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Book Chapters

 2017 and in press  

 

Allen L (2017) The evolution of platform technologies for the downstream processing of antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 365–390.

Arunakumari A, Wang J (2017) Purification of human monoclonal antibodies: non-protein A strategies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 135–154.

Buyel JF (2017) How plants can contribute to the supply of anti-cancer compounds. In Malik S (ed) Biotechnology and Production of Anti-Cancer Compounds. Springer NY (in press).

Buyel JF, Twyman RM, Fischer R (2017) Very-large-scale production of monoclonal antibodies in plants. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 655–672.

Chabanne C, Santarelli X (2017) Purification of IgM and IgA. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 615–630.

Curling J (2017) The development of antibody purification technologies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 23–54.

Etzel MR, Arunkumar A (2017) Charged ultrafiltration and microfiltration membranes for antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 247–268.

Farid SS (2017) Process economic drivers in industrial monoclonal antibody manufacture. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 445–466.

Fischer R, Holland T, Sack M, Schillberg S, Stoger E, Twyman RM, Buyel JF (2017) Glyco-engineering of plant-based expression systems. In: Rapp E, Reichl U (eds) Advances in Glycobiotechnology: Advances in Biochemical Engineering/Biotechnology. Springer, NY (in press).

Fontes N, Van Reis R (2017) Advances in technology and process development for industrial scale monoclonal antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 199–214.

Gagnon P (2017) Purification of monoclonal antibodies by mixed mode chromatography. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 181–198.

Ghose S, Jin M, Liu J, Hickey J, Lee S (2017) Integrated polishing steps for monoclonal antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 303–324.

Glynn J (2017) Process-scale precipitation of impurities in mammalian cell culture broth. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 233–246.

Grein TA, Weidner T, Czermak P (2017) Production of virus particles. In Gower S (ed) Cell Culture. InTech, Rijeka, Croatia (published online ahead of print).

Hahn T, Huuk T, Hubbuch J (2017) High-throughput screening and modeling technologies for process development in antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 515–536.
Hundleby PAC, Sack M, Twyman RM (2016) Biosafety, risk assessment and regulation of molecular farming. In: Kermode A, Fraser S, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-VCH, Mannheim, Germany (in press).

Kelley B (2017) Downstream processing of monoclonal antibodies: current practices and future opportunities. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 1–22,

Leber J, Elseberg C, Weidner T, Czermak P (2017) Expansion of human mesenchymal stem cells in different bioreactor systems. In Gower S (ed) Cell Culture. InTech, Rijeka, Croatia (published online ahead of print).

Li Y, Zhu M, Luo H, Weaver JR (2017) Development of a platform process for the purification of therapeutic monoclonal antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 343–364.

Mahler H-C, Mathäs R (2017) Trends in formulation and drug delivery for antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 673–698.

Mothes B (2017) Accelerated seamless antibody purification: simplicity is key. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 431–444.

Müller-Späth T, Morbidelli M (2017) Continuous chromatography for the purification of monoclonal antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 391–408.

Nikolov ZL, Regan JT, Dickey LF, Woodard SL (2017) Purification of antibodies from plants. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 631–654.

Pujar N, Low D, O’Leary R (2017) Antibody purification: drivers of change. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 699–716.

Rohrer T (2017) Manufacturing concepts for antibody–drug conjugates. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 595–614.

Schillberg S, Raven N, Fischer R, Twyman RM, Schiermeyer A (2017) Contained molecular farming using plant cell and tissue cultures. In: Yoshida T (ed) Applied Bioengineering. Innovations and Future Directions. Wiley-VCH Verlag, Weinheim, Germany, pp 261281.  DOI   PDF

Shukla AA, Norman CL (2017) Downstream processing of Fc fusion proteins, bispecific antibodies and antibody–drug conjugates. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 559–594.

Shukla AA, Suda E (2017) Harvest and recovery of monoclonal antibodies: cell removal and clarification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 55–80.

Sinclair A (2017) Design and optimization of manufacturing. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 467–494.
Singh N, Chollangi S (2017) Next-generation clarification technologies for the downstream processing of antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 81–112.
Spiegel H, Stöger E, Twyman RM, Buyel JF (2017) Current status and perspectives of the molecular farming landscape. In: Kermode A, Fraser S, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-VCH, Mannheim, Germany (in press).

