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Book Chapters

 2017 and in press  

 

Allen L (2017) The evolution of platform technologies for the downstream processing of antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 365–390.  DOI

Arunakumari A, Wang J (2017) Purification of human monoclonal antibodies: non-protein A strategies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 135–154.  DOI

Buyel JF (2017) How plants can contribute to the supply of anti-cancer compounds. In Malik S (ed) Biotechnology and Production of Anti-Cancer Compounds. Springer International, Cham, Switzerland, pp 39–72.  DOI

Buyel JF, Twyman RM, Fischer R (2017) Very-large-scale production of monoclonal antibodies in plants. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 655–672.  DOI

Chabanne C, Santarelli X (2017) Purification of IgM and IgA. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 615–630.  DOI

Curling J (2017) The development of antibody purification technologies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 23–54.  DOI

Elseberg C, Leber J, Weidner T, Czermak P (2017) The challenge of human mesenchymal stromal cell expansion: current and prospective answers. In Gowder SJT (ed) New Insights into Cell Culture Technology. InTech, Rijeka, Croatia, pp 99–134.  DOI

Etzel MR, Arunkumar A (2017) Charged ultrafiltration and microfiltration membranes for antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 247–268.  DOI

Farid SS (2017) Process economic drivers in industrial monoclonal antibody manufacture. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 445–466.  DOI

Fischer R, Holland T, Sack M, Schillberg S, Stoger E, Twyman RM, Buyel JF (2017) Glyco-engineering of plant-based expression systems. In: Rapp E, Reichl U (eds) Advances in Glycobiotechnology: Advances in Biochemical Engineering/Biotechnology. Springer, NY (in press).

Fontes N, Van Reis R (2017) Advances in technology and process development for industrial scale monoclonal antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 199–214.  DOI

Gagnon P (2017) Purification of monoclonal antibodies by mixed mode chromatography. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 181–198.  DOI

Garonzi M, Centomo C, Delledonne M (2017) Next generation sequencing for next generation diagnostics and therapies. In Nadin M (ed) Anticipation and Medicine. Springer International, Cham, Switzerland, pp 87–102.  DOI

Ghose S, Jin M, Liu J, Hickey J, Lee S (2017) Integrated polishing steps for monoclonal antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 303–324.  DOI

Glynn J (2017) Process-scale precipitation of impurities in mammalian cell culture broth. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 233–246.  DOI

Grein TA, Weidner T, Czermak P (2017) Concepts for the production of viruses and viral vectors in cell cultures. In Gowder SJT (ed) New Insights into Cell Culture Technology. InTech, Rijeka, Croatia, pp 173–192.  DOI

Hahn T, Huuk T, Hubbuch J (2017) High-throughput screening and modeling technologies for process development in antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 515–536.  DOI
Hundleby PAC, Sack M, Twyman RM (2016) Biosafety, risk assessment and regulation of molecular farming. In: Kermode A, Fraser S, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-VCH, Mannheim, Germany (in press).

Kelley B (2017) Downstream processing of monoclonal antibodies: current practices and future opportunities. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 1–22.  DOI

Li Y, Zhu M, Luo H, Weaver JR (2017) Development of a platform process for the purification of therapeutic monoclonal antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 343–364.  DOI

Mahler H-C, Mathäs R (2017) Trends in formulation and drug delivery for antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 673–698.  DOI

Mothes B (2017) Accelerated seamless antibody purification: simplicity is key. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 431–444.  DOI

Müller-Späth T, Morbidelli M (2017) Continuous chromatography for the purification of monoclonal antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 391–408.  DOI

Nikolov ZL, Regan JT, Dickey LF, Woodard SL (2017) Purification of antibodies from plants. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 631–654.  DOI

Pujar N, Low D, O’Leary R (2017) Antibody purification: drivers of change. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 699–716.  DOI

Rohrer T (2017) Manufacturing concepts for antibody–drug conjugates. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ pp 595–614.  DOI

Schillberg S, Raven N, Fischer R, Twyman RM, Schiermeyer A (2017) Contained molecular farming using plant cell and tissue cultures. In: Yoshida T (ed) Applied Bioengineering. Innovations and Future Directions. Wiley-VCH Verlag, Weinheim, Germany, pp 261281.  DOI 

Shukla AA, Norman CL (2017) Downstream processing of Fc fusion proteins, bispecific antibodies and antibody–drug conjugates. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 559–594.  DOI

Shukla AA, Suda E (2017) Harvest and recovery of monoclonal antibodies: cell removal and clarification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 55–80.  DOI

Sinclair A (2017) Design and optimization of manufacturing. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 467–494.  DOI
Singh N, Chollangi S (2017) Next-generation clarification technologies for the downstream processing of antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 81–112.  DOI
Spiegel H, Stöger E, Twyman RM, Buyel JF (2017) Current status and perspectives of the molecular farming landscape. In: Kermode A, Fraser S, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. Wiley-VCH, Mannheim, Germany (in press).

