in Nicotiana benthamiana and grapevine plants. Virology J 11 (1) 186. 

Manara A, Dalcorso G, Leister D, Jahns P, Baldan B, Furini A (2014) AtSIA1 and AtOSA1: two Abc1 proteins involved in oxidative stress responses and iron distribution within chloroplasts. New Phytol 201 (2) 452–465.


Mandal MK, Fischer R, Schillberg S, Schiermeyer A (2014) Inhibition of protease activity by antisense RNA improves recombinant protein production in Nicotiana tabacum cv Bright Yellow 2 (BY-2) suspension cells. Biotechnol J 9 (8) 1065–1073.

Masani MY, Noll GA, Parveez GK, Sambanthamurthi R, Prüfer D (2014) Efficient transformation of oil palm protoplasts by PEG-mediated transfection and DNA microinjection. PLoS One 9 (5) e96831.

Menchicchi B, Fuenzalida JP, Bobbili KB, Hensel A, Swamy MJ, Goycoolea FM (2014) The structure of chitosan determines its interactions with mucin. Biomacromolecules 15 (10) 3550–3558.   

Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D (2014) The seco-iridoid pathway from Catharanthus roseus. Nature Commun 5, 3606.

Mukherjee K, Vilcinskas A (2014) Development and immunity-related microRNAs of the lepidopteran model host Galleria mellonella. BMC Genomics 15 (1) 705.

Müller B, Groscurth S, Menzel M, Rüping BA, Twyman RM, Prüfer D, Noll GA (2014) Molecular and ultrastructural analysis of forisome subunits reveals the principles of forisome assembly. Ann Bot 113 (7) 1121–1137.

Nölke G, Houdelet M, Kreuzaler F, Peterhänsel C, Schillberg S (2014) The expression of a recombinant glycolate dehydrogenase polyprotein in potato (Solanum tuberosum) plastids strongly enhances photosynthesis and tuber yield. Plant Biotechnol J 12 (6) 734–742.

Ostafe R, Prodanovic R, Nazor J, Fischer R (2014) Ultra-high-throughput screening method for the directed evolution of glucose oxidase. Chem Biol 21 (3) 414–421.

Ostafe R, Prodanovic R, Ung WL, Weitz DA, Fischer R (2014) A high-throughput cellulase screening system based on droplet microfluidics. Biomicrofluidics 8, 041102.

Palumbo MC, Zenoni S, Fasoli M, Massonnet M, Farina L, Castiglione F, Pezzotti M, Paci P (2014) Integrated network analysis identifies fight-club nodes as a class of hubs encompassing key putative switch genes that induce major transcriptome reprogramming during grapevine development. Plant Cell 26 (12) 4617–4635.

Peremarti A, Marè C, Aprile A, Roncaglia E, Cattivelli L, Villegas D, Royo C (2014) Transcriptomic and proteomic analyses of a pale-green durum wheat mutant shows variations in photosystem components and metabolic deficiencies under drought stress. BMC Genomics 15, 125.

Peuscher A, Gassler N, Schneider U, Thom P, Rasche S, Spiegel H, Schillberg S (2014) An immunohistochemical assay on human tissue using a human primary antibody. J Immunoassay Immunochem 35 (3) 322–334.

Pilati S, Brazzale D, Guella G, Milli A, Ruberti C, Biasioli F, Zottini M, Moser C (2014) The onset of grapevine berry ripening is characterized by ROS accumulation and lipoxygenase-mediated membrane peroxidation in the skin. BMC Plant Biol 14, 87.

Pöppel AK, Koch A, Kogel KH, Vogel H, Kollewe C, Wiesner J, Vilcinskas A (2014) Lucimycin, an antifungal peptide from the therapeutic maggot of the common green bottle fly Lucilia sericata. Biol Chem 395 (6) 649–656.

Post J, Eisenreich W, Huber C, Twyman RM, Prüfer D, Schulze Gronover C (2014) Establishment of an ex vivo laticifer cell suspension culture from Taraxacum brevicorniculatum as a production system for cis-isoprene. J Mol Cat B 103, 85–93.


Ritala A, Dong L, Imseng N, Seppänen-Laakso T, Vasilev N, van der Krol S, Rischer H, Maaheimo H, Virkki A, Brändli J, Schillberg S, Eibl R, Bouwmeester H, Oksman-Caldentey KM (2014) Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway. J Biotechnol 176, 20–28.

Rocha S, Monjardino P, Mendonça D, da Câmara Machado A, Fernandes R, Sampaio P, Salema R (2014) Lignification of developing maize (Zea mays L.) endosperm transfer cells and starchy endosperm cells. Frontiers Plant Sci 5, 102.

Schiffer S, Rosinke R, Jost E, Hehmann-Titt G, Huhn M, Melmer G, Barth S, Thepen T (2014) Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins. Int J Cancer 135 (6) 1497–1508.

Schiller V, Zhang X, Hecker M, Schäfers C, Fischer R, Fenske M (2014) Species-specific considerations in using the fish embryo test as an alternative to identify endocrine disruption. Aquat Toxicol 155 (10) 62–72.

Schramm OG, López-Cortés X, Santos LS, Laurie VF, González Nilo FD, Krolik M, Fischer R, Di Fiore S (2014) pH-dependent nano-capturing of tartaric acid using dendrimers. Soft Matter 10 (4) 600–608.

Shukla S, Dickmeis C, Nagarajan AS, Fischer R, Commandeur U, Steinmetz NF (2014) Molecular farming of fluorescent virus-based nanoparticles for optical imaging in plants, human cells and mouse models. Biomaterials Sci 2 (5) 784–797.

Shukla S, Wen AM, Ayat NR, Commandeur U, Gopalkrishnan R, Broome AM, Lozada KW, Keri RA, Steinmetz NF (2014) Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine (Lond) 9 (2) 221–235.

Vasilev N, Schmitz C, Dong L, Ritala A, Imseng N, Häkkinen ST, van der Krol S, Eibl R, Oksman-Caldentey K-M, Bouwmeester H, Fischer R, Schillberg S (2014) Comparison of plant-based expression platforms for the heterologous production of geraniol. Plant Cell Tissue Org Cult 117 (3) 373–380.

Vasilev N, Schmitz C, Fischer R, Grömping U, Schillberg S (2014) Assessment of cultivation factors effects that affect biomass and geraniol production in transgenic tobacco cell suspension cultures. PLOS One 9 (8) e104620.

Voepel N, Boes A, Edgue G, Beiss V, Kapelski S, Reimann A, Schillberg S, Pradel G, Fendel R, Scheuermayer M, Spiegel H, Fischer R (2014) Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high-level in plants. Biotechnol J 9 (11) 1435–1445.


Vogel H, Badapanda C, Knorr E, Vilcinskas A (2014) RNA-sequencing analysis reveals abundant developmental stage-specific and immunity-related genes in the pollen beetle Meligethes aeneus. Insect Mol Biol 23 (1) 98–112.

Wen AM, Steinmetz NF (2014) The aspect ratio of nanoparticle assemblies and the spatial arrangement of ligands can be optimized to enhance the targeting of cancer cells. Adv Healthcare Materials 3 (11) 1739–1744.

Winckler S, Krueger R, Schnitzler T, Zang W, Fischer R, Biselli M (2014) A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach. Bioprocess Biosyst Eng 37 (5) 901–912.

Zhu C, Yang Q, Ni X, Bai C, Sheng Y, Shi L, Capell T, Sandmann G, Christou P (2014) Cloning and functional analysis of the promoters that upregulate carotenogenic gene expression during flower development in Gentiana lutea. Physiol Plant 150 (4) 493–504.

Zielonka S, Ernst AM, Hawat S, Twyman RM, Prüfer D, Noll GA (2014) Characterization of five subgroups of the sieve element occlusion gene family in Glycine max reveals genes encoding non-forisome P-proteins, forisomes and forisome tails. Plant Mol Biol 86 (1–2) 51–67.





Altincicek B, Elashry A, Guz N, Grundler FM, Vilcinskas A, Dehne HW (2013) Next-generation sequencing-based transcriptome analysis of septic-injury responsive genes in the beetle Tribolium castaneum. PLoS One 8 (1) e52004.