Spitali M (2017) Downstream processing of monoclonal antibody fragments. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK pp 537–558.
Sprick G, Zitzmann J, Weidner T, Czermak P (2017) Process optimization for recombinant protein expression in insect cells. In Gower S (ed) Cell Culture. InTech, Rijeka, Croatia (published online ahead of print).

Thömmes J, Twyman RM, Gottschalk U (2017) Alternatives to packed-bed chromatography for antibody extraction and purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 215–232.

Tingley SK (2017) Disposable prepacked bed chromatography for downstream purification: form, fit, function and industry adoption. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 269–302.
Vajda J, Müller E (2017) Hydrophobic interaction chromatography for the purification of antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 155–180.
Vunnum S, Vedantham G, Hubbard B (2017) Protein A-based affinity chromatography. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 113-134.
Zhou JX (2017) Orthogonal virus clearance applications in monoclonal antibody production. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 325–342.
Zhou JX, Li J, Cui M, Chen H (2017) Smart design for an efficient facility with a validated disposable system. In: Gottschalk U (ed) Process-scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 495–514.


 2016  

Bellin D, Delledonne M, Vandelle E (2016) Detection of peroxynitrite in plants exposed to bacterial infection. In Gupta KJ (ed) Plant Nitric Oxide Methods and Protocols. Methods in Molecular Biology 1424, Humana Press (Springer, NY, USA),  pp 191–200.

Boes A, Reimann A, Twyman RM, Fischer R, Schillberg S, Spiegel H (2016) A plant-based transient expression system for the rapid production of malaria vaccine candidates. In Thomas S (ed) Vaccine Design Methods and Protocols, Volume 2 Vaccines for Veterinary Diseases. Methods in Molecular Biology 1404, Humana Press (Springer, NY, USA),  pp 597619.

Mukherjee K, Baudach A (2016) Epigenetic control of polyphenism in aphids. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 89–99.

Peschen D, Schillberg S, Fischer R (2016) Antibody-mediated pathogen resistance in plants. In MacDonald J, Kolotilin I, Menassa R (eds) Recombinant Proteins from Plants. Methods in Molecular Biology 1385, Humana press (Springer, NY, USA), pp 273–291.

Schmidtberg H, Vilcinskas A (2016) The ontogenesis of the pea aphid Acyrthosiphon pisum. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 14–51.

Skaljac M (2016) Bacterial symbionts of aphids (Hemiptera: Aphididae). In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 100–125.

Vilcinskas A (2016) Aphid immunity. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 126–134.

Will T (2016) Aphid techniques. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 255–270.


 2011-2015 

 

Cremer C, Hehmann-Titt G, Schiffer S, Melmer G, Carloni P, Barth S, Nachreiner T (2015) Engineered versions of granzyme B and angiogenin overcome intrinsic resistance to apoptosis mediated by human cytolytic fusion proteins. In: Verma RS, Bonavida B (eds) Resistance to Immunotoxins in Cancer Therapy (Resistance to Targeted Anti-Cancer Therapeutics Volume 6). Springer International, NY, USA, pp 185–219.

Fischer R, Buyel JF, Schillberg S, Twyman RM (2014) Molecular farming in plants: The long road to the market. In: Howard JA, Hood EE (eds) Commercial Plant-Produced Recombinant Protein Products. Biotechnology in Agriculture and Forestry, Volume 68. Springer Verlag, Berlin, pp 27–41.


Joop G, Vilcinskas A (2014) Evolutionary ecology of insect immunity. In: Hoffmann KH (ed) Insect Molecular Biology and Ecology. CRC Press, Boca Raton, FL, USA, pp 271–290.


Worden N, Girke T, Drakakaki G (2014) Endomembrane dissection using chemically induced bioactive clusters. In: Hicks GR, Robert S (eds) Plant Chemical Genomics. Methods in Molecular Biology 1056, Humana Press (Springer, NY, USA), pp 159–168.


Barth S, Gattenlöhner S, Tur MK (2013) Immunokinases. In: Schmidt SR (ed) Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. Blackwell-Wiley, NY, USA, pp 329–336.


Brandt A, Vilcinskas A (2013) The fruit fly Drosophila melanogaster as a model for aging research. In: Vilcinskas A (ed) Yellow Biotechnology I - Insect Biotechnology in Drug Discovery and Preclinical Research. Adv Biochem Eng Biotechnol, Volume 135. Springer, NY, USA, pp 63–77.


Fischer R, Ostafe R, Twyman RM (2013) Cellulases from insects. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 51–64.