Spitali M (2017) Downstream processing of monoclonal antibody fragments. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 537–558.  DOI

Thömmes J, Twyman RM, Gottschalk U (2017) Alternatives to packed-bed chromatography for antibody extraction and purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 215–232.  DOI

Tingley SK (2017) Disposable prepacked bed chromatography for downstream purification: form, fit, function and industry adoption. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). Wiley-Blackwell, Oxford, UK, pp 269–302.  DOI
Vajda J, Müller E (2017) Hydrophobic interaction chromatography for the purification of antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 155–180.  DOI
Vunnum S, Vedantham G, Hubbard B (2017) Protein A-based affinity chromatography. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 113-134.  DOI
Zhou JX (2017) Orthogonal virus clearance applications in monoclonal antibody production. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 325–342.  DOI
Zhou JX, Li J, Cui M, Chen H (2017) Smart design for an efficient facility with a validated disposable system. In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 495–514.  DOI

Zitzmann J, Sprick G, Weidner T, Schreiber C, Czermak P (2017) Process optimization for recombinant protein expression in insect cells. In Gowder SJT (ed) New Insights into Cell Culture Technology. InTech, Rijeka, Croatia, pp 43–97.  DOI


 2016  

Bellin D, Delledonne M, Vandelle E (2016) Detection of peroxynitrite in plants exposed to bacterial infection. In Gupta KJ (ed) Plant Nitric Oxide Methods and Protocols. Methods in Molecular Biology 1424, Humana Press (Springer, NY, USA),  pp 191–200.

Boes A, Reimann A, Twyman RM, Fischer R, Schillberg S, Spiegel H (2016) A plant-based transient expression system for the rapid production of malaria vaccine candidates. In Thomas S (ed) Vaccine Design Methods and Protocols, Volume 2 Vaccines for Veterinary Diseases. Methods in Molecular Biology 1404, Humana Press (Springer, NY, USA),  pp 597619.

Mukherjee K, Baudach A (2016) Epigenetic control of polyphenism in aphids. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 89–99.

Peschen D, Schillberg S, Fischer R (2016) Antibody-mediated pathogen resistance in plants. In MacDonald J, Kolotilin I, Menassa R (eds) Recombinant Proteins from Plants. Methods in Molecular Biology 1385, Humana press (Springer, NY, USA), pp 273–291.

Schmidtberg H, Vilcinskas A (2016) The ontogenesis of the pea aphid Acyrthosiphon pisum. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 14–51.

Skaljac M (2016) Bacterial symbionts of aphids (Hemiptera: Aphididae). In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 100–125.

Vilcinskas A (2016) Aphid immunity. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 126–134.

Will T (2016) Aphid techniques. In Vilcinskas A (ed) Biology and Ecology of Aphids. CRC Press, Boca Raton, FL, USA, pp 255–270.


 2011-2015 

 

Cremer C, Hehmann-Titt G, Schiffer S, Melmer G, Carloni P, Barth S, Nachreiner T (2015) Engineered versions of granzyme B and angiogenin overcome intrinsic resistance to apoptosis mediated by human cytolytic fusion proteins. In: Verma RS, Bonavida B (eds) Resistance to Immunotoxins in Cancer Therapy (Resistance to Targeted Anti-Cancer Therapeutics Volume 6). Springer International, NY, USA, pp 185–219.

Fischer R, Buyel JF, Schillberg S, Twyman RM (2014) Molecular farming in plants: The long road to the market. In: Howard JA, Hood EE (eds) Commercial Plant-Produced Recombinant Protein Products. Biotechnology in Agriculture and Forestry, Volume 68. Springer Verlag, Berlin, pp 27–41.


Joop G, Vilcinskas A (2014) Evolutionary ecology of insect immunity. In: Hoffmann KH (ed) Insect Molecular Biology and Ecology. CRC Press, Boca Raton, FL, USA, pp 271–290.


Worden N, Girke T, Drakakaki G (2014) Endomembrane dissection using chemically induced bioactive clusters. In: Hicks GR, Robert S (eds) Plant Chemical Genomics. Methods in Molecular Biology 1056, Humana Press (Springer, NY, USA), pp 159–168.