Angiari S, Rossi B, Piccio L, Zinselmeyer BH, Budui S, Zenaro E, Della Bianca V, Bach SD, Scarpini E, Bolomini-Vittori M, Piacentino G, Dusi S, Laudanna C, Cross AH, Miller MJ, Constantin G (2013) Regulatory T cells suppress the late phase of  the immune response in lymph nodes through P-selectin glycoprotein ligand-1. J Immunol. 191 (11) 5489–5500.


Arcalis E, Stadlmann J, Rademacher T, Marcel S, Sack M, Altmann F, Stoger E (2013) Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins. Plant Mol Biol 83 (1–2) 105–117.

Baptista C, Lopes MS, Tavares AC, Rojer H, Kappmeyer L, Mendonça D, da Câmara Machado A (2013) Diagnosis of Theileria equi infections in horses in the Azores using cELISA and nested PCR. Ticks Tick Borne Dis 4 (3) 242–245.

Bebrone C, Bogaerts P, Delbrück H, Bennink S, Kupper MB, Rezende de Castro R, Glupczynski Y, Hoffmann KM (2013) GES-18, a new carbapenem-hydrolyzing GES-Type ß-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrob Agents Chemother 57 (1) 396–401.


Biau A, Santiveri F, Lloveras J (2013) Stover management and nitrogen fertilization effects on corn production. Agron J 105 (5) 1264–1270. 

Blazic M, Kovacevic G, Prodanovic O, Ostafe R, Gavrovic-Jankulovic M, Fischer R, Prodanovic R (2013) Yeast surface display for the expression, purification and characterization of wild-type and B11 mutant glucose oxidases. Protein Expr Purif 89 (2) 175–180.


Buyel JF, Fischer R (2013) Processing heterogeneous biomass: overcoming the hurdles in model building. Bioengineered 4 (1) 21–24.

Buyel JF, Kaever T, Buyel JJ, Fischer R (2013) Predictive models for the accumulation of a fluorescent marker protein in tobacco leaves according to the promoter/5'UTR combination. Biotechnol Bioeng 110 (2) 471–482.

Buyel JF, Woo JA, Cramer SM, Fischer R (2013) The use of quantitative structure-activity relationship models to develop optimized processes for the removal of tobacco host cell proteins during biopharmaceutical production. J Chromatogr A 1322, 18–28.


Chen F, Fasoli M, Tornielli GB, Dal Santo S, Pezzotti M, Zhang L, Cai B, Cheng ZM (2013) The evolutionary history and diverse physiological roles of the grapevine calcium-dependent protein kinase gene family. PLoS One 8 (12) e80818.


Da Silva C, Zamperin G, Ferrarini A, Minio A, Dal Molin A, Venturini L, Buson G, Tononi P, Avanzato C, Zago E, Boido E, Dellacassa E, Gaggero C, Pezzotti M, Carrau F, Delledonne M (2013) The high polyphenol content of grapevine cultivar Tannat berries is conferred primarily by genes that are not shared with the reference genome. Plant Cell 25 (12) 47774788.


Dal Santo S, Tornielli G, Zenoni S, Fasoli M, Farina L, Anesi A, Guzzo F, Delledonne M, Pezzotti M (2013) The plasticity of the grapevine berry transcriptome. Genome Biol 14, r54.

Dal Santo S, Vannozzi A, Tornielli GB, Fasoli M, Venturini L, Pezzotti M, Zenoni S (2013) Genome-wide analysis of the expansin gene superfamily reveals grapevine-specific structural and functional characteristics. PLOS One 8 (4) e62206.

Daschner de Tercero M, Bruns M, González Martínez I, Türk M, Fehrenbacher U, Jennewein S, Barner L (2013) Continuous hydrothermal synthesis of in situ functionalized iron oxide nanoparticles: A general strategy to produce metal oxide nanoparticles With clickable anchors. Particle Syst Char 30 (3) 229–234.


Dashevskaya S,  Horn R,  Chudobova I,  Schillberg S,  Vélez SMV,  Capell T,  Christou C (2013) Abscisic acid and the herbicide safener cyprosulfamide cooperatively enhance abiotic stress tolerance in rice. Mol Breeding 32 (2) 463–484.


Díaz C, Laurie VF, Molina AM, Bücking M, Fischer R (2013) Characterization of selected organic and mineral components of qvevri wines. Am J Enol Vitic 64, 532–537.


Díaz C, Molina AM, Nähring J, Fischer R (2013) Characterization and dynamic behavior of wild yeast during spontaneous wine fermentation in steel tanks and amphorae. Biomed Res Int 2013, 540465.

Dirks-Hofmeister ME, Kolkenbrock S, Moerschbacher BM (2013) Parameters that enhance the bacterial expression of active plant polyphenol oxidases. PLoS One 8 (10) e77291.

Fabene PF, Laudanna C, Constantin G (2013) Leukocyte trafficking mechanisms in epilepsy. Mol Immunol 55 (1) 100–104.

Farré G, Maiam Rivera S, Alves R, Vilaprinyo E, Sorribas A, Canela R, Naqvi S, Sandmann G, Capell T, Zhu C, Christou P (2013) Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that can be addressed by multigene engineering. Plant J 75 (3) 441–455.


Feller T, Thom P, Koch N, Spiegel H, Addai-Mensah O, Fischer R, Reimann A, Pradel G, Fendel R, Schillberg S, Scheuermayer M, Schinkel H (2013) Plant-based production of recombinant Plasmodium surface protein pf38 and evaluation of its potential as a vaccine candidate. PLoS One 8 (11) e79920.


Fricke J, Hillebrand A, Twyman RM, Prüfer D, Gronover CS (2013) Abscisic acid-dependent regulation of small rubber particle protein gene expression in Taraxacum brevicorniculatum is mediated by TbbZIP1.1. Plant Cell Physiol 54 (4) 448–464.

Fragoso A (2013) The transition of mature students to higher education: challenging traditional concepts? Stud Edu Adults 45 (1) 67–81.

Gasch T, Schott M, Wehrenfennig C, Düring RA, Vilcinskas A (2013) Multifunctional weaponry: the chemical defenses of earwigs. J Insect Physiol 59 (12) 1186–1193.


Gökçen A, Vilcinskas A, Wiesner J (2013) Methods to identify enzymes that degrade the main extracellular polysaccharide component of Staphylococcus epidermidis biofilms. Virulence 4 (3) 260–270.

Gonçalves S, Gomes D, Costa P, Romano A (2013) The phenolic content and antioxidant activity of infusions from Mediterranean medicinal plants. Ind Crop Prod 43, 465–471.


Grünwald S, Stellzig J, Adam IV, Weber K, Binger S, Boll M, Knorr E, Twyman RM, Vilcinskas A, Wenzel U (2013) Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes. Genes Nutr 8 (5) 439–448.

Heinig U, Scholz S, Jennewein S (2013) Getting to the bottom of Taxol biosynthesis by fungi. Fung Div 60 (1) 161–170.

Holland T, Blessing D, Hellwig S, Sack M (2013) The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology. Biotechnol J 8 (10) 1231–1240.

Horn R, Chudobova I, Hänsel U, Herwartz D, Koskull-Döring PV, Schillberg S (2013) Simultaneous treatment with tebuconazole and abscisic acid induces drought and salinity stress tolerance in Arabidopsis thaliana by maintaining key plastid protein levels. J Proteome Res 12 (3) 1266–1281.


Hristodorov D, Mladenov R, Pardo A, Pham AT, Huhn M, Fischer R, Thepen T, Barth S (2013) Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo. Br J Cancer 109 (6) 1570–1578.


Hussain AF, Tur MK, Barth S (2013) An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing avß3 integrin. Nucleic Acid Ther 23 (3) 203–212.


Jekat SB, Ernst AM, von Bohl A, Zielonka S, Twyman RM, Noll GA, Prüfer D (2013) P-proteins in Arabidopsis are heteromeric structures involved in rapid sieve tube sealing. Frontiers Plant Sci 4, 225.