Knorr E, Bingsohn L, Kanost MR, Vilcinskas A (2013) Tribolium castaneum as a model for high-throughput RNAi screening. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 163–178.

 

Mukherjee K, Raju R, Fischer R (2013) Galleria mellonella as a model host to study gut microbe homeostasis and brain infection by the human pathogen Listeria monocytogenes. In: Vilcinskas A (ed) Yellow Biotechnology I - Insect Biotechnology in Drug Discovery and Preclinical Research. Adv Biochem Eng Biotechnol, Volume 135. Springer, NY, pp 27–39.

 

Schott M, Wehrenfennig C, Gasch T (2013) Insect antenna-based biosensors for in situ detection of volatiles. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 101–122.

 

Will T, Vilcinskas A (2013) Aphid-proof plants: biotechnology-based approaches for aphid control. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 179–203.


DalCorso G (2012) Heavy metal toxicity in plants. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 1–25.


Fasani E (2012) Plants that hyperaccumulate heavy metals. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 55–74.


Janzen C, Hoffmann K (2012) Optical measurements for the rational screening of protein crystallization conditions. In: Popp J, Tuchin VV, Chiou A, Heinemann SH (eds) Handbook of Biophotonics, Volume 3. John Wiley & Sons, NJ, USA, pp 257–290.


Manara A (2012) Plant responses to heavy metal toxicity. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 27–53.


Nesler A, Furini A (2012) Phytoremediation: the utilization of plants to reclaim polluted sites. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 75–86.

 

Farré G, Naqvi S, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RM, Capell T, Zhu C, Christou P (2011) Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway. In: Dunwell J (ed) Transgenic Plants: Protocols and Methods. Methods in Molecular Biology 847. Humana Press (Springer, NY, USA), pp 419–435.

 

Gottschalk U (2011) Overview of downstream processing in the biomanufacturing industry. In: Moo-Young M, Butler M, Webb C, Moreira A, Grodzinski B, Cui ZF, Agathos S (eds) Comprehensive Biotechnology, Second Edition. Elsevier/Pergamon, Oxford, UK, pp 669–682.

 

Tappe A, Gottschalk U (2011) Single-use downstream equipment. In: Eibl R, Eibl D (eds) Single-Use Technology in Biopharmaceutical Manufacture. John Wiley & Sons, NJ, USA, pp 91103.  


Tornielli GB, Zamboni A, Zenoni S, Delledonne M, Pezzotti M (2011) Transcriptomics and metabolomics for the analysis of grape berry development. In in Gerós H, Chaves MM, Delrot S (eds) The Biochemistry of the Grape Berry. Bentham Science Publishers, Sharjah, UAE, pp 218–240.

 

Twyman RM, Schillberg S, FIscher R (2011) The production of vaccines and therapeutic antibodies in plants. In: Ma S, Wang A (eds) Molecular Farming in Plants: Recent Advances and Future Prospects. Springer, NY, USA, pp 145–159.

 

Walter JK, Jin Z, Jornitz MW, Gottschalk U (2011) Membrane separations. In Janson J-C (ed) Protein Purification: Principles, High Resolution Methods, and Applications, Third Edition. Methods of Biochemical Analysis, Volume 54. John Wiley & Sons, NJ, USA, pp 279–317.

 


 2001-2010

Gottschalk U (2010) Disposables in downstream processing. In Eibl R, Eibl D (eds) Disposable Bioreactors. Adv Biochem Eng Biotechnol, Volume 115. Springer, Berlin/Heidelberg, pp 171–183.

 

Kohli A, Miro B, Twyman RM (2010) Transgene integration, expression and stability in plants: strategies for improvements. In Kole C, Michler CH, Abbott AG, Hall TC (eds) Biotech Plants, Volume 1: Concepts & Development. Springer-Verlag, Berlin, pp 201–238.


Schiermeyer A, Schillberg S (2010) Pharmaceuticals. In Kempken F, Jung C (eds) Genetic Modification of Plants. Biotechnology in Agriculture and Forestry, Volume 64. Springer NY, USA, pp 221–235.

 

Walter JK, Gottschalk U (2010) Concepts for disposables in biopharmaceutical manufacture. In Shire SJ, Gombotz W, Bechtold-Peters K, Andya J (eds) Current Trends in Monoclonal Antibody Development and Manufacturing. Biotechnology: Pharmaceutical Aspects, Volume IX. Springer, NY, USA, pp 87–99. 