Barth S, Gattenlöhner S, Tur MK (2013) Immunokinases. In: Schmidt SR (ed) Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. Blackwell-Wiley, NY, USA, pp 329–336.


Brandt A, Vilcinskas A (2013) The fruit fly Drosophila melanogaster as a model for aging research. In: Vilcinskas A (ed) Yellow Biotechnology I - Insect Biotechnology in Drug Discovery and Preclinical Research. Adv Biochem Eng Biotechnol, Volume 135. Springer, NY, USA, pp 63–77.


Fischer R, Ostafe R, Twyman RM (2013) Cellulases from insects. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 51–64.


Knorr E, Bingsohn L, Kanost MR, Vilcinskas A (2013) Tribolium castaneum as a model for high-throughput RNAi screening. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 163–178.

 

Mukherjee K, Raju R, Fischer R (2013) Galleria mellonella as a model host to study gut microbe homeostasis and brain infection by the human pathogen Listeria monocytogenes. In: Vilcinskas A (ed) Yellow Biotechnology I - Insect Biotechnology in Drug Discovery and Preclinical Research. Adv Biochem Eng Biotechnol, Volume 135. Springer, NY, pp 27–39.

 

Schott M, Wehrenfennig C, Gasch T (2013) Insect antenna-based biosensors for in situ detection of volatiles. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 101–122.

 

Will T, Vilcinskas A (2013) Aphid-proof plants: biotechnology-based approaches for aphid control. In: Vilcinskas A (ed) Yellow Biotechnology II - Insect Biotechnology in Plant Protection and Industry. Adv Biochem Eng Biotechnol, Volume 136. Springer, NY, USA, pp 179–203.


DalCorso G (2012) Heavy metal toxicity in plants. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 1–25.


Fasani E (2012) Plants that hyperaccumulate heavy metals. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 55–74.


Janzen C, Hoffmann K (2012) Optical measurements for the rational screening of protein crystallization conditions. In: Popp J, Tuchin VV, Chiou A, Heinemann SH (eds) Handbook of Biophotonics, Volume 3. John Wiley & Sons, NJ, USA, pp 257–290.


Manara A (2012) Plant responses to heavy metal toxicity. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 27–53.


Nesler A, Furini A (2012) Phytoremediation: the utilization of plants to reclaim polluted sites. In: Furini A (ed) Plants and Heavy Metals, Springer Briefs in Molecular Science, Springer, NY, USA, pp 75–86.

 

Farré G, Naqvi S, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RM, Capell T, Zhu C, Christou P (2011) Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway. In: Dunwell J (ed) Transgenic Plants: Protocols and Methods. Methods in Molecular Biology 847. Humana Press (Springer, NY, USA), pp 419–435.

 

Gottschalk U (2011) Overview of downstream processing in the biomanufacturing industry. In: Moo-Young M, Butler M, Webb C, Moreira A, Grodzinski B, Cui ZF, Agathos S (eds) Comprehensive Biotechnology, Second Edition. Elsevier/Pergamon, Oxford, UK, pp 669–682.

 

Tappe A, Gottschalk U (2011) Single-use downstream equipment. In: Eibl R, Eibl D (eds) Single-Use Technology in Biopharmaceutical Manufacture. John Wiley & Sons, NJ, USA, pp 91103.  


Tornielli GB, Zamboni A, Zenoni S, Delledonne M, Pezzotti M (2011) Transcriptomics and metabolomics for the analysis of grape berry development. In in Gerós H, Chaves MM, Delrot S (eds) The Biochemistry of the Grape Berry. Bentham Science Publishers, Sharjah, UAE, pp 218–240.

 

Twyman RM, Schillberg S, FIscher R (2011) The production of vaccines and therapeutic antibodies in plants. In: Ma S, Wang A (eds) Molecular Farming in Plants: Recent Advances and Future Prospects. Springer, NY, USA, pp 145–159.

 

Walter JK, Jin Z, Jornitz MW, Gottschalk U (2011) Membrane separations. In Janson J-C (ed) Protein Purification: Principles, High Resolution Methods, and Applications, Third Edition. Methods of Biochemical Analysis, Volume 54. John Wiley & Sons, NJ, USA, pp 279–317.

 


 2001-2010

Gottschalk U (2010) Disposables in downstream processing. In Eibl R, Eibl D (eds) Disposable Bioreactors. Adv Biochem Eng Biotechnol, Volume 115. Springer, Berlin/Heidelberg, pp 171–183.