Jiang L, Yu X, Qi X, Yu Q, Deng S, Bai B, Li N, Zhang A, Zhu C, Liu B, Pang J (2013) Multigene engineering of starch biosynthesis in maize endosperm increases the total starch content and the proportion of amylose. Transgenic Res 22 (6) 1133–1142.


Klose H, Günl M, Usadel B, Fischer R, Commandeur U (2013) Ethanol-inducible expression of a mesophilic cellulase avoids adverse effects on plant development. Biotechnol Biofuels 6 (1) 53.


Lee KL, Hubbard LC, Hern S, Yildiz I, Gratzl M, Steinmetz NF (2013) Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct. Biomaterials Sci 1 (6) 581–588 


Martins N, Gonçalves S, Andrade PB, Valentão P, Romano A (2013) Changes on organic acid secretion and accumulation in Plantago almogravensis Franco and Plantago algarbiensis Samp. under aluminum stress. Plant Sci 198 (1) 1–6.


Martins N, Gonçalves S, Romano A (2013) Aluminum inhibits root growth and induces hydrogen peroxide accumulation in Plantago algarbiensis and P. almogravensis seedlings. Protoplasma 250 (6) 1295–1302.

Martins N, Gonçalves S, Romano A (2013) Metabolism and aluminum accumulation in Plantago almogravensis and P. algarbiensis in response to low pH and aluminum stress. Biol Plant 57 (2) 325–331.


Martins N, Osório ML, Gonçalves S, Osório J, Romano A (2013) Differences in Al tolerance between Plantago algarbiensis and P. almogravensis reflect their ability to respond to oxidative stress. Biometals 26 (3) 427–437.

Masani MY, Noll G, Parveez GK, Sambanthamurthi R, Prüfer D (2013) Regeneration of viable oil palm plants from protoplasts by optimizing media components, growth regulators and cultivation procedures. Plant Sci 210, 118–127.


Monjardino P, Rocha S, Tavares AC, Fernandes R, Sampaio P, Salema R, da Câmara Machado A (2013) Development of flange and reticulate wall ingrowths in maize (Zea mays L.) endosperm transfer cells. Protoplasma 250 (2) 495–503.


Mukherjee K, Hain T, Fischer R, Chakraborty T, Vilcinskas A (2013) Brain infection and activation of neuronal repair mechanisms by the human pathogen Listeria monocytogenes in the lepidopteran model host Galleria mellonella. Virulence 4 (4) 324–332.


Munt O, Prüfer D, Schulze Gronover C (2013) A novel C-S lyase from the latex-producing plant Taraxacum brevicorniculatum displays alanine aminotransferase and L-cystine lyase activity. J Plant Physiol 170 (1) 33–40.

Muth-Köhne E, Wichmann A, Delov V, Fenske M (2012) The classification of motor neuron defects in the zebrafish embryo toxicity test (ZFET) as an animal alternative approach to assess developmental neurotoxicity. Neurotoxicol Teratol 34, 413–424.

Nausch H, Mikschofsky H, Koslowski R, Steinmann A, Meyer U, Broer I, Huckauf J (2013) An endoplasmic reticulum (ER)-directed fusion protein comprising a bacterial subtilisin domain and the human cytokine interleukin 6 is efficiently cleaved in planta. Afr J Biotechnol 12 (3) 311–319.

Osório ML, Gonçalves S, Coelho N, Osório J, Romano A (2013) Morphological, physiological and oxidative stress markers during acclimatization and field transfer of micropropagated Tuberaria major plants. Plant Cell Tiss Org Cult 115 (1) 85–97.

Ostafe R, Prodanovic R, Commandeur U, Fischer R (2013) Flow cytometry-based ultra-high-throughput screening assay for cellulase activity. Anal Biochem 435 (1) 93–98.

Pastore C, Zenoni S, Fasoli M, Pezzotti M, Tornielli GB, Filippetti I (2013) Selective defoliation affects plant growth, fruit transcriptional ripening program and flavonoid metabolism in grapevine. BMC Plant Biol 13, 30. 

Peters J, Sabalza M, Ramessar K, Christou P, Capell T, Stöger E, Arcalís E (2013) Efficient recovery of recombinant proteins from cereal endosperm is affected by interaction with endogenous storage proteins. Biotechnol J 8 (10) 1203–1212.


Porceddu A, Zenoni S, Camiolo S (2013) The signatures of selection for translational accuracy in plant genes. Genome Biol Evol 5 (6) 1117–1126.


Sanahuja G, Farré G, Bassie L, Zhu C, Christou P, Capell T (2013) Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation during endosperm development. Biotechnol J 8 (10) 1221–1230.

Shahryari F, Safarnejad MR, Shams-Bakhsh M, Schillberg S, Nölke G (2013) Generation and expression in plants of a single-chain variable fragment antibody against the immunodominant membrane protein of Candidatus Phytoplasma aurantifolia. J Microbiol Biotechnol 23 (8) 1047–1054.


Schiffer S, Hansen HP, Hehmann-Titt G, Huhn M, Fischer R, Barth S, Thepen T (2013) Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model. Blood Cancer J 3, e106.

Schiffer S, Letzian S, Jost E, Mladenov R, Hristodorov D, Huhn M, Fischer R, Barth S, Thepen T (2013) Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. Cancer Lett 341 (2) 178–185.


Schlich K, Klawonn T, Terytze K, Hund-Rinke K (2013) Effects of silver nanoparticles and silver nitrate in the earthworm reproduction test. Environ Toxicol Chem 32 (1) 181–188.


Schiller V, Wichmann A, Kriehuber R, Schäfers C, Fischer R, Fenske M (2013) Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption. Reprod Toxicol 42, 210–223.


Schmidtberg H, Röhrich C, Vogel H, Vilcinskas A (2013) A switch from constitutive chemical defence to inducible innate immune responses in the invasive ladybird Harmonia axyridis. Biol Lett 9 (3) 20130006.


Schott M, Wehrenfennig C, Gasch T, Düring RA, Vilcinskas A (2013) A portable gas chromatograph with simultaneous detection by mass spectrometry and electroantennography for the highly sensitive in situ measurement of volatiles. Anal Bioanal Chem 405 (23) 7457–7467.


Shukla S, Ablack AL, Wen AM, Lee KL, Lewis JD, Steinmetz NF (2013) Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X. Mol Pharm 10 (1) 33–42.


Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G (2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13 (1) 29–41.


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Taghavian O, Spiegel H, Hauck R, Hafez HM, Fischer R, Schillberg S (2013) Protective oral vaccination against Infectious bursal disease virus using the major viral antigenic protein VP2 produced in Pichia pastoris. PLoS One 8 (12) e83210.

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Vilcinskas A (2011) Insects emerge as valuable model hosts to explore virulence. Virulence 2 (5) 376–378.

Zenoni S, D'Agostino N, Tornielli GB, Quattrocchio F, Chiusano ML, Koes R, Zethof J, Guzzo F, Delledonne M, Frusciante L, Gerats T, Pezzotti M (2011) Revealing impaired pathways in the an11 mutant by high-throughput characterization of Petunia axillaris and Petunia inflata transcriptomes. Plant J 68 (1) 11–27.

Zenoni S, Fasoli M, Tornielli GB, Dal Santo S, Sanson A, de Groot P, Sordo S, Citterio S, Monti F, Pezzotti M (2011) Overexpression of PhEXPA1 increases cell size, modifies cell wall polymer composition and affects the timing of axillary meristem development in Petunia hybrida. New Phytol 191 (3) 662–677.

Zhou MB, Liu XM, Tang DQ (2011) Transposable elements in Phyllostachys pubescens (Poaceae) genome survey sequences and the full-length cDNA sequences, and their association with simple-sequence repeats. Genet Mol Res 10 (4) 3026–3037.


Zhou MB, Zhong H, Tang DQ (2011) Isolation and characterization of seventy-nine full-length mariner-like transposase genes in the Bambusoideae subfamily. J Plant Res 124 (5) 607–617.