 

Arunakumari A, Wang J (2009) Purification of human monoclonal antibodies: non-protein A strategies. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 103–123.


Cabanne C, Santarelli X (2009) Purification of antibodies other than IgG: the case of IgM and IgA. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 373–386.


Christou P, Capell T (2009) Transgenic crops and their applications for sustainable agriculture and food security. In Ferry N, Gatehouse AMR (eds) Environmental Impact of Genetically Modified Crops, CAB International, Wallingford, UK, pp 3–22.


Curling J (2009) The development of antibody purification technologies. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 25–52.


Etzel MR (2009) Charged ultrafiltration and microfiltration membranes in antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 325–347.


Farid SS (2009) Process economic drivers in industrial monoclonal antibody manufacture. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford UK, pp 239–261.

 

Fischer R, Schillberg S, Twyman RM (2009) Molecular farming of antibodies in plants. In: Kirakosyan A, Kaufman PB (eds) Recent Advances in Plant Biotechnology. Springer, NY, USA, pp 35–63.


Fontes N, van Reis R (2009) Advances in technology and process development for industrial-scale monoclonal antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 203–221.


Gagnon P (2009) Purification of monoclonal antibodies by mixed-mode chromatography. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 125–143.


Ghose S, Jin M, Liu J, Hickey J (2009) Integrated polishing steps for monoclonal antibody purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 145–167.


Glynn J (2009) Process-scale precipitation of impurities in mammalian cell culture broth. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 309–324.


Kelley B, Blank G, Lee A (2009) Downstream processing of monoclonal antibodies: current practices and future opportunities. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 1–23.


Li Y, Kahn DW, Galperina O, Blatter E, Luo R, Wu Y, Zhang G (2009) Development of a platform process for the purification of therapeutic monoclonal antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 187–201.


Müller-Späth T, Morbidelli M (2009) Continuous chromatography for the purification of monoclonal antibodies. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 223–238.


Nikolov ZL, Regan JY, Dickey LF, Woodard SL (2009) Purification of antibodies from transgenic plants. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford UK, pp 387–406.


Pujar N, Low D, O'Leary R (2009) Antibody purification: drivers of change. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 407–426.

 

Ramessar K, Naqvi S, Dashevskaya S, Peremarti A, Yuan D, Gomez-Galera D, Velez SMR, Farre G, Sabalza M, Miralpeix B, Twyman RM, Zhu C, Bassie L, Capell T, Christou P (2009) The contribution of plant biotechnology to food security in the 21st century. In: Amsel L, Hirsch L (eds)  Food Science and Security. Nova Science Publishers, NY, USA, pp 3–72.

 

Shukla AA, Kandula JR (2009) Harvest and recovery of monoclonal antibodies: cell removal and clarification. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 53–78.


Sinclair A (2009) Design and optimization of manufacturing. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 263–291.

 

Sparrow PAC, Twyman RM (2009) Biosafety and risk assessment of plant-made pharmaceuticals. In: Faye L, Gomord V (eds) Recombinant Pharmaceutical Proteins from Plants. Methods in Molecular Biology 483. Humana Press (Springer, NY, USA), pp 341–353.


Spitali M (2009) Downstream processing of monoclonal antibody fragments. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford UK, pp 349–372.

Thömmes J, Gottschalk U (2009) Alternatives to packed-bed chromatography for antibody extraction and purification. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 293–308.

 

Twyman RM (2009) Wnt pathway and neural patterning. In: Lemke G (ed) Developmental Neurobiology. Elsevier Press, Amsterdam, Netherlands, pp 39–44.

 

Twyman RM (2009) Transcriptional silencing. In: Lemke G (ed) Developmental Neurobiology. Elsevier Press, Amsterdam, Netherlands, pp 178–183.


Vunnum S, Vedantham G, Hubbard B (2009) Protein A-based affinity chromatography. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 79–102.


Zenoni S, Zamboni A, Porceddu A, Pezzotti M (2009) The role of expansins A in petunia development. In: Greats T, Strommer J (eds) Petunia. Springer, NY, USA, pp 247–267.


Zhou JX (2009) Orthogonal virus clearance applications in monoclonal antibody production. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 169–186.

