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Description
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Twyman
Research
Management Ltd
Description
Specialist consultants in scientific project development, management and presentation

 Chapters in anthologies 


Hundleby PAC, Sack M, Twyman RM (2018) Biosafety, risk assessment and regulation of molecular farming. 
In: Kermode A, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. John Wiley & Sons, Inc., Hoboken, NJ, pp 329–351.  DOI

Spiegel H, Stöger E, Twyman RM, Buyel JF (2018) Current status and perspectives of the molecular farming landscape. 
In: Kermode A, Jiang L (eds) Molecular Pharming: Applications, Challenges and Emerging Areas. John Wiley & Sons, Inc., Hoboken, NJ, pp 3–23.  DOI

Buyel JF, Twyman RM, Fischer R (2017) Very-large-scale production of monoclonal antibodies in plants. 
In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 655–672.  DOI

Schillberg S, Raven N, Fischer R, Twyman RMSchiermeyer A (2017) Contained molecular farming using plant cell and tissue cultures. 
In: Yoshida T (ed) Applied Bioengineering: Innovations and Future Directions. Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 261–281.  DOI  

Thömmes J, Twyman RM, Gottschalk U (2017) Alternatives to packed-bed chromatography for antibody extraction and purification. 
In: Gottschalk U (ed) Process Scale Purification of Antibodies (second edition). John Wiley & Sons, Inc., Hoboken, NJ, pp 215–232.  DOI

Farré G, Naqvi S, Sanahuja G, Zorrilla-López U, Sanahuja G, Berman J, Sandman G, Ros G, Lopez-Nicolas R, Twyman RM, Christou P, Capell T, Zhu C (2013) Transgenic multivitamin biofortified corn: science, regulation, and politics. 

In: Preedy VR, Srirajaskanthan R, Patel VB (eds) Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1. Nutrition and Health. Springer, New York, NY, pp 335–347.  DOI  


Twyman RM, Schillberg S, Fischer R (2012) The production of vaccines and therapeutic antibodies in plants. 

In: Wang A, Ma S (eds) Molecular Farming in Plants: Recent Advances and Future Prospects. Springer, Dordrecht, Netherlands, pp 145159.  DOI  


Kohli A, Miro B, Twyman RM (2010) Transgene integration, expression and stability in plants: strategies for improvements. 

In: Kole C, Michler CH, Abbott AG, Hall TC (eds) Transgenic Crop Plants: Principles and Development. Springer, Berlin, Heidelberg, Germany, pp 201238.  DOI  

 

Fischer R, Schillberg S, Twyman RM (2009) Molecular farming of antibodies in plants. 

In: Kirakosyan A, Kaufman PB (eds) Recent Advances in Plant Biotechnology. Springer US, Boston, MA, pp 3563.  DOI  

 

Fischer R, Twyman RM, Hellwig S, Drossard J, Schillberg S (2007) Facing the future with pharmaceuticals from plants. 

In: Xu Z, Li J, Xue Y, Yang W (eds) Biotechnology and Sustainable Agriculture 2006 and Beyond. Springer, Dordrecht, Netherlands, pp 1332.  DOI  

 

Twyman RM, Schillberg S, Fischer R (2007) Molecular farming of antibodies in plants. 

In: Ranalli P (ed) Improvements of Crop Plants for Industrial End Uses. Springer, Dordrecht, Netherlands, pp 435–469.  DOI  

 
Twyman RM, Schillberg S, Fischer R (2006) Production of therapeutic antibodies in plants. 

In: Kayser O, Quax W (eds) Medicinal Plant Biotechnology: From Basic Research to Industrial Applications. Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 319344.  DOI  

 

Fischer R, Twyman RM, Drossard J, Hellwig S, Schillberg S (2005) Plant cells. 

In: Gellissen G (ed) Production of Recombinant Proteins: Novel Microbial and Eukaryotic Expression SystemsWiley-VCH Verlag GmbH, Weinheim, Germanypp 253272.  DOI


Schillberg S, Twyman RM, Fischer R (2005) Biopharmaceutical production in cultured plant cells. 

In: Knäblein J (ed) Modern Biopharmaceuticals: Design, Development and Optimization. Wiley-VCH Verlag GmbH, Weinheim, Germany, pp 949–966.  DOI  

 

Christou P, Stoger E, Twyman RM (2004) Monocot systems for molecular farming. 

In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, Inc., Hoboken, NJ, pp 5567.  DOI  

 

Commandeur U, Twyman RM (2004) Biosafety aspects of molecular farming in plants. 

In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, Inc., Hoboken, NJ, pp 251266.  DOI  

 

Schillberg S, Twyman RM (2004) Emerging production systems for antibodies in plants. 

In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, Inc., Hoboken, NJpp 801–810.  DOI

 

Stoger E, Marcel S, Twyman RM (2004) Crop plants for molecular farming. 

In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, Inc., Hoboken, NJ, pp 747–758.  DOI

 

Twyman RM, Christou P (2004) Plant transformation technology - particle bombardment. 

In: Christou P, Klee H (eds) Handbook of Plant Biotechnology. John Wiley & Sons, Inc., Hoboken, NJ, pp 263289.  DOI

 

Twyman RM (2004) Host plants, systems and expression strategies for molecular farming. 

In: Fischer R, Schillberg S (eds) Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins. John Wiley & Sons, Inc., Hoboken, NJ, pp 191216.  DOI  

 

Fischer R, Emans NJ, Twyman RM, Schillberg S (2003) Molecular farming of industrial proteins in plants. 