Zhou MB, Yang P, Gao PJ, Tang DQ (2011) Identification of differentially expressed sequence tags in rapidly elongating Phyllostachys pubescens internodes by suppressive subtractive hybridization. Plant Mol Biol Rep 29 (1) 224–231


Arcalis E, Stadlmann J, Marcel S, Drakakaki G, Winter V, Rodriguez J, Fischer R, Altmann F, Stoger E (2010) The changing fate of a secretory glycoprotein in developing maize endosperm. Plant Physiol 153 (2) 693–702.

Avesani L, Vitale A, Pedrazzini E, Devirgilio M, Pompa A, Barbante A, Gecchele E, Dominici P, Morandini F, Brozzetti A, Falorni A, Pezzotti M (2010) Recombinant human GAD65 accumulates to high levels in transgenic tobacco plants when expressed as an enzymatically inactive mutant. Plant Biotechnol J 8 (8) 862–872.

Ballottari M, Girardon J, Betterle N, Morosinotto T, Bassi R (2010) Identification of the chromophores involved in aggregation-dependent energy quenching of the monomeric photosystem II antenna protein Lhcb5. J Biol Chem 285 (36) 28309–28321.

Di Matteo A, Sacco A, Anacleria M, Pezzotti M, Delledonne M, Ferrarini A, Frusciante L, Barone A (2010) The ascorbic acid content of tomato fruits is associated with the expression of genes involved in pectin degradation. BMC Plant Biol 10, 163.

Fitting J, Killian D, Junghanss C, Willenbrock S, Murua Escobar H, Lange S, Nolte I, Barth S, Tur MK (2010) Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology. Vet Comp Oncol 9 (3) 183–195.

Gattenlöhner S, Jörissen H, Huhn M, Vincent A, Beeson D, Tzartos S, Mamalaki A, Etschmann B, Muller-Hermelink HK, Koscielniak E, Barth S, Marx A (2010) A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model. J Biomed Biotechnol 2010, 187621.

Gómez P, Sempere RN, Amari K, Gómez-Aix C, Aranda MA (2010) Epidemics of Tomato torrado virus, Pepino mosaic virus and Tomato chlorosis virus in tomato crops: do mixed infections contribute to torrado disease epidemiology? Ann Appl Biol 156 (3) 401–410.

Gonzalez VM, Rodriguez-Moreno L, Centeno E, Benjak A, Garcia-Mas J, Puigdomenech P, Aranda MA (2010) Genome-wide BAC-end sequencing of Cucumis melo using two BAC libraries. BMC Genomics 11, 618.

Guo R, Shi L, Ding X, Hu Y, Tian S, Yan D, Shao S, Gao Y, Liu R, Yang Y (2010) Effects of saline and alkaline stress on germination, seedling growth, and ion balance in wheat. Agron J 102 (4) 1252–1260.

Hund-Rinke K, Schlich K, Wenzel A (2010) TiO2  nanoparticles – Relationship between dispersion preparation method and ecotoxicity in the algal growth test. Umel Schad Forsch 22 (5) 517–528.

Kampmeier F, Niesen J, Koers A, Ribbert M, Brecht A, Fischer R, Kiessling F, Barth S, Thepen T (2010) Rapid optical imaging of EGF receptor expression with a single-chain antibody SNAP-tag fusion protein. Eur J Nucl Med Mol Imaging 37 (10) 1926–1934.

Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C (2010) Cloning and functional characterization of the maize carotenoid isomerase and beta-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Res 19 (6) 1053–1068.

Mandal MK, Fischer R, Schillberg S, Schiermeyer A (2010) Biochemical properties of the matrix metalloproteinase NtMMP1 from Nicotiana tabacum cv. BY-2 suspension cells. Planta 232 (4) 899–910.

Muller B, Noll GA, Ernst AM, Ruping B, Groscurth S, Twyman RM, Kawchuk LM, Prufer D (2010) Recombinant artificial forisomes provide ample quantities of smart biomaterials for use in technical devices. Appl Microbiol Biotechnol 88 (3) 689–698.

Peremarti A, Bassie L, Yuan D, Pelacho A, Christou P, Capell T (2010) Transcriptional regulation of the rice arginine decarboxylase (Adc1) and S-adenosylmethionine decarboxylase (Samdc) genes by methyl jasmonate. Plant Physiol Biochem 48 (7) 553–559.

Peremarti A, Bassie L, Zhu C, Christou P, Capell T (2010) Molecular characterization of the arginine decarboxylase gene family in rice. Transgenic Res 19 (5) 785–797.

Polesani M, Bortesi L, Ferrarini A, Zamboni A, Fasoli M, Zadra C, Lovato A, Pezzotti M, Delledonne M, Polverari A (2010) General and species-specific transcriptional responses to downy mildew infection in a susceptible (Vitis vinifera) and a resistant (V. riparia) grapevine species. BMC Genomics 11, 117.

Ribbert T, Thepen T, Tur MK, Fischer R, Huhn M, Barth S (2010) Recombinant, ETA'-based CD64 immunotoxins: improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice. Br J Dermatol 163 (2) 279–286.

Royo C, Maccaferri M, Álvaro F, Moragues M, Sanguineti MC, Tuberosa R, Maalouf F, del Moral LFG, Demontis A, Rhouma S, Nachit M, Nserallah N, Villegas D (2010) Understanding the relationships between genetic and phenotypic structures of a collection of elite durum wheat accessions. Field Crops Res 119 (1) 91–105.

Rüping B, Ernst AM, Jekat SB, Nordzieke S, Reineke AR, Müller B, Bornberg-Bauer E, Prüfer D, Noll GA (2010) Molecular and phylogenetic characterization of the sieve element occlusion gene family in Fabaceae and non-Fabaceae plants. BMC Plant Biol 10, 219.

Schubert M, Agdour S, Fischer R, Olbrich Y, Schinkel H, Schillberg S (2010) A monoclonal antibody that specifically binds chitosan in vitro and in situ on fungal cell walls. J Microbiol Biotechnol 20 (8) 1179–1184.

Schmidt T, Lenders M, Hillebrand A, van Deenen N, Munt O, Reichelt R, Eisenreich W, Fischer R, Prüfer D, Gronover CS (2010) Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz. BMC Biochem 11, 11.

Steinmetz NF, Mertens ME, Taurog RE, Johnson JE, Commandeur U, Fischer R, Manchester M (2010) Potato virus X as a novel platform for potential biomedical applications. Nano Letters 10 (1) 305–312.

Tang DQ, Lu JJ, Fang W, Zhang S, Zhou MB (2010) Development, characterization and utilization of GenBank microsatellite markers in Phyllostachys pubescens and related species. Mol Breeding 25 (2) 299–311.

Uhde-Holzem K, Fischer R, Commandeur U (2010) Characterization and diagnostic potential of foreign epitope-presenting Ty1 virus-like particles expressed in Escherichia coli and Pichia pastoris. J Mol Microbiol Biotechnol 18 (1) 52–62.

Uhde-Holzem K, Schlösser V, Viazov S, Fischer R, Commandeur U (2010) Immunogenic properties of chimeric potato virus X particles displaying the hepatitis C virus hypervariable region I peptide R9. J Virol Methods 166 (1–2) 12–20.

Zakri AM, Ziegler A, Torrance L, Fischer R, Commandeur U (2010) Generation and characterization of a scFv against recombinant coat protein of the geminivirus tomato leaf curl New Delhi virus. Arch Virol 155 (3) 335–342.

Zamboni A, Di Carli M, Guzzo F, Stocchero M, Zenoni S, Ferrarini A, Tononi P, Toffali K, Desiderio A, Lilley KS, Pe ME, Benvenuto E, Delledonne M, Pezzotti M (2010) Identification of putative stage-specific grapevine berry biomarkers and omics data integration into networks. Plant Physiol 154 (3) 1439–1459.

Zenoni S, Ferrarini A, Giacomelli E, Xumerle L, Fasoli M, Malerba G, Bellin D, Pezzotti M, Delledonne M (2010) Characterization of transcriptional complexity during berry development in Vitis vinifera using RNA-Seq. Plant Physiol 152 (4) 1787–1795.