 

Fischer R, Twyman RM, Hellwig S, Drossard J, Schillberg S (2007) Facing the future with pharmaceuticals from plants. In: Xu Z, Li J, Xue Y, Yang W (eds) Biotechnology and Sustainable Agriculture 2006 and Beyond. Proceedings of the 11th IAPTC&B Congress, August 13-18, 2006 Beijing, China. Springer, NY, USA, pp 13–32.

 

Gottschalk U (2007) Downstream procesing. In: Jornitz MJ, Meltzer TH (eds) Filtration and Purification in the Biopharmaceutical Industry, Second Edition. Drugs and the Pharmaceutical Sciences, Volume 174. Informa Healthcare NY, USA/London, UK, pp 459–494.

 

Gottschalk U (2007) Downstream processing: removing economic and technical bottlenecks. In: Langer ES (ed) Advances in Large-Scale Biopharmaceutical Manufacturing and Scale-Up Production, Second Edition. BioPlan Associates Inc., Rockville MD/ASM Press, Washington DC, USA, pp 913–948.

 

Twyman RM, Schillberg S, Fischer R (2007) Molecular farming of antibodies in plants. In: Ranalli P (ed) Improvements of Crop Plants for Industrial End Uses.  Springer-Verlag,  NY, USA, pp 435-469.

 

Twyman RM, Schillberg S, Fischer R (2006) Production of therapeutic antibodies and heterologous recombinant proteins in plant systems. In: Kayser O, Quax W (eds) Medicinal Plant Biotechnology. Wiley-VCH, Weinheim, Germany, pp 319–344.


Zimmermann S, Emans N, Fischer R, Schillberg S (2006) Plantibody-based disease resistance in plants. In: Tuzun S, Bent E (eds) Multigenic and Induced Systemic Resistance in Plants. Springer, NY, USA, pp 456–476.

 

Fischer R, Twyman RM, Drossard J, Hellwig S, Schillberg S (2005) Plant cells. In: Gellissen G (ed) Production of Recombinant Proteins: Novel Microbial and Eukaryotic Expression Systems. Wiley-VCH, Weinheim, Germany, pp 253–272.

 

Schillberg S, Twyman RM, Fischer R (2005) Biopharmaceutical production in cultured plant cells. In: Knablein J (ed) Modern Biopharmaceuticals - Design, Development and Optimization. Wiley-VCH,  Weinheim,  Germany,  pp 949–966.

 

Ammann K (2004) The role of science and discourse in the application of the precautionary approach. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 291–302.


Bischoff F (2004) A top-down view of molecular farming from the pharmaceutical industry: requirements and expectations. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 267–290.


Brandle J (2004) The field evaluation of transgenic crops engineered to produce recombinant proteins. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 69–76.


Chargelegue D, Drake PMW, Obregon P, Ma JKC (2004) Production of secretory IgA in transgenic plants. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 159–169.


Christou P, Stoger E, Twyman RM (2004) Monocot expression systems for molecular farming. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 55–67.
 
Commandeur U, Twyman RM (2004) Biosafety aspects of molecular farming in plants. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 251–266.

 

Daniell H, Carmona-Sanchez O, Burns BE (2004) Chloroplast derived antibodies, biopharmaceuticals and edible vaccines. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 113–133.


D'Aoust MA, Busse U, Martel M, Lerouge P, Levesque D, Vézina LP (2004) Perennial plants as a production system for pharmaceuticals. In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, NJ, USA, pp 759–767.


D'Aoust MA, Lerouge P, Busse U, Bilodeau P, Trépanier S, Gomord V, Faye L, Lou Vézina LP (2004) Efficient and reliable production of pharmaceuticals in alfalfa. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 1–12.


Drossard J (2004) Downstream processing of plant-derived recombinant therapeutic proteins. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 217–231.


Giersberg M, Saalbach I, Bäumlein H (2004) Gene farming in pea under field conditions. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 183–190.


Gomord V, Fitchette AC, Lerouge P, Faye L (2004) Glycosylation of plant-made pharmaceuticals. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 233–250.


Hood EE (2004) Plants as enzyme factories. In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, NJ, USA, pp 781–800.


Grill LK (2004) Production of pharmaceutical proteins using viral vectors. In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, NJ, USA, pp 781–789.


Khalsa G, Mason HS, Arntzen CJ (2004) Plant-derived vaccines: progress and constraints. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 135–158.


Koivu K (2004) Novel sprouting technology for recombinant protein production. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 37–53.


Komari T, Ishida U, Hiei Y (2004) Agrobacterium-mediated transformation. In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, NJ, USA, pp 233–261.


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