 

Kohli A, Miro B, Twyman RM (2010) Transgene integration, expression and stability in plants: strategies for improvements. In Kole C, Michler CH, Abbott AG, Hall TC (eds) Biotech Plants, Volume 1: Concepts & Development. Springer-Verlag, Berlin, pp 201–238.


Schiermeyer A, Schillberg S (2010) Pharmaceuticals. In Kempken F, Jung C (eds) Genetic Modification of Plants. Biotechnology in Agriculture and Forestry, Volume 64. Springer NY, USA, pp 221–235.

 

Walter JK, Gottschalk U (2010) Concepts for disposables in biopharmaceutical manufacture. In Shire SJ, Gombotz W, Bechtold-Peters K, Andya J (eds) Current Trends in Monoclonal Antibody Development and Manufacturing. Biotechnology: Pharmaceutical Aspects, Volume IX. Springer, NY, USA, pp 87–99. 

 

Arunakumari A, Wang J (2009) Purification of human monoclonal antibodies: non-protein A strategies. In: Gottschalk U (ed) Process-scale Purification of Antibodies. Wiley-Blackwell, Oxford, UK, pp 103–123.


Cabanne C, Santarelli X (2009) Purification of antibodies other than IgG: the case of IgM and IgA. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 373–386.


Christou P, Capell T (2009) Transgenic crops and their applications for sustainable agriculture and food security. In Ferry N, Gatehouse AMR (eds) Environmental Impact of Genetically Modified Crops, CAB International, Wallingford, UK, pp 3–22.


Curling J (2009) The development of antibody purification technologies. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 25–52.


Etzel MR (2009) Charged ultrafiltration and microfiltration membranes in antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 325–347.


Farid SS (2009) Process economic drivers in industrial monoclonal antibody manufacture. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 239–261.

 

Fischer R, Schillberg S, Twyman RM (2009) Molecular farming of antibodies in plants. In: Kirakosyan A, Kaufman PB (eds) Recent Advances in Plant Biotechnology. Springer, NY, USA, pp 35–63.


Fontes N, van Reis R (2009) Advances in technology and process development for industrial-scale monoclonal antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 203–221.


Gagnon P (2009) Purification of monoclonal antibodies by mixed-mode chromatography. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 125–143.


Ghose S, Jin M, Liu J, Hickey J (2009) Integrated polishing steps for monoclonal antibody purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 145–167.


Glynn J (2009) Process-scale precipitation of impurities in mammalian cell culture broth. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 309–324.


Kelley B, Blank G, Lee A (2009) Downstream processing of monoclonal antibodies: current practices and future opportunities. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 1–23.


Li Y, Kahn DW, Galperina O, Blatter E, Luo R, Wu Y, Zhang G (2009) Development of a platform process for the purification of therapeutic monoclonal antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 187–201.


Müller-Späth T, Morbidelli M (2009) Continuous chromatography for the purification of monoclonal antibodies. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 223–238.


Nikolov ZL, Regan JY, Dickey LF, Woodard SL (2009) Purification of antibodies from transgenic plants. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 387–406.


Pujar N, Low D, O'Leary R (2009) Antibody purification: drivers of change. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 407–426.

 

Ramessar K, Naqvi S, Dashevskaya S, Peremarti A, Yuan D, Gomez-Galera D, Velez SMR, Farre G, Sabalza M, Miralpeix B, Twyman RM, Zhu C, Bassie L, Capell T, Christou P (2009) The contribution of plant biotechnology to food security in the 21st century. In: Amsel L, Hirsch L (eds)  Food Science and Security. Nova Science Publishers, NY, USA, pp 3–72.

 

Shukla AA, Kandula JR (2009) Harvest and recovery of monoclonal antibodies: cell removal and clarification. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 53–78.


Sinclair A (2009) Design and optimization of manufacturing. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 263–291.

 

Sparrow PAC, Twyman RM (2009) Biosafety and risk assessment of plant-made pharmaceuticals. In: Faye L, Gomord V (eds) Recombinant Pharmaceutical Proteins from Plants. Methods in Molecular Biology 483. Humana Press (Springer, NY, USA), pp 341–353.


Spitali M (2009) Downstream processing of monoclonal antibody fragments. In: Gottschalk U (ed)Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 349–372.


Thömmes J, Gottschalk U (2009) Alternatives to packed-bed chromatography for antibody extraction and purification. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 293–308.

 

Twyman RM (2009) Wnt pathway and neural patterning. In: Lemke G (ed) Developmental Neurobiology. Elsevier Press, Amsterdam, Netherlands, pp 39–44.