Zhou MB, Lu JJ, Zhong H, Tang KX, Tang DQ (2010) Distribution and polymorphism of mariner-like elements in the Bambusoideae subfamily. Plant Syst Evol 289 (1–2) 1–11.

Zhou MB, Zhong H, Zhang QH, Tang KX, Tang DQ (2010) Diversity and evolution of Ty1-copia retroelements in representative tribes of Bambusoideae subfamily. Genetica 138 (8) 861–868.

Barros E, van Staden CA, Lezar S (2009) A microarray-based method for the parallel analysis of genotypes and expression profiles of wood-forming tissues in Eucalyptus grandis. BMC Biotechnol 9, 51.

Bebrone C, Delbruck H, Kupper MB, Schlomer P, Willmann C, Frere JM, Fischer R, Galleni M, Hoffmann KM (2009) The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site. Antimicrob Agents Chemother 53 (10) 4464–4471.

Bortesi L, Rossato M, Schuster F, Raven N, Stadlmann J, Avesani L, Falorni A, Bazzoni F, Bock R, Schillberg S, Pezzotti M (2009) Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco. BMC Biotechnol 9, 22.

Cogotzi L, Giampetruzzi A, Nolke G, Orecchia M, Elicio V, Castellano MA, Martelli GP, Fischer R, Schillberg S, Saldarelli P (2009) An assay for the detection of grapevine leafroll-associated virus 3 using a single-chain fragment variable antibody. Arch Virol 154 (1) 19–26.

Floss DM, Sack M, Arcalis E, Stadlmann J, Quendler H, Rademacher T, Stoger E, Scheller J, Fischer R, Conrad U (2009) Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody. Plant Biotechnol J 7 (9) 899–913.

Gómez P, Rodríguez-Hernández AM, Moury B, Aranda MA (2009) Genetic resistance for the sustainable control of plant virus diseases: breeding, mechanisms and durability. Eur J Plant Pathol 125 (1) 1–22.

Jorissen H, Bektas N, Dahl E, Hartmann A, ten Haaf A, Di Fiore S, Kiefer H, Thess A, Barth S, Klockenbring T (2009) Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer. BMC Cancer 9, 200.

Kampmeier F, Ribbert M, Nachreiner T, Dembski S, Beaufils F, Brecht A, Barth S (2009) Site-specific, covalent labeling of recombinant antibody fragments via fusion to an engineered version of 6-O-alkylguanine DNA alkyltransferase. Bioconjug Chem 20 (5) 1010–1015.

Kensy F, Zang E, Faulhammer C, Tan RK, Büchs J (2009) Validation of a high-throughput fermentation system based on online monitoring of biomass and fluorescence in continuously shaken microtiter plates. Microb Cell Fact 8, 31.

Lalloo R, Maharajh D, Görgens J, Gardiner N, Görgens JF (2009) High-density spore production of a B. cereus aquaculture biological agent by nutrient supplementation. Appl Microbiol Biotechnol 83 (1) 59–66.

Loesing JB, Di Fiore S, Ritter K, Fischer R, Kleines M (2009) Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology. J Gen Virol 90 (6) 1440–1449.

Naqvi S, Zhu C, Farre G, Ramessar K, Bassie L, Breitenbach J, Perez Conesa D, Ros G, Sandmann G, Capell T, Christou P (2009) Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc Natl Acad Sci USA 106 (19) 7762–7767.

Nolke G, Cobanov P, Uhde-Holzem K, Reustle G, Fischer R, Schillberg S (2009) Grapevine fanleaf virus (GFLV)-specific antibodies confer GFLV and Arabis mosaic virus (ArMV) resistance in Nicotiana benthamiana. Mol Plant Pathol 10 (1) 41–49.

Noll GA, Rüping B, Ernst AM, Bucsenez M, Twyman RM, Fischer R, Prüfer D (2009) The promoters of forisome genes MtSEO2 and MtSEO3 direct gene expression to immature sieve elements in Medicago truncatula and Nicotiana tabacum. Plant Mol Biol Rep 27 (4) 526–533.

Otte B, Grunwaldt E, Mahmoud O, Jennewein S (2009) Genome shuffling in Clostridium diolis DSM 15410 for improved 1,3-propanediol production. Appl Environ Microbiol 75 (24) 7610–7616.

Peremarti A, Bassie L, Christou P, Capell T (2009) Spermine facilitates recovery from drought but does not confer drought tolerance in transgenic rice plants expressing Datura stramonium S-adenosylmethionine decarboxylase. Plant Mol Biol 70 (3) 253–264.

Ranft K, Thepen T, Fischer R, Barth S, Stöcker M (2009) Recombinant bispecific single chain antibody fragments induce Fc gamma-receptor-mediated elimination of CD30+ lymphoma cells. Cancer Lett 282 (2) 187–194.

Roth R, Moodley V, van Zyl P (2009) Heterologous expression and optimized production of an Aspergillus aculeatus endo-1,4-beta-mannanase in Yarrowia lipolytica. Mol Biotechnol 43 (2) 112–20.

Safarnejad MR, Fischer R, Commandeur U (2009) Recombinant-antibody-mediated resistance against Tomato yellow leaf curl virus in Nicotiana benthamiana. Arch Virol 154 (3) 457–467.

Schiermeyer A, Hartenstein H, Mandal MK, Otte B, Wahner V, Schillberg S (2009) A membrane-bound matrix-metalloproteinase from Nicotiana tabacum cv. BY-2 is induced by bacterial pathogens. BMC Plant Biol 9, 83.

Schwan S, Ferrell N, Hansford D, Spohn U, Heilmann A (2009) Measurement of mechanical forces generated by plant P-protein aggregates (forisomes). Eur Biophys J 38 (4) 533536.

Schwan S, Menzel M, Fritzsche M, Heilmann A, Spohn U (2009) Micromechanical measurements on P-protein aggregates (forisomes) from Vicia faba plants. Biophys Chem 139 (2-3) 99–105.

Shoji Y, Bi H, Musiychuk K, Rhee A, Horsey A, Roy G, Green B, Shamloul M, Farrance CE, Taggart B, Mytle N, Ugulava N, Rabindran S, Mett V, Chichester JA, Yusibov V (2009) Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza. Vaccine 27 (7) 1087–1092.

Sorrentino A, Schillberg S, Fischer R, Porta R, Mariniello L (2009) Molecular farming of human tissue transglutaminase in tobacco plants. Amino Acids 36 (4) 765–772.

Tur MK, Neef I, Jost E, Galm O, Jager G, Stöcker M, Ribbert M, Osieka R, Klinge U, Barth S (2009) Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells. J Immunother 32 (5) 431–441.

Wahler D, Schulze Gronover C, Richter C, Foucu F, Twyman RM, Moerschbacher BM, Fischer R, Muth J, Prüfer D (2009) Polyphenoloxidase silencing affects latex coagulation in Taraxacum spp. Plant Physiol 151 (1) 334–346.

Abranches R, Arcalis E, Marcel S, Altmann F, Ribeiro-Pedro M, Rodriguez J, Stoger E (2008) Functional specialization of Medicago truncatula leaves and seeds does not affect the subcellular localization of a recombinant protein. Planta 227 (3) 649–658.

Barros E, Crampton M, Marais G, Lezar S (2008) A DNA-based method to quantify Stenocarpella maydis in maize. Maydica 53 (1) 125–129.

Daghan H, Schaeffer A, Fischer R, Commandeur U (2008) Phytoextraction of cadmium from contaminated soil using transgenic tobacco plants. J Intl Env Appl Sci 3 (5) 336–345.

Danker T, Dreesen B, Offermann S, Horst I, Peterhänsel C (2008) Trimethylation of histone H3 lysine 4 is associated with cell type specificity but not promoter activity of photosynthetic genes in maize. Plant J 53 (3) 465–474.

Engels B, Dahm P, Jennewein S (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 10 (3–4) 201–206.

Hetzel C, Bachran C, Fischer R, Fuchs H, Barth S, Stocker M (2008) Small cleavable adapters enhance the specific cytotoxicity of a humanized immunotoxin directed against CD64-positive cells. J Immunother 31 (4) 370–376.