In: Fingerman M, Nagabhushanam R (eds) Recent Advances in Marine Biotechnology, Volume 9. Biomaterials and Bioprocessing. CRC Press, Boca Raton, FL, pp 279313.

 

Twyman RM, Christou P, Stoger E (2002) Genetic transformation of plants and their cells.  

In: Oksman-Caldentey KM, Barz W (eds) Plant Biotechnology and Transgenic Plants. Marcel Dekker, New York, NY, pp 111141.  DOI  




 Chapters in book series 

Fischer R, Holland T, Sack M, Schillberg S, Stoger E, Twyman RM, Buyel JF (2018) Glyco-engineering of plant-based expression systems. 
In: Rapp E, Reichl U (eds) Advances in Glycobiotechnology. Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg (online first).  DOI

Boes A, Reimann A, 
Twyman RM, Fischer R, Schillberg S, Spiegel H (2016) A plant-based transient expression system for the rapid production of malaria vaccine candidates. 
In: Thomas S (ed) Vaccine DesignMethods and Protocols Volume 2, Vaccines for Veterinary Diseases. Methods in Molecular Biology 1404. Humana Press, New York, NY, pp 597–619.  DOI

Fischer R, Buyel JF, Schillberg S, Twyman RM (2014) Molecular farming in plants: The long road to the market. 

In: Howard JA, Hood EE (eds) Commercial Plant-Produced Recombinant Protein Products: Case Studies. Biotechnology in Agriculture and Forestry 68. Springer, Berlin, Heidelberg, Germany, pp 27–41.  DOI


Fischer R, Ostafe R, Twyman RM (2013) Cellulases from insects. 

In: Vilcinskas A (ed) Yellow Biotechnology II: Insect Biotechnology in Plant Protection and Industry. Advances in Biochemical Engineering/Biotechnology 136. Springer, Berlin Heidelberg, Germany, pp 51–64.  DOI  


Farré G, Naqvi S, Sanahuja G, Sanahuja G, Bai C, Zorrilla-López U, Rivera SM, Canela R, Sandman G, Twyman RMCapell T, Zhu C, Christou P (2012) Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway. 

In: Dunwell JM, Wetten AC (eds) Transgenic Plants: Methods and Protocols. Methods in Molecular Biology 847. Humana Press, New York, NY, pp 419–435.  DOI  


Sparrow PAC, Twyman RM (2009) Biosafety and risk assessment of plant-made pharmaceuticals. 

In: Faye L, Gomord V (eds) Recombinant Proteins from Plants: Methods and Protocols. Methods in Molecular Biology 483. Humana Press, New York, NYpp 341–353.  DOI  


Stoger E, Schillberg S, Twyman RM, Fischer R, Christou P (2004) Antibody production in transgenic plants. 

In: Lo BKC (ed) Antibody Engineering: Methods and ProtocolsMethods in Molecular Biology 248. Humana Press, Totowa, NJpp 301–318.  DOI  

 

Twyman RM, Stoger E, Kohli A, Capell T, Christou P (2002) Selectable and screenable markers for rice transformation. 

In: Jackson JF, Linskens HF (eds) Testing for Genetic Manipulation in Plants. Molecular Methods of Plant Analysis 22. Springer, Berlin, Heidelberg, Germany, pp 1–17.  DOI  

 

Twyman RM, Stoger E, Kohli A, Christou P (2002) Foreign DNA: integration and expression in transgenic plants. 

In: Setlow JK (ed) Genetic Engineering. Genetic Engineering: Principles and Methods 24. Springer US, Boston, MA, pp 107–136.  DOI  




 Chapters in textbooks 

Twyman RM (2009) Wnt pathway and neural patterning. 

In: Lemke G (ed) Developmental Neurobiology. Academic Press, London, UK, pp 39–44.
 
Twyman RM (2009) Transcriptional silencing. 

In: Lemke G (ed) Developmental Neurobiology. Academic Press, London, UK, pp 178–183.


Strachan T, Twyman RM [uncredited] (2003) Cells and development. 

In: Strachan T, Reid AP, Human Molecular Genetics 3. Garland Science, New York, NY, pp 59100.

 

Twyman RM [uncredited] (2003) Beyond the genome project: an introduction to functional genomics. 

In: Strachan T, Reid AP, Human Molecular Genetics 3. Garland Science, New York, NY, pp 539574.

 

Twyman RM [uncredited] (2003) Genetic modification of cells and animals. 

In: Strachan T, Reid AP, Human Molecular Genetics 3. Garland Science, New York, NY, pp 575608.


Sgouros JG, Twyman RM (2002) Gene finding. 

In: Orengo C, Jones DT, Thornton JM (eds) Bioinformatics: Genes, Proteins & Computers. BIOS Scientific Publishers, Oxford, UK, pp 18–28.

 

Twyman RM (2002) Building the body the molecular basis of development. 

In: Sweeney S, Hodder D (eds) The Body (Darwin College Lectures). Cambridge University Press, Cambridge, UK, pp 12–24.  


Weir MP, Blackstock WP, Twyman RM (2002) Proteomics. 

In: Orengo C, Jones DT, Thornton JM (eds) Bioinformatics: Genes, Proteins & Computers. BIOS Scientific Publishers, Oxford, UK, pp 245–258.

Richard Twyman's Book Chapters

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