 

Twyman RM (2009) Transcriptional silencing. In: Lemke G (ed) Developmental Neurobiology. Elsevier Press, Amsterdam, Netherlands, pp 178–183.


Vunnum S, Vedantham G, Hubbard B (2009) Protein A-based affinity chromatography. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 79–102.


Zenoni S, Zamboni A, Porceddu A, Pezzotti M (2009) The role of expansins A in petunia development. In: Greats T, Strommer J (eds) Petunia. Springer, NY, USA, pp 247–267.


Zhou JX (2009) Orthogonal virus clearance applications in monoclonal antibody production. In: Gottschalk U (ed) Process Scale Purification of Antibodies. John Wiley & Sons, Inc., Hoboken, NJ, pp 169–186.

 

Fischer R, Twyman RM, Hellwig S, Drossard J, Schillberg S (2007) Facing the future with pharmaceuticals from plants. In: Xu Z, Li J, Xue Y, Yang W (eds) Biotechnology and Sustainable Agriculture 2006 and Beyond. Proceedings of the 11th IAPTC&B Congress, August 13-18, 2006 Beijing, China. Springer, NY, USA, pp 13–32.

 

Gottschalk U (2007) Downstream procesing. In: Jornitz MJ, Meltzer TH (eds) Filtration and Purification in the Biopharmaceutical Industry, Second Edition. Drugs and the Pharmaceutical Sciences, Volume 174. Informa Healthcare NY, USA/London, UK, pp 459–494.

 

Gottschalk U (2007) Downstream processing: removing economic and technical bottlenecks. In: Langer ES (ed) Advances in Large-Scale Biopharmaceutical Manufacturing and Scale-Up Production, Second Edition. BioPlan Associates Inc., Rockville MD/ASM Press, Washington DC, USA, pp 913–948.

 

Twyman RM, Schillberg S, Fischer R (2007) Molecular farming of antibodies in plants. In: Ranalli P (ed) Improvements of Crop Plants for Industrial End Uses.  Springer-Verlag,  NY, USA, pp 435-469.

 

Twyman RM, Schillberg S, Fischer R (2006) Production of therapeutic antibodies and heterologous recombinant proteins in plant systems. In: Kayser O, Quax W (eds) Medicinal Plant Biotechnology. Wiley-VCH, Weinheim, Germany, pp 319–344.


Zimmermann S, Emans N, Fischer R, Schillberg S (2006) Plantibody-based disease resistance in plants. In: Tuzun S, Bent E (eds) Multigenic and Induced Systemic Resistance in Plants. Springer, NY, USA, pp 456–476.

 

Fischer R, Twyman RM, Drossard J, Hellwig S, Schillberg S (2005) Plant cells. In: Gellissen G (ed) Production of Recombinant Proteins: Novel Microbial and Eukaryotic Expression Systems. Wiley-VCH, Weinheim, Germany, pp 253–272.

 

Schillberg S, Twyman RM, Fischer R (2005) Biopharmaceutical production in cultured plant cells. In: Knablein J (ed) Modern Biopharmaceuticals - Design, Development and Optimization. Wiley-VCH,  Weinheim,  Germany,  pp 949–966.

 

Ammann K (2004) The role of science and discourse in the application of the precautionary approach. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 291–302.


Bischoff F (2004) A top-down view of molecular farming from the pharmaceutical industry: requirements and expectations. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 267–290.


Brandle J (2004) The field evaluation of transgenic crops engineered to produce recombinant proteins. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 69–76.


Chargelegue D, Drake PMW, Obregon P, Ma JKC (2004) Production of secretory IgA in transgenic plants. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 159–169.


Christou P, Stoger E, Twyman RM (2004) Monocot expression systems for molecular farming. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 55–67.
 
Commandeur U, Twyman RM (2004) Biosafety aspects of molecular farming in plants. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 251–266.

 

Daniell H, Carmona-Sanchez O, Burns BE (2004) Chloroplast derived antibodies, biopharmaceuticals and edible vaccines. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 113–133.


D'Aoust MA, Busse U, Martel M, Lerouge P, Levesque D, Vézina LP (2004) Perennial plants as a production system for pharmaceuticals. In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, NJ, USA, pp 759–767.


D'Aoust MA, Lerouge P, Busse U, Bilodeau P, Trépanier S, Gomord V, Faye L, Lou Vézina LP (2004) Efficient and reliable production of pharmaceuticals in alfalfa. In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, NJ, USA, pp 1–12.


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