Maharajh D, Lalloo R, Görgens J (2008) Effect of an exponential feeding regime on the production of Rhodotorula araucariae epoxide hydrolase in Yarrowia lipolytica. Lett Appl Microbiol 47 (6) 520–525.

Muth J, Hartje S, Twyman RM, Hofferbert H-R, Tacke E, Prufer D (2008) Precision breeding for novel starch variants in potato. Plant Biotechnol J 6 (8) 576–584.

Nachreiner T, Kampmeier F, Thepen T, Fischer R, Barth S, Stocker M (2008) Depletion of autoreactive B-lymphocytes by a recombinant myelin oligodendrocyte glycoprotein-based immunotoxin. J Neuroimmunol 195 (1–2) 28–35.

Nickel H, Kawchuk L, Twyman RM, Zimmermann S, Junghans H, Winter S, Fischer R, Prufer D (2008) Plantibody-mediated inhibition of the Potato leafroll virus P1 protein reduces virus accumulation. Virus Res 136 (1–2) 140–145.

Offermann S, Dreesen B, Horst I, Danker T, Jaskiewicz M, Peterhansel C (2008) Developmental and environmental signals induce distinct histone acetylation profiles on distal and proximal promoter elements of the C4-Pepc gene in maize. Genetics 179 (4) 1891–1901.

Orecchia M, Nolke G, Saldarelli P, Dell'Orco M, Uhde-Holzem K, Sack M, Martelli G, Fischer R, Schillberg S (2008) Generation and characterization of a recombinant antibody fragment that binds to the coat protein of Grapevine leafroll-associated virus 3. Arch Virol 153 (6) 1075–1084.

Polesani M, Desario F, Ferrarini A, Zamboni A, Pezzotti M, Kortekamp A, Polverari A (2008) cDNA-AFLP analysis of plant and pathogen genes expressed in grapevine infected with Plasmopara viticola. BMC Genomics 9, 142.

Rademacher T, Sack M, Arcalis E, Stadlmann J, Balzer S, Altmann F, Quendler H, Stiegler G, Kunert R, Fischer R, Stoger E (2008) Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans. Plant Biotechnol J 6 (2) 189–201.

Ramessar K, Rademacher T, Sack M, Stadlmann J, Platis D, Stiegler G, Labrou N, Altmann F, Ma J, Stoger E, Capell T, Christou P (2008) Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc Natl Acad Sci USA 105 (10) 3727–3732.

Schinkel H, Jacobs P, Schillberg S, Wehner M (2008) Infrared picosecond laser for perforation of single plant cells. Biotechnol Bioeng 99 (1) 244–248.

Stahnke B, Thepen T, Stocker M, Rosinke R, Jost E, Fischer R, Tur MK, Barth S (2008) Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. Mol Cancer Ther 7 (9) 2924–2932.

Stocker M, Pardo A, Hetzel C, Reutelingsperger C, Fischer R, Barth S (2008) Eukaryotic expression and secretion of EGFP-labeled annexin A5. Protein Expr Purif 58 (2) 325–331.

Truniger V, Nieto C, González-Ibeas D, Aranda MA (2008) Mechanism of plant eIF4E-mediated resistance against a Carmovirus (Tombusviridae): cap-independent translation of a viral RNA controlled in cis by an (a)virulence determinant. Plant J 56 (5) 716–727.

Wullner U, Neef I, Eller A, Kleines M, Tur MK, Barth S (2008) Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2. Curr Cancer Drug Targets 8 (7) 554–565.

Zamboni A, Minoia L, Ferrarini A, Tornielli GB, Zago E, Delledonne M, Pezzotti M (2008) Molecular analysis of post-harvest withering in grape by AFLP transcriptional profiling. J Exp Bot 59 (15) 4145–4159.

Zhu C, Naqvi S, Breitenbach J, Sandmann G, Christou P, Capell T (2008) Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize. Proc Natl Acad Sci USA 105 (47) 18232–18237.

Avesani L, Marconi G, Morandini F, Albertini E, Bruschetta M, Bortesi L, Pezzotti M, Porceddu A (2007) Stability of Potato virus X expression vectors is related to insert size: implications for replication models and risk assessment. Transgenic Res 16 (5) 587–597.

Kebeish R, Niessen M, Thiruveedhi K, Bari R, Hirsch HJ, Rosenkranz R, Stäbler N, Schönfeld B, Kreuzaler F, Peterhänsel C (2007) Chloroplastic photorespiratory bypass increases photosynthesis and biomass production in Arabidopsis thaliana. Nature Biotechnol 25 (5) 593–599.

Knoll A, Bartsch S, Husemann B, Engel P, Schroer K, Ribeiro B, Stöckmann C, Seletzky J, Büchs J (2007) High cell density cultivation of recombinant yeasts and bacteria under non-pressurized and pressurized conditions in stirred tank bioreactors. J Biotechnol 132 (2) 167–179.

Mett V, Shamloul AM, Hirai H, Zhou Z, Notkins A, Yusibov V (2007) Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plants. Transgenic Res 16 (1) 77–84.

Noll GA, Fontanellaz ME, Rüping B, Ashoub A, van Bel AJ, Fischer R, Knoblauch M, Prüfer D (2007) Spatial and temporal regulation of the forisome gene for1 in the phloem during plant development. Plant Mol Biol 65 (3) 285–294.

Ribbert M, Wolters A, Barth S, Stocker M, Schaeffer A, Fischer R, Finnern R (2007) Immunodetection of Venturia inaequalis ascospores with phage antibodies. J Phytopathol 155 (3) 170–177.

Sack M, Paetz A, Kunert R, Bomble M, Hesse F, Stiegler G, Fischer R, Katinger H, Stoeger E, Rademacher T (2007) Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. FASEB J 21 (8) 1655–1664.

Schwan S, Fritzsche M, Cismak A, Heilmann A, Spohn U (2007) In vitro investigation of the geometric contraction behavior of chemo-mechanical P-protein aggregates (forisomes). Biophys Chem 125 (2-3) 444–452.

Uhde-Holzem K, Fischer R, Commandeur U (2007) Genetic stability of recombinant potato virus X virus vectors presenting foreign epitopes. Arch Virol 152 (4) 805–811.

Drakakaki G, Marcel S, Arcalis E, Altmann F, Gonzalez-Melendi P, Fischer R, Christou P, Stoger E (2006) The intracellular fate of a recombinant protein is tissue dependent. Plant Physiol 141 (2) 578–586.

Drakakaki G, Zabotina O, Delgado I, Robert S, Keegstra K, Raikhel N (2006) Arabidopsis reversibly glycosylated polypeptides 1 and 2 are essential for pollen development. Plant Physiol 142 (4) 1480–1492.


Abranches R, Marcel S, Arcalis E, Altmann F, Fevereiro P, Stoger E (2005) Plants as bioreactors: a comparative study suggests that Medicago truncatula is a promising production system. J Biotechnol 120 (1) 121–134.

Agrawal PK, Kohli A, Twyman RM, Christou P (2005) Transformation of plants with multiple cassettes generates simple transgene integration patterns and high expression levels. Mol Breeding 16 (3) 247–260.

Bruell D, Bruns CJ, Yezhelyev M, Huhn M, Müller J, Ischenko I, Fischer R, Finnern R, Jauch KW, Barth S (2005) Recombinant anti-EGFR immunotoxin 425(scFv)-ETA' demonstrates anti-tumor activity against disseminated human pancreatic cancer in nude mice. Int J Mol Med 15 (2) 305–313.

Drakakaki G, Marcel S, Glahn RP, Lund EK, Pariagh S, Fischer R, Christou P, Stoger E (2005) Endosperm-specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron. Plant Mol Biol 59 (6) 869–880.

Fitter AH, Gilligan CA, Hollingworth K, Kleczkowski A, Twyman RM, Pitchford JW, the members of the NERC Soil Biodiversity Programme (2005) Biodiversity and ecosystem function in soil. Functional Ecol 19 (3) 369–377.

Girardi CL, Corrent AR, Lucchetta L, Zanuzo MR, Zanatta J, Da Costa TS, Twyman RM, Nora FR, Nora L, Silva JA, Rombaldi CV (2005) Effect of ethylene, intermittent warming and controlled atmosphere on postharvest quality and the occurrence of wooliness in peach (Prunus persica cv. Chiripa) during cold storage. Postharvest Biol Technol 38 (1) 25–33.

Kuepper MB, Huhn M, Spiegel H, Ma JK, Barth S, Fischer R, Finnern R (2005) Generation of human antibody fragments against Streptococcus mutans using a phage display chain shuffling approach. BMC Biotechnol 5, 4.

Mehlo L, Gahakwa D, Nghia PT, Loc NT, Capell T, Gatehouse JA, Gatehouse AM, Christou P (2005) An alternative strategy for sustainable pest resistance in genetically enhanced crops. Proc Natl Acad Sci USA 102 (22) 7812–7816.

Nicholson L, Gonzalez-Melendi P, van Dolleweerd C, Tuck H, Perrin Y, Ma JK, Fischer R, Christou P, Stoger E (2005) A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol J 3 (1) 115–127.

Nolke G, Schneider B, Fischer R, Schillberg S (2005) Immunomodulation of polyamine biosynthesis in tobacco plants has a significant impact on polyamine levels and generates a dwarf phenotype. Plant Biotechnol J 3 (2) 237–247.

Paetz A, Sack M, Thepen T, Tur MK, Bruell D, Finnern R, Fischer R, Barth S (2005) Recombinant soluble human Fc-gamma receptor I with picomolar affinity for immunoglobulin G. Biochem Biophys Res Commun 338 (4) 1811–1817.

Schiermeyer A, Schinkel H, Apel S, Fischer R, Schillberg S (2005) Production of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAalpha1) in tobacco is hampered by proteolysis. Biotechnol Bioeng 89 (7) 848–858.

Schinkel H, Schiermeyer A, Soeur R, Fischer R, Schillberg S (2005) Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells. Transgenic Res 14 (3) 251–259.

Stöcker M, Klockenbring T, Huhn M, Nachreiner T, Wicklein D, Petersen A, Bauer R, Goerlich R, Fischer R, Barth S (2005) Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins. J Allergy Clin Immunol 116 (4) 910–915.

Uhde K, Fischer R, Commandeur U (2005) Expression of multiple foreign epitopes presented as synthetic antigens on the surface of Potato virus X particles. Arch Virol 150 (2) 327340.

von der Decken V, Delbrück H, Herrler A, Beier HM, Fischer R, Hoffmann KM (2005) Recombinant bovine uteroglobin at 1.6 A resolution: a preliminary X-ray crystallographic analysis. Acta Crystallogr Se 61 (5) 499–502. 

Arcalis E, Marcel S, Altmann F, Kolarich D, Drakakaki G, Fischer R, Christou P, Stoger E (2004) Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm. Plant Physiol 136 (3) 3457–3466.

Capell T, Bassie L, Christou P (2004) Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress. Proc Natl Acad Sci USA 101 (26) 9909–9914.

Di Fiore S, Hoppmann V, Fischer R, Schillberg S (2004) Transient gene expression of recombinant terpenoid indole alkaloid enzymes in Catharanthus roseus leaves. Plant Mol Biol Rep 22 (1) 15–22.

Gaur RK, Kupper MB, Fischer R, Hoffmann KMV (2004) Preliminary X-ray analysis of a human VH fragment at 1.8 Å resolution. Acta Cryst D60, 965–967. 

Kohli A, Prynne MQ, Miro B, Pereira A,Twyman RM, Capell T, Christou P (2004) Dedifferentiation-mediated changes in transposition behavior make the Activator transposon an ideal tool for functional genomics in rice. Mol Breeding 13 (2) 177–191.

Peschen D, Li HP, Fischer R, Kreuzaler F, Liao YC (2004) Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen. Nature Biotechnol 22 (6) 732–738.

Phlippen N, Hoffmann K, Fischer R, Wolf K, Zimmermann M (2003) The glutathione synthetase of Schizosaccharomyces pombe is synthesized as a homodimer but retains full activity when present as a heterotetramer. J Biol Chem 278 (41) 40152–40161.

Silva JA, da Costa TS, Lucchetta L, Marini LJ, Zanuzo MR, Nora L, Nora FR, Twyman RM, Rombaldi CV (2004) Characterization of ripening behavior in transgenic melons expressing an antisense 1-aminocyclopropane-1-carboxylate (ACC) oxidase gene from apple. Postharvest Biol Technol 32 (3) 263–268.

Sriraman R, Bardor M, Sack M, Vaquero C, Faye L, Fischer R, Finnern R, Lerouge P (2004) Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues. Plant Biotechnol J 2 (4) 279–287.

Vogt U, Pélissier T, Pütz A, Razvi F, Fischer R, Wassenegger M (2004) Viroid-induced RNA silencing of GFP-viroid fusion transgenes does not induce extensive spreading of methylation or transitive silencing. Plant J 38 (1) 107–118.

Li HP, Fu CY, Peschen D, Ling XY, Fischer R, Liao YC (2003) Cloning and characterization of a gene coding for a class I chitin synthase from Fusarium graminearum. Canad J Plant Pathol 25 (3) 240–248.

Trung-Nghia P, Bassie L, Safwat G, Thu-Hang P, Lepri O, Rocha P, Christou P, Capell T (2003) Reduction in the endogenous arginine decarboxylase transcript levels in rice leads to depletion of the putrescine and spermidine pools with no concomitant changes in the expression of downstream genes in the polyamine biosynthetic pathway. Planta 218 (1) 125134.

Lepri O, Bassie L, Thu-Hang P, Christou P, Capell T (2002) Endogenous enzyme activities and polyamine levels in diverse rice cultivars depend on the genetic background and are not affected by the presence of the hygromycin phosphotransferase selectable marker. Theor Appl Genet 105 (4) 594–603.

Loc NT, Tinjuangjun P, Gatehouse AMR, Christou P, Gatehouse JA (2002) Linear transgene constructs lacking vector backbone sequences generate transgenic rice plants which accumulate higher levels of proteins conferring insect resistance. Mol Breeding 9 (4) 231–244.

Thu-Hang P, Bassie L, Safwat G, Trung-Nghia P, Christou P, Capell T (2002) Expression of a heterologous S-adenosylmethionine decarboxylase cDNA in plants demonstrates that changes in S-adenosyl-L-methionine decarboxylase activity determine levels of the higher polyamines spermidine and spermine. Plant Physiol 129 (4) 1744–1754.

Elumalai S, Bassie L, Christou P, Capell T (2001) Development of a novel gene transfer system for Cajanus cajan and expression of a monocot arginine decarboxylase cDNA in transformed cell lines. Plant Physiol Biochem 39 (7–8) 575–582.

Kohli A, Xiong J, Greco R, Christou P, Pereira A (2001) Tagged transcriptome display (TTD) in indica rice using Ac transposition. Mol Genet Genomics 266 (1) 1–11.

Lepri O, Bassie L, Safwat G, Thu-Hang P, Trung-Nghia P, Holtta E, Christou P, Capell T (2001) Over-expression of a cDNA for human ornithine decarboxylase in transgenic rice plants alters the polyamine pool in a tissue-specific manner. Mol Genet Genomics 266 (2) 303–312.

Maqbool SB, Riazuddin S, Loc NT, Gatehouse AMR, Gatehouse JA, Christou P (2001) Expression of multiple insecticidal genes confers broad resistance against a range of different rice pests. Mol Breeding 7 (1) 85–93.

Stöger E, Parker M, Christou P, Casey R (2001) Pea legumin overexpressed in wheat endosperm assembles into an ordered paracrystalline matrix. Plant Physiol 125 (4) 17321742.

Tang K, Sun X, Hu Q, Wu A, Lin C-H, Lin H-J, Twyman RM, Christou P, Feng T (2001) Transgenic rice plants expressing the ferredoxin-like protein (AP1) from sweet pepper show enhanced resistance to Xanthomonas oryzae pv. oryzae . Plant Sci 160 (5) 1035–1042.

Torres E, Gonzalez-Melendi P, Stoger E, Shaw P, Twyman RM, Nicholson L, Vaquero C, Fischer R, Christou P, Perrin Y (2001) Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments. Plant Physiol 127 (3) 1212–1223.


Abranches R, Santos AP, Wegel E, Williams S, Castilho A, Christou P, Shaw P, Stoger E (2000) Widely separated multiple transgene integration sites in wheat chromosomes are brought together at interphase. Plant J 24 (6) 713–723.

Bassie L, Noury M, Lepri O, Lahaye T, Christou P, Capell T (2000) Promoter strength influences polyamine metabolism and morphogenic capacity in transgenic rice tissues expressing the oat adc cDNA constitutively. Transgenic Res 9 (1) 33–42.

Bassie L, Noury M, Wisnieski JP, Topsom L, Christou P, Capell T (2000) Transgenic cell lines as a useful tool to study the biochemistry of down-regulation of an endogenous rice gene using a heterologous diamine oxidase cDNA. Plant Physiol Biochem 38 (10) 729–737.

Drakakaki G, Christou P, Stoger E (2000) Constitutive expression of soybean ferritin cDNA in transgenic wheat and rice results in increased iron levels in vegetative tissues but not in seeds. Transgenic Res 9 (6) 445–452.

Fu X, Duc LT, Fontana S, Bong BB, Tinjuangjun P, Sudhakar D,Twyman RM, Christou P, Kohli A (2000) Linear transgene constructs lacking vector backbone sequences generate low-copy-number transgenic plants with simple integration patterns. Transgenic Res 9 (1) 11–19.

Fu X, Kohli A, Twyman RM, Christou P (2000) Alternative silencing effects involve distinct types of non-spreading cytosine methylation at a three-gene single-copy transgenic locus in rice. Mol Gen Genet 263 (1) 106–118.

GahakwaS D, Maqbool SB, Fu X, Sudhakar D, Christou P, Kohli A (2000) Transgenic rice as a system to study the stability of transgene expression: multiple heterologous transgenes show similar behaviour in diverse genetic backgrounds. Theor Appl Genet 101 (3) 388–399.

Kurek I, Stöger E, Dulberger R, Christou P, Breiman A (2002) Overexpression of the wheat FK506-binding protein 73 (FKBP73) and the heat-induced wheat FKBP77 in transgenic wheat reveals different functions of the two isoforms. Transgenic Res 11 (4) 373–379.

Mazithulela G, Sudhakar D, Heckel T, Mehlo L, Christou P, Davies JW, Boulton MI (2000) The maize streak virus coat protein transcription unit exhibits tissue-specific expression in transgenic rice. Plant Sci 155 (1) 21–29.

Mehlo L, Mazithulela G, Twyman RM, Boulton MI, Davies JW, Christou P (2000) Structural analysis of transgene rearrangements and effects on expression in transgenic maize plants generated by particle bombardment. Maydica 45 (4) 277–287.

Morello L, Frattini M, Giani S, Christou P, Breviario D (2000) Overexpression of the calcium-dependent protein kinase OsCDPK2 in transgenic rice is repressed by light in leaves and disrupts seed development. Transgenic Res 9 (6) 453–462.

Noury M, Bassie L, Lepri O, Kureck I, Christou P, Capell T (2000) A transgenic rice cell lineage expressing the oat arginine decarboxylase (adc) cDNA constitutively accumulates putrescine in callus and seeds but not in vegetative tissues. Plant Mol Biol 43 (4) 537–544.

Perrin Y, Vaquero C, Gerrard I, Sack M, Drossard J, Stoger E, Christou P, Fischer R (2000) Transgenic pea seeds as bioreactors for the production of a single chain Fv fragment (scFv) antibody used for cancer diagnosis and therapy. Mol Breeding 6 (4) 345–352.

Stoger E, Vaquero C, Torres E, Sack M, Nicholson L, Drossard J, Williams S, Keen D, Perrin Y, Christou P, Fischer R (2000) Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies. Plant Mol Biol 42 (4) 583–590.

Tinjuangjun P, Loc, NT, Gatehouse AMR, Gatehouse JA, Christou P (2000) Enhanced insect resistance in Thai rice varieties generated by particle bombardment. Mol Breeding 6 (4) 391–399.

Zeef LA, Christou P, Leech MJ (2000) Transformation of the tropane alkaloid-producing medicinal plant Hyoscyamus muticus by particle bombardment. Transgenic Res 9 (3) 163168.

 Before 2000 

Frattini M, Morello L, Breviario D (1999) Rice calcium-dependent protein kinase isoforms OsCDPK2 and OsCDPK11 show different responses to light and different expression patterns during seed development. Plant Mol Biol 41 (6) 753–764.

Hilliou F, Christou P, Leech MJ (1999) Development of an efficient transformation system for Catharanthus roseus cell cultures using particle bombardment. Plant Sci 140 (2) 179188.

Kohli A, Gahakwa D, Vain P, Laurie DA, Christou P (1999) Transgene expression in rice engineered through particle bombardment: molecular factors controlling stable expression and transgene silencing. Planta 208 (1) 88–97.

Kohli A, Griffiths S, Palacios N, Twyman RM, Vain P, Laurie DA, Christou P (1999) Molecular characterization of transforming plasmid rearrangements in transgenic rice reveals a recombination hotspot in the CaMV 35S promoter and confirms the predominance of microhomology mediated recombination. Plant J 17 (6) 591–601.

Maqbool SB, Christou P (1999) Multiple traits of agronomic importance in transgenic indica rice plants: analysis of transgene integration patterns, expression levels and stability. Mol Breeding 5 (5) 471–480.

Stoger E, Williams S, Keen D, Christou P (1999) Constitutive versus seed specific expression in transgenic wheat: temporal and spatial control. Transgenic Res 8 (2) 73–82.

Stoger E, Williams S, Keen D, Christou P (1999) Molecular characteristics of transgenic wheat and the effect on transgene expression. Transgenic Res 7 (6) 463–471.

Tang K, Tinjuangjun P, Xu Y, Sun X, Gatehouse JA, Ronald PC, Qi H, Lu X, Christou P, Kohli A (1999) Particle bombardment-mediated co-transformation of elite Chinese rice cultivars with genes conferring resistance to bacterial blight and sap-sucking insect pests. Planta 208 (4) 552–563.

Torres E, Vaquero C, Nicholson L, Sack M, Stoger E, Drossard J, Christou P, Fischer R, Perrin Y (1999) Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies. Transgenic Res 8 (6) 441–449.

Vain P, Worland B, Kohli A, Snape JW, Christou P, Allen GC, Thompson WF (1999) Matrix attachment regions increase transgene expression levels and stability in transgenic rice plants and their progeny. Plant J 18 (3) 233–242.

Kohli A, Leech M, Vain P, Laurie DA, Christou P (1998) Transgene organization in rice engineered through direct DNA transfer supports a two-phase integration mechanism mediated by the establishment of integration hot spots. Proc Natl Acad Sci USA 95 (12) 7203–7208.

Leech MJ, May K, Hallard D, Verpoorte R, De Luca V, Christou P (1998) Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation. Plant Mol Biol 38 (5) 765–774.

Maqbool SB, Husnain T, Riazuddin S, Masson L, Christou P (1998) Effective control of yellow stem borer and rice leaf folder in transgenic rice indica varieties Basmati 370 and M 7 using the novel delta-endotoxin cry2A Bacillus thuringiensis gene. Mol Breeding 4 (6) 501–507.

Sudhakar D, Fu X, Stoger E, Williams S, Spence J, Brown DP, Bharathi M, Gatehouse JA, Christou P (1998) Expression and immunolocalisation of the snowdrop lectin, GNA in transgenic rice plants. Transgenic Res 7 (5) 371–378.

Twyman RM, Jones EA (1997) Sequences in the proximal 5' flanking region of the rat neuron-specific enolase (NSE) gene are sufficient for cell type-specific reporter gene expression. J Mol Neurosci 8 (1) 63–73